What's the effect of IL-1beta on MC3T3-E1?
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IL-1β has significant effects on MC3T3-E1 cells. It induces a decrease in cell viability, alkaline phosphatase activity, and osteoblast-related gene expression, while upregulating apoptotic markers like Bax and caspase-3 . Additionally, IL-1β in combination with 17β-estradiol decreases sensitivity to tamoxifen and increases multidrug resistance associated protein 2 (MRP2) expression, leading to tamoxifen resistance in estrogen receptor-positive breast cancer cells . On the other hand, IL-1β promotes osteoblast differentiation and calcification in MC3T3-E1 cells partly through AKT2-dependent pathways, enhancing the expression of osteogenesis-related markers like Runx-2, ALP, and osteocalcin . These findings highlight the dual role of IL-1β in regulating cell viability, apoptosis, drug resistance, and osteoblast differentiation in MC3T3-E1 cells.
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| Papers (5) | Insight |
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| IL-1β facilitates voltage sensitive Ca2+ channel current (I Ca) in MC3T3-E1 osteoblast cells, potentially influencing functions like growth, proliferation, and gene expression in bone remodeling. | |
| Not addressed in the paper. | |
| IL-1α induces apoptosis and inhibits osteoblast differentiation in MC3T3-E1 cells through JNK and p38 MAPK pathways, as shown in the study. | |
| Not addressed in the paper. | |
2 Citations | Not addressed in the paper. |
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