What is the relationship between vero cell's metabolism and Flavivirus infection ?
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Vero cells' metabolism plays a crucial role in Flavivirus infections. Studies have shown that Flavivirus infections, such as West Nile virus (WNV), Usutu virus, dengue virus, and Zika virus, significantly impact cellular lipid metabolism, glycolysis, tricarboxylic acid cycle, and fatty acid oxidation pathways in Vero cells . The alteration of sphingolipid metabolism, particularly the inhibition of ceramide desaturase, promotes the accumulation of dihydrosphingomyelin, affecting membrane properties and inhibiting viral multiplication . Additionally, inhibiting fatty acid biosynthesis creates a metabolically refractory environment, forcing the virus to rely on alternate metabolic pathways for survival, ultimately disrupting viral replication and membrane architecture critical for the viral life cycle in Vero cells . This interplay between Vero cell metabolism and Flavivirus infections highlights potential targets for antiviral strategies.
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| Papers (5) | Insight |
|---|---|
| Inhibition of fatty acid biosynthesis in Vero cells creates a metabolically refractory environment, impacting Flavivirus replication by altering cellular metabolic landscapes and membrane architecture critical for viral life cycle. | |
| Polyphenols altered sphingolipid metabolism in Vero cells, inhibiting ceramide desaturase and increasing dihydrosphingomyelin levels, providing a novel antiviral strategy against Flavivirus infections like West Nile Virus. | |
| Mayaro virus infection alters Vero cell metabolism, affecting glycolysis, TCA cycle, pentose phosphate pathway, and fatty acid oxidation, reflecting cytopathological changes induced by the virus. | |
| Vero cells show lower initial Flavivirus production and slower plaque development compared to Huh7.5.1-8 cells, indicating potentially different metabolic responses to Flavivirus infection. | |
| Not addressed in the paper. |
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