What is the role of IL-1b in regulating metabolism and energy balance?
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IL-1β plays a crucial role in regulating metabolism and energy balance by influencing various physiological processes. It has been found that IL-1β contributes to postprandial insulin secretion, adjusts glucoregulation in the brain, and enhances glucose uptake into macrophages. Additionally, IL-1β can stimulate brain metabolism, affect butyrate oxidation in colorectal cancer cells, and is required for maintaining steady-state glucose homeostasis. These findings highlight the multifaceted impact of IL-1β on glucose metabolism, insulin secretion, and energy provision to neural cells, underscoring its significance in maintaining metabolic homeostasis and energy balance.
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| Papers (5) | Insight |
|---|---|
| IL-1β plays a dual role in metabolism; it is associated with inflammation and obesity but also aids in maintaining glucose homeostasis by enhancing postprandial insulin secretion. | |
20 Citations | IL-1β diminishes butyrate oxidation in colorectal cancer cells, suppressing NADH levels and mitochondrial respiration. It shifts cancerous colonocytes away from utilizing and oxidizing butyrate, impacting energy metabolism. |
| IL-1β, secreted by macrophages postprandially, stimulates insulin secretion, promoting glucose uptake. IL-1β and insulin synergistically regulate glucose disposal and inflammation, playing a crucial role in metabolism and immunity. | |
21 Citations | IL-1β adjusts glucoregulation, stimulates brain metabolism, and provides fuel to neural cells in an autocrine/paracrine manner, supporting synaptic plasticity, learning, and memory. |
3 Citations | IL-1β plays a crucial role in glucose homeostasis by promoting postprandial insulin secretion, regulating glucose disposal, and alerting the immune system to prevent microbial dissemination from food. |
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