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Our data do not show a difference in vaccine effectiveness with age at vaccination and thus support the current recommendations for initial vaccination between 12 and 18 months of age.
In the race for creating a vaccine against COVID-19, immunosenescence is most likely to present a disincentive to the inclusion of older people in trials, and vaccine formulations effective in younger people (<65 years) might not engender immunity in older populations.
In conclusion, our results suggest a potential protective effect of the influenza vaccine on COVID-19 mortality in the elderly population.
Targeted interventions addressing age, sex, income, and education level are required to increase and sustain public acceptance of a COVID-19 vaccine.
The vaccine is highly effective and well tolerated in children and adults from 5 to 49 years of age.
Parents’ acceptability of COVID-19 vaccination for their children under 18 years of age was high in China.
Our findings support global recommendations to prioritize COVID-19 vaccine allocation for older age groups.
Age should be considered in vaccine recommendations.
Post-licensure vaccine efficacy is high among children > or = 2 years of age.
Extending the interval between COVID-19 vaccine doses may pose a risk to the elderly due to lower vaccine immunogenicity in this group.
We propose the immunological age as an independent risk factor to develop severe COVID-19.

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