What is the role of SNC in regulating the immune system in the periphery?
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The peripheral nervous system plays a crucial role in regulating the immune system in the periphery. Neural signals transmitted through sympathetic innervations to lymphoid organs allow for neural-immune interactions . These neural signals are transduced to immune cells via noradrenergic receptors, which regulate immune cell functions in a receptor subtype-specific manner . Conversely, immune effectors such as cytokines and chemokines released by immune cells can interact with cells in the central nervous system, such as microglia and astrocytes, to regulate neural functions . Additionally, the neuroendocrine network, involving the hypothalamus and pituitary gland, interacts with immune cells through hormone release . This bidirectional communication between the nervous and immune systems forms a robust neuroendocrine immune network . The role of the peripheral immune system in regulating central nervous system homeostasis and disease, particularly in neurodegenerative diseases, has also been highlighted . Neurons in the central nervous system control local immune cells through contact-dependent and -independent mechanisms, inhibiting inflammation and activating infiltrated T-cells .
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| Papers (4) | Insight |
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46 Citations | The provided paper does not specifically mention the role of SNC (soluble immune mediators) in regulating the immune system in the periphery. |
| The provided paper does not specifically mention the role of the SNC (central nervous system) in regulating the immune system in the periphery. | |
| The paper does not mention the role of SNC in regulating the immune system in the periphery. The paper focuses on the expression of neuro-receptors on immune cells and their role in immune cell functionality and communication with the microenvironment. | |
| The paper does not specifically mention the role of the SNC (Sympathetic Nervous System) in regulating the immune system in the periphery. The paper focuses on the role of neural-immune dysregulation in the periphery in the development of age-associated immune dysfunctions. |
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