Sudip Khadka

TL;DR: Mechanistic insight into DENV membrane remodeling is provided and the potential for the development of therapeutics that inhibit DENV replication by targeting the fatty acid biosynthetic pathway is highlighted.

TL;DR: Dengue virus (DENV), an emerging mosquito-transmitted pathogen capable of causing severe disease in humans, interacts with host cell factors to create a more favorable environment for replication and provides additional support for the hypothesis that viruses preferentially target cellular proteins that occupy central position in the human protein interaction network.

TL;DR: ARB inhibits six different isolates of Zika virus (ZIKV), including African and Asian lineage viruses in multiple cell lines and primary human vaginal and cervical epithelial cells and protects against ZIKV-induced cytopathic effects.

TL;DR: An amino‐tetrahydrocarbazole compound SW835 inhibits Ebola virus, vesicular stomatitis virus and Zika virus replication and induces interferon stimulated genes (ISGs), which subverts EBOV immune evasion functions.

TL;DR: A large-scale yeast two-hybrid screen to identify protein-protein interactions between HCV genotype 2a (strain JFH1) and cellular factors found that five of the ten shared targets tested were required for replication of both HCV and dengue virus.