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What is the significance of synaptic signaling in cancer progression?

Long-term potentiation

Tropomyosin receptor kinase B

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Synaptic signaling plays a crucial role in cancer progression by influencing tumor growth and metastasis. Neuronal activity regulates cancer development through mechanisms like neuron-to-tumor synapses, where malignant cells integrate into neural circuitry, promoting proliferation and invasion. In gliomas, synaptic proteins like neuroligin-3 and AMPA receptors drive tumor progression by enhancing synaptic plasticity and strength. Tumors exhibit higher electrical activity, with intratumoral nerves forming functional connections and promoting cancer progression through neuropeptides like Substance P. Understanding how tumors co-opt synaptic signaling pathways provides insights into novel therapeutic strategies targeting these mechanisms to impede cancer growth and spread. This highlights the importance of considering the nervous system's role in cancer biology for developing effective treatment approaches.

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Open access•Journal Article•DOI Functional neuronal circuits promote disease progression in cancer Anthony C. Restaino, A. Walz, Samuel J. Vermeer, Jeffrey Barr, Robin R. Fettig, Daniel W. Vermeer, Hunter D. Reavis, Caitlin S. Williamson, Christopher T. Lucido, Tuany Eichwald, Dalia K. Omran, Euihye Jung, Lauren Schwartz, Maria C. Bell, Desirae M Muirhead, Jody E. Hooper, William C. Spanos, Ronny Drapkin, Sébastien Talbot, Paola D. Vermeer - Show less +19 more 01 May 2023-Science Advances 1 Citations	Synaptic signaling within tumors, involving neuropeptides like Substance P, promotes cancer progression by enhancing cellular proliferation and migration through the engagement of the NK1R receptor.
Open access•Journal Article•DOI The dark side of synaptic proteins in tumours Jing Li, Yalan Xu, Hai Zhu, Yin Wang, Peifeng Li, Hongzhi Wang - Show less +5 more 27 May 2022-Cell Biology and Immunology of Leukocyte Function 4 Citations	Synaptic signaling plays a crucial role in cancer progression by involving synaptic proteins like neuroligin-3, AMPAR, NMDAR, and DLGAP1, influencing tumor cell proliferation and progression in the microenvironment.
Journal Article•DOI Neural Signaling in Cancer. Michael B. Keough, Michelle Monje - Show less +1 more 08 Feb 2022-Annual Review of Neuroscience 5 Citations	Synaptic signaling in cancer plays a crucial role by modulating neural structure and function to enhance growth-promoting signals in the tumor microenvironment, contributing to cancer progression.
Open access•Posted Content•DOI Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression Sol Savchuk, Kaylee Gentry, Wengang Wang, Elana Carleton, Belgin Yalçın, Yin Liu, Elisa C. Pavarino, Jenna LaBelle, Angus Toland, Pamelyn Woo, Fangfei Qu, Mariella G. Filbin, Mark A. Krasnow, Bernardo L. Sabatini, Julien Sage, Michelle Monje, Humsa S. Venkatesh - Show less +16 more 20 Jan 2023-bioRxiv 1 Citations	Synaptic signaling influences cancer growth by integrating malignant cells into neural circuits, promoting proliferation, invasion, and metastasis, as seen in small cell lung cancer brain metastases.
Journal Article•DOI Cnsc-17. glioma synapses recruit mechanisms of adaptive plasticity 01 Nov 2022-Neuro-oncology	Synaptic signaling, particularly through BDNF-TrkB pathway, drives malignant synaptic plasticity in gliomas, promoting tumor progression by enhancing synaptic strength and regulating neuron-to-glioma synapse numbers.

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What is the role of synapses in the nervous system?5 answersSynapses play a crucial role in the nervous system by facilitating the transmission of information between neurons. They are specialized points of contact between neurons where communication occurs. Synapses are responsible for regulating the physiological function of the body by allowing neurons to send signals to one another. They are highly dynamic structures that exhibit extensive plasticity, which is shaped by neural activity and regulated by trans-synaptic cell-adhesion molecules (CAMs). CAMs, such as neurexins (Nrxs) and neuroligins (Nlgs), directly regulate the assembly of presynaptic and postsynaptic molecules, including synaptic vesicles, active zone proteins, and receptors. The development and functioning of synapses are vital for normal nervous system function, and dysregulation of synapses can contribute to various neurological disorders. Understanding the structure and function of synapses is essential for developing therapeutic strategies for managing pathological conditions related to synaptic dysfunction.

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