What research is available for people with panic disorder that don't adhere to medication due to side effects?
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Research suggests that individuals with panic disorder (PD) may struggle with medication adherence due to side effects. Studies have highlighted the high attrition rates among PD patients, with up to 50% discontinuing treatment despite effective pharmacotherapy options being available. Factors contributing to non-compliance include somatic iatrogenic side effects, such as vegetative hyper-reactivity, and psychological factors like phobic attitudes towards medications. While selective serotonin reuptake inhibitors (SSRIs) are effective for PD, their side effects, including sexual dysfunction and cognitive impairment, can lead to patient withdrawals from therapy. The need for safer yet effective drugs for treating PD is evident, with ongoing investigations exploring novel compounds like metabotropic glutamate (mGlu 2/3) agonists and levetiracetam as potential alternatives for treatment-resistant patients.
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| Papers (5) | Insight |
|---|---|
19 Citations | Agomelatine shows promise for panic disorder patients with medication non-adherence due to side effects, offering a potentially effective and well-tolerated treatment option. |
| Patients with panic disorder who don't adhere to medication due to side effects may benefit from addressing dissatisfaction with side effects and anxiety or fear related to taking medication. | |
15 Apr 2021 | Limited research suggests potential anti-panic effects of orexin receptor antagonists like JNJ-61393115 and xenon gas, offering alternatives for panic disorder patients averse to traditional medications due to side effects. |
14 Citations | Novel drugs like duloxetine, reboxetine, mirtazapine, nefazodone, risperidone, and inositol show promise for panic disorder patients resistant to standard medications due to better tolerability. |
| Not addressed in the paper. |
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