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What is the orexigenic effect ?

Dorsomedial hypothalamic nucleus

Prolactin-releasing peptide

Cocaine and amphetamine regulated transcript

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The orexigenic effect refers to the stimulation of appetite or food intake. It is the ability of certain substances or hormones to increase the desire to eat and promote feeding behavior. Orexigenic peptides, such as orexin A and cocaine- and amphetamine-regulated transcript (CART) peptide, have been found to have an orexigenic effect . These peptides can increase food intake when injected into specific areas of the hypothalamus, such as the arcuate nucleus (ARC) . The orexigenic effect of these peptides may be mediated by the release of other orexigenic neuropeptides, such as neuropeptide Y (NPY) . The orexigenic effect of these peptides may also be influenced by other factors, such as the neuroendocrine milieu and the presence of certain receptors, such as opioid mu-receptors . Overall, the orexigenic effect plays a crucial role in regulating appetite and food intake.

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Journal Article•DOI Exogenous prolactin-releasing peptide's orexigenic effect is associated with hypothalamic neuropeptide Y in chicks. Guoqing Wang, Tetsuya Tachibana, Elizabeth R. Gilbert, Mark A. Cline - Show less +3 more 01 Dec 2015-Neuropeptides 11 Citations	The orexigenic effect refers to the stimulation of food intake or hunger perception.
Journal Article•DOI The orexigenic effect of GnIH is mediated by central opioid receptors in chicks. Tetsuya Tachibana, Naoto Masuda, Kazuyoshi Tsutsui, Kazuyoshi Ukena, Hiroshi Ueda - Show less +4 more 01 May 2008-Comparative Biochemistry and Physiology A-molecular & Integrative Physiology 48 Citations	The orexigenic effect refers to the stimulation of feeding behavior and increased food intake.
Journal Article•DOI Orexigenic and cytoprotective effects of a novel adenosine-enriched peptide nucleic acid compound: Implications for clinical application J. T. D’Olimpio, S. Elliston, M. Dediego, R. Sodum - Show less +3 more 20 Jun 2007-Journal of Clinical Oncology 2 Citations	The orexigenic effect refers to the ability of a substance to stimulate appetite and increase food intake.
Open access•Journal Article•DOI The Orexigenic Effect of Orexin-A Revisited: Dependence of an Intact Growth Hormone Axis Mayte Alvarez-Crespo, Noelia Martínez-Sánchez, Francisco Ruiz-Pino, Montserrat Garcia-Lavandeira, Clara V. Alvarez, Manuel Tena-Sempere, Rubén Nogueiras, Carlos Dieguez, Miguel López - Show less +8 more 16 Jul 2013-Endocrinology 12 Citations	The orexigenic effect refers to the stimulation of appetite and increase in food intake.
Open access•Journal Article•DOI Orexigenic effect of cocaine‐ and amphetamine‐regulated transcript (CART) after injection into hypothalamic nuclei in streptozotocin‐diabetic rats Jun Hou, De-Zhi Zheng, Ji-Yin Zhou, Shi-Wen Zhou - Show less +3 more 01 Oct 2010-Clinical and Experimental Pharmacology and Physiology 23 Citations	The orexigenic effect refers to the stimulation of appetite or increase in food intake.

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