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Noriyuki Fujikado
Researcher at Harvard University
Publications - 19
Citations - 3159
Noriyuki Fujikado is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Gene expression. The author has an hindex of 11, co-authored 17 publications receiving 2845 citations. Previous affiliations of Noriyuki Fujikado include University of Tokyo.
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Journal ArticleDOI
Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses
Harumichi Ishigame,Shigeru Kakuta,Takeshi Nagai,Motohiko Kadoki,Aya Nambu,Yutaka Komiyama,Noriyuki Fujikado,Yuko Tanahashi,Aoi Akitsu,Hayato Kotaki,Katsuko Sudo,Susumu Nakae,Chihiro Sasakawa,Yoichiro Iwakura +13 more
TL;DR: It is demonstrated with Il17a(-/-), Il17f(-/-) mice that IL-17F played only marginal roles, if at all, in the development of delayed-type and contact hypersensitivities, autoimmune encephalomyelitis, collagen-induced arthritis, and arthritis in Il1rn(-/-).
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Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans
Shinobu Saijo,Satoshi Ikeda,Keiko Yamabe,Shigeru Kakuta,Harumichi Ishigame,Aoi Akitsu,Noriyuki Fujikado,Toshimasa Kusaka,Sachiko Kubo,Soo Hyun Chung,Ryohei Komatsu,Noriko Miura,Yoshiyuki Adachi,Naohito Ohno,Kazutoshi Shibuya,Natsuo Yamamoto,Kazuyoshi Kawakami,Sho Yamasaki,Takashi Saito,Shizuo Akira,Yoichiro Iwakura +20 more
TL;DR: This study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation and generates Clec4n(-/-) mice that had virtually no fungal alpha-mannan-induced cytokine production.
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Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.
Shinobu Saijo,Noriyuki Fujikado,Takahisa Furuta,Soo Hyun Chung,Hayato Kotaki,Keisuke Seki,Katsuko Sudo,Shizuo Akira,Yoshiyuki Adachi,Naohito Ohno,Takeshi Kinjo,Kiwamu Nakamura,Kazuyoshi Kawakami,Yoichiro Iwakura +13 more
TL;DR: Protective immunity to pneumocystis, but not to candida, required dectin-1 for the production of antifungal reactive oxygen species, and wild-type and dectIn-1-knockout mice were equally susceptible to candidA infection.
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Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
Siyoung Yang,Siyoung Yang,Noriyuki Fujikado,Dmitriy Kolodin,Christophe Benoist,Christophe Benoist,Diane Mathis,Diane Mathis +7 more
TL;DR: It is reported that Aire promotes the perinatal generation of a distinct compartment of Foxp3+CD4+ regulatory T (Treg) cells, which stably persists in adult mice, which expands the notion of a developmentally layered immune system.
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Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells.
Noriyuki Fujikado,Shinobu Saijo,Tomo Yonezawa,Kazusuke Shimamori,Akina Ishii,Sho Sugai,Hayato Kotaki,Hayato Kotaki,Katsuko Sudo,Katsuko Sudo,Masato Nose,Yoichiro Iwakura +11 more
TL;DR: It is found that aged Dcir−/− mice spontaneously develop sialadenitis and enthesitis associated with elevated serum autoantibodies, which indicates that D cir is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system.