What is trientine and copper binding affinity?
Best insight from top research papers
Trientine, also known as triethylenetetramine (TETA), is a copper-chelating agent used in various medical conditions. It has been studied for its ability to bind copper effectively, promoting copper redistribution and regulating copper levels in the body. Trientine forms stable complexes with copper, which can aid in copper scavenging from tissues and potentially alter copper homeostasis. Studies have shown that trientine treatment can reverse cardiac hypertrophy induced by copper deficiency by replenishing copper levels in the heart. Additionally, trientine has demonstrated potent inhibitory effects on tumor development and angiogenesis by chelating copper, leading to increased apoptosis in tumor cells and endothelial cells.
Answers from top 4 papers
More filters
| Papers (4) | Insight |
|---|---|
49 Citations | Trientine (TETA) is a copper-chelating agent used in Wilson's disease. Its metabolites, MAT and DAT, form stable Cu(II) complexes, with MAT showing high copper binding affinity. |
| Trientine (TETA) is a copper-selective chelator that delivers copper to the heart, reversing cardiac hypertrophy. The paper does not specify the exact binding affinity of trientine and copper. | |
| Trientine is a copper-chelating agent used in Wilson's disease. It suppresses tumor growth and angiogenesis in hepatocellular carcinoma by binding copper, inhibiting angiogenesis, and promoting apoptosis. | |
| Trientine is a copper chelating tetramine used to deliver copper to ischemic tissue, promoting tissue repair by increasing intracellular copper levels and enhancing copper-dependent activities like HIF-1 transcription. |
Related Questions
What are the factors that contribute to selective corrosion on copper wire bonding in electronic devices?5 answersSelective corrosion on copper wire bonding in electronic devices is influenced by various factors. Factors contributing to this corrosion include the presence of moisture, chlorine (Cl), and fluorine (F) which act as catalysts for intermetallic compound (IMC) corrosion. The Cu/Al ratio of the IMC plays a crucial role in determining the corrosion rate, with the most Cu-rich IMC being the most susceptible to corrosion. Additionally, the structural incompatibility between aluminum oxide and copper oxide compromises the passivity of the IMC surface oxide, making it less resistant to corrosion. Process parameters and steps during assembly also play a significant role in either facilitating or preventing corrosion on copper wire bonding. Therefore, controlling these factors through proper design and monitoring is essential to mitigate selective corrosion in semiconductor packages.
What are the types of ligand binding?5 answersLigand binding can occur through different mechanisms. One mechanism is simultaneous binding, where a divalent ligand binds to two identical monovalent molecules to form complexes. Another mechanism is selective binding, where metal ions selectively bind to their receptors at cell membranes. Ligand binding can also involve conformational transitions, with two main descriptions: induced fit and conformational selection. Induced fit assumes that conformational changes occur after the initial binding step to optimize the ligand-target complex, while conformational selection assumes that the free target exists in multiple conformations and the ligand selects the optimal one for binding. Ligand binding can also be influenced by factors such as linkage, where the binding of one ligand is influenced by the binding of another molecule of the same or different ligand, physical variables, or changes in macromolecular assembly state.
Why peptides binding affinity necessary?5 answersPeptides binding affinity is necessary for several reasons. Firstly, identifying tyrosine nitration in proteins, which is involved in many physiological and pathological processes, requires the pre-separation and enrichment of tyrosine-nitrated peptides (TNPs) before mass spectrometry analysis. Secondly, in the treatment of allergic airway diseases, peptide immunotherapy is a promising approach, and the identification of high affinity binding peptides can lead to potential candidates for this therapy. Thirdly, metal-binding peptides play a central role in bionanotechnology, and knowing the sequence modifications that enhance binding affinity is crucial for directing the growth and properties of inorganic nanomaterials. Lastly, understanding the binding affinity of peptides to major histocompatibility complex (MHC-I) is important for developing vaccines and precision medicine, and computational approaches can help in designing peptides with high binding affinity.
What is the Cu metal binding energy value?3 answersThe binding energy value of Cu metal is 7915.867(24) keV.
What kind of copper supplement should I take?3 answers
Which Copper peptide is best?6 answers