Z
Zabrina L. Brumme
Researcher at Simon Fraser University
Publications - 257
Citations - 10523
Zabrina L. Brumme is an academic researcher from Simon Fraser University. The author has contributed to research in topics: Human leukocyte antigen & Viral load. The author has an hindex of 49, co-authored 222 publications receiving 9317 citations. Previous affiliations of Zabrina L. Brumme include Center for Excellence in Education & Massachusetts Institute of Technology.
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Journal ArticleDOI
Changes in Mitochondrial DNA as a Marker of Nucleoside Toxicity in HIV-Infected Patients
Hélène C. F. Côté,Zabrina L. Brumme,Kevin J. P. Craib,Christopher S. Alexander,Brian Wynhoven,Lillian Ting,Hubert Wong,Marianne Harris,P. Richard Harrigan,Michael V. O'Shaughnessy,Julio S. G. Montaner +10 more
TL;DR: Symptomatic hyperlactatemia was associated with marked reductions in the ratios of mitochondrial to nuclear DNA, which, during therapy, averaged 68 percent lower than those of non-HIV-infected controls and 43 percent lower Than those of HIV- infected asymptomatic patients never treated with antiretroviral drugs.
Journal ArticleDOI
Adaptation of HIV-1 to human leukocyte antigen class I
Yuka Kawashima,Katja Pfafferott,John Frater,Philippa C Matthews,Rebecca Payne,Marylyn M. Addo,Hiroyuki Gatanaga,Mamoru Fujiwara,Atsuko Hachiya,Hirokazu Koizumi,Nozomi Kuse,Shinichi Oka,Anna Duda,Andrew J. Prendergast,Hayley Crawford,Alasdair Leslie,Zabrina L. Brumme,Chanson J. Brumme,Todd M. Allen,Christian Brander,Christian Brander,Richard A. Kaslow,Jianming Tang,Eric Hunter,Susan Allen,Joseph Mulenga,S. Branch,T. Roach,Mina John,Simon Mallal,Anthony Ogwu,Roger L. Shapiro,Julia G. Prado,Sarah Fidler,Jonathan Weber,Oliver G. Pybus,Paul Klenerman,Thumbi Ndung'u,Rodney E. Phillips,David E. Heckerman,P.R. Harrigan,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Masafumi Takiguchi,Philip J. R. Goulder,Philip J. R. Goulder +46 more
TL;DR: This process of viral adaptation may dismantle the well-established HLA associations with control of HIV infection that are linked to the availability of key epitopes, and highlights the challenge for a vaccine to keep pace with the changing immunological landscape presented by HIV.
Journal ArticleDOI
Predictors of HIV Drug-Resistance Mutations in a Large Antiretroviral-Naive Cohort Initiating Triple Antiretroviral Therapy
P. Richard Harrigan,Robert S. Hogg,Winnie Dong,Benita Yip,Brian Wynhoven,Justin Woodward,Chanson J. Brumme,Zabrina L. Brumme,Theresa Mo,Christopher S. Alexander,Julio S. G. Montaner +10 more
TL;DR: High baseline pVLs and substantial but imperfect levels of adherence were major predictors of antiretroviral resistance.
Journal ArticleDOI
Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection
Matthew R. Henn,Christian L. Boutwell,Patrick Charlebois,Niall J. Lennon,Karen A. Power,Alexander R. Macalalad,Aaron M. Berlin,Christine M. Malboeuf,Elizabeth M. Ryan,Sante Gnerre,Michael C Zody,Rachel L. Erlich,Lisa Green,Andrew Berical,Yaoyu E. Wang,Monica Casali,Hendrik Streeck,Allyson K. Bloom,Tim Dudek,Damien C. Tully,Ruchi M. Newman,Karen L. Axten,Adrianne D. Gladden,Laura Battis,Michael Kemper,Qiandong Zeng,Terrance Shea,Sharvari Gujja,Carmen Zedlack,Olivier Gasser,Christian Brander,Christoph Hess,Huldrych F. Günthard,Zabrina L. Brumme,Chanson J. Brumme,Suzane Bazner,Jenna Rychert,Jake P. Tinsley,Kenneth H. Mayer,Eric S. Rosenberg,Florencia Pereyra,Joshua Z. Levin,Sarah Young,Heiko Jessen,Marcus Altfeld,Bruce W. Birren,Bruce D. Walker,Bruce D. Walker,Todd M. Allen +48 more
TL;DR: It is concluded that the early control of HIV-1 replication by immunodominant CD8+ T cell responses may be substantially influenced by rapid, low frequency viral adaptations not detected by conventional sequencing approaches, which warrants further investigation.
Journal ArticleDOI
Influence of HLA-C Expression Level on HIV Control
Richard Apps,Richard Apps,Ying Qi,Ying Qi,Jonathan M. Carlson,Haoyan Chen,Haoyan Chen,Xiaojiang Gao,Xiaojiang Gao,Rasmi Thomas,Yuko Yuki,Yuko Yuki,Greg Q. Del Prete,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder,Zabrina L. Brumme,Chanson J. Brumme,Mina John,Simon Mallal,George W. Nelson,Ronald J. Bosch,David Heckerman,Judy L. Stein,Kelly A. Soderberg,M. Anthony Moody,Thomas N. Denny,Xue Zeng,Xue Zeng,Jingyuan Fang,Ashley Moffett,Jeffrey D. Lifson,James J. Goedert,Susan Buchbinder,Gregory D. Kirk,Jacques Fellay,Paul J. McLaren,Steven G. Deeks,Florencia Pereyra,Bruce D. Walker,Nelson L. Michael,Amy C. Weintrob,Steven M. Wolinsky,Wilson Liao,Mary Carrington,Mary Carrington +45 more
TL;DR: It is demonstrated that increasing surface expression of HLA-C is associated with reduced viral load and reduced rate of progression to low CD4+ T cell counts in African and European Americans.