What is the role of Rap1 signaling pathway in immune cells?
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The Rap1 signaling pathway plays a crucial role in immune cells by regulating integrin activation, actin remodeling, and cytoskeletal reorganization. In T cells, Rap1 deficiency can lead to spontaneous colitis due to impaired induction of regulatory T cells and enhanced Th17 responses. Additionally, Rap1 is involved in the adhesive interactions of hematopoietic stem cells in the bone marrow, affecting their growth, survival, and differentiation. Furthermore, the inactivation of Rap1 is essential for proper lymphocyte trafficking, as demonstrated by the role of Rap1-inactivating proteins in regulating T cell adhesion and migration. Overall, the Rap1 signaling pathway is integral for immune cell function, including integrin activation, immune cell differentiation, and lymphocyte trafficking.
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| Papers (5) | Insight |
|---|---|
| Rap1-GAPs Rasa3 and Sipa1 regulate Rap1 in T cells, crucial for lymphocyte trafficking. Rap1 inactivation allows T cell transit through lymph nodes but prevents lung egress, highlighting its importance in immune cell migration. | |
| Rap1 GTPases play a crucial role in growth, differentiation, and migration of myeloid cells, impacting immune cell function through regulation of adhesion and signaling pathways. | |
| Rap1 signaling pathway in immune cells facilitates Treg cell differentiation, prevents colitogenic Th17 cell expansion, and enhances distal TCR signaling, crucial for immune homeostasis and colitis prevention. | |
3 Citations | The Rap1 signaling pathway, particularly through RIAM, plays a crucial role in inside-out integrin activation, actin remodeling, cytoskeletal reorganization, and phagocytosis in immune cells. |
3 Citations | The Rap1 signaling pathway, particularly through its interaction with RIAM, plays a crucial role in inside-out integrin activation, signal integration, actin remodeling, and cytoskeletal reorganization in immune cells. |
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