T
Thierry Berney
Researcher at Geneva College
Publications - 393
Citations - 16864
Thierry Berney is an academic researcher from Geneva College. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 62, co-authored 369 publications receiving 15159 citations. Previous affiliations of Thierry Berney include Catholic University of Leuven & University of Miami.
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Journal ArticleDOI
International Trial of the Edmonton Protocol for Islet Transplantation
A. M. James Shapiro,Camillo Ricordi,Bernhard J. Hering,Hugh Auchincloss,Robert Lindblad,R. Paul Robertson,Antonio Secchi,Mathias D. Brendel,Thierry Berney,Daniel C. Brennan,Enrico Cagliero,Rodolfo Alejandro,Edmond A. Ryan,Barbara S. Dimercurio,Philippe Morel,Kenneth S. Polonsky,Jo Anna Reems,Reinhard G. Bretzel,Federico Bertuzzi,Tatiana Froud,Raja Kandaswamy,David E.R. Sutherland,George S. Eisenbarth,Miriam Segal,Jutta K. Preiksaitis,Gregory S. Korbutt,Franca B. Barton,Lisa Viviano,Vicki Seyfert-Margolis,Jeffrey A. Bluestone,Jonathan R. T. Lakey +30 more
TL;DR: Islet transplantation with the use of the Edmonton protocol can successfully restore long-term endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus and unstable control, but insulin independence is usually not sustainable.
Journal ArticleDOI
Improvement in outcomes of clinical islet transplantation: 1999-2010.
Franca B. Barton,Michael R. Rickels,Rodolfo Alejandro,Bernhard J. Hering,Stephen Wease,Bashoo Naziruddin,Jose Oberholzer,Jon S. Odorico,Marc R. Garfinkel,Marlon F. Levy,François Pattou,Thierry Berney,Antonio Secchi,Shari Messinger,Peter A. Senior,Paola Maffi,Andrew M. Posselt,Peter G. Stock,Dixon B. Kaufman,Xunrong Luo,Fouad Kandeel,Enrico Cagliero,Nicole A. Turgeon,Piotr Witkowski,Ali Naji,Philip J. O'Connell,Carla J. Greenbaum,Yogish C. Kudva,Kenneth L. Brayman,Meredith J. Aull,Christian P. Larsen,Thomas W.H. Kay,Luis A. Fernandez,Marie-Christine Vantyghem,Melena D. Bellin,A. M. James Shapiro +35 more
TL;DR: The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007–2010 compared with those in 1999–2006, with fewer islet infusions and adverse events per recipient.
Journal ArticleDOI
A map of open chromatin in human pancreatic islets
Kyle J. Gaulton,Takao Nammo,Lorenzo Pasquali,Jeremy M. Simon,Paul G. Giresi,Marie P. Fogarty,Tami M. Panhuis,Piotr A. Mieczkowski,Antonio Secchi,Domenico Bosco,Thierry Berney,Eduard Montanya,Karen L. Mohlke,Jason D. Lieb,Jorge Ferrer +14 more
TL;DR: It is found that human islet samples heterozygous for rs7903146 showed allelic imbalance in islet FAIRE signals and that the variant alters enhancer activity, indicating that genetic variation at this locus acts in cis with local chromatin and regulatory changes.
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Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants
Lorenzo Pasquali,Kyle J. Gaulton,Kyle J. Gaulton,Kyle J. Gaulton,Santiago A. Rodríguez-Seguí,Loris Mularoni,Irene Miguel-Escalada,Ildem Akerman,Juan J. Tena,Ignasi Moran,Carlos Gómez-Marín,Martijn van de Bunt,Martijn van de Bunt,Martijn van de Bunt,Joan Ponsa-Cobas,Natalia Castro,Takao Nammo,Inês Cebola,Javier García-Hurtado,Miguel Angel Maestro,François Pattou,Lorenzo Piemonti,Thierry Berney,Anna L. Gloyn,Anna L. Gloyn,Philippe Ravassard,José Luis Gómez Skarmeta,Ferenc Müller,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Jorge Ferrer +31 more
TL;DR: This work mapped and examined the function of human islet cis-regulatory networks and identifies genomic sequences that are targeted by islet transcription factors to drive islet-specific gene activity and shows that most such sequences reside in clusters of enhancers that form physical three-dimensional chromatin domains.
Journal ArticleDOI
Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
Ignasi Moran,Ildem Akerman,Martijn van de Bunt,Martijn van de Bunt,Ruiyu Xie,Marion Benazra,Takao Nammo,Luis Arnes,Nikolina Nakic,Javier García-Hurtado,Santiago A. Rodríguez-Seguí,Lorenzo Pasquali,Claire Sauty-Colace,Anthony Beucher,Raphael Scharfmann,Joris van Arensbergen,Paul Johnson,Paul Johnson,Andrew Berry,Clarence Lee,Timothy T. Harkins,Valery Gmyr,François Pattou,Julie Kerr-Conte,Lorenzo Piemonti,Thierry Berney,Neil A. Hanley,Anna L. Gloyn,Lori Sussel,Linda Langman,Kenneth L. Brayman,Maike Sander,Mark I. McCarthy,Mark I. McCarthy,Philippe Ravassard,Jorge Ferrer,Jorge Ferrer +36 more
TL;DR: A comprehensive strand-specific transcriptome map of human pancreatic islets and β cells is reported, and a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology are revealed.