scispace - formally typeset
Search or ask a question

When sTREM-1 concentration increases? 

Protein kinase B
PI3K/AKT/mTOR pathway
Phagocytosis
Microglia
C-reactive protein
Best insight from top research papers

sTREM-1 concentration increases in various conditions such as Alzheimer's disease (AD) progression , Crimean Congo Haemorrhagic Fever (CCHF) infection , and in patients with severe COVID-19, especially those requiring ICU admission . In AD patients, sTREM-1 levels rise with disease severity and correlate with total tau levels . Similarly, CCHF patients exhibit elevated sTREM-1 levels compared to healthy controls, with levels decreasing upon recovery . Notably, in severe COVID-19 cases, higher sTREM-1 concentrations are associated with worse outcomes and increased mortality risk . These findings suggest that sTREM-1 levels increase in inflammatory and infectious conditions, reflecting disease severity and potentially serving as a marker for disease progression and prognosis.

Answers from top 5 papers

More filters
Papers (5)Insight
Journal Article•DOI
Serum sTREM‐1 level is quite higher in Crimean Congo Hemorrhagic Fever, a viral infection
Fatma Aybala Altay, Nazif Elaldi, Gönül Çiçek Şentürk, Nilgün Altın, Mustafa Gökhan Gözel, Yurdagul Albayrak, Irfan Sencan 
25 Feb 2016-Journal of Medical Virology
16 Citations
sTREM-1 concentration increases in Crimean Congo Hemorrhagic Fever (CCHF) viral infection, as shown by significantly higher levels in patients compared to healthy controls.
Journal Article•DOI
sTREM-1 in patients with chronic kidney disease on hemodialysis.
Enas S Essa, Khaled M. A. Elzorkany 
01 Nov 2015-Apmis
18 Citations
sTREM-1 concentration increases in chronic kidney disease patients on hemodialysis, correlating positively with CRP and TNF-α levels and negatively with hemoglobin concentration.
Journal Article•DOI
Soluble TREM1 concentrations are increased and positively correlated with total tau levels in the plasma of patients with Alzheimer’s disease
Teng Jiang, Pengyu Gong, Meng-Shan Tan, Xiao Xue, Shi Huang, Junshan Zhou, Lan Tan, Ying-Dong Zhang, Ying-Dong Zhang 
14 Jan 2019-Aging Clinical and Experimental Research
22 Citations
sTREM-1 concentrations increase in the plasma of Alzheimer's disease (AD) patients, with levels rising gradually during disease progression and showing a positive correlation with total tau levels.
Open access•Journal Article•DOI
Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19.
Aline H. de Nooijer, Inge Grondman, Simon Lambden, Emma J. Kooistra, Nico A F Janssen, Matthijs Kox, Peter Pickkers, Leo A. B. Joosten, Frank L. van de Veerdonk, Marc Derive, Sébastien Gibot, Mihai G. Netea, Mihai G. Netea 
30 Jul 2021-Bioscience Reports
11 Citations
sTREM-1 concentration increases in patients with severe COVID-19, particularly in those requiring ICU admission, and is higher in non-survivors compared to survivors.
Open access•Journal Article•DOI
sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K–AKT signaling pathway
PSPO-I PDF Exam Dumps, Suresh Kumar Subbiah, Holger Schwichtenberg 
29 Apr 2022-Dental science reports
5 Citations
sTREM-1 concentration increases during inflammation, as seen in neuropsychiatric systemic lupus erythematosus (NPSLE) patients, where elevated levels were observed, indicating its role in brain damage.

Related Questions

What is the relationship between stochastic processes and concentration fluctuations?5 answersStochastic processes play a crucial role in understanding concentration fluctuations in various systems. Different studies highlight how stochastic gene expression models, incorporating cell growth, division, and size-dependent gene expression, can predict noise in concentrations and the emergence of concentration homeostasis. Additionally, research on reversible reactions with random rate coefficients and activation energies demonstrates the evolution of concentration fluctuations over time, showing a universal power scaling law for probability density. Furthermore, the behavior of inertial particles in random velocity fields reveals unique concentration fluctuation characteristics, such as slow decay and correlation length differences, impacting the structure of velocity space and relative velocity variance. These findings collectively emphasize the intricate relationship between stochastic processes and concentration fluctuations across diverse systems.
Can antibiotic resistance effect sTREM-1 expression?4 answersAntibiotic resistance can affect the expression of sTREM-1. In patients with cystic fibrosis (CF), sTREM-1 levels were found to be elevated compared to healthy controls. Additionally, sTREM-1 levels positively correlated with protease levels, indicating a relationship between antibiotic resistance and sTREM-1 expression. These findings suggest that modulation of the TREM pathway, which includes sTREM-1, may be beneficial in treating CF patients with antibiotic resistance.
Is sTREM-1 value higher in patients with VAP caused by carbapenem-producing Pseudomonas aeruginosa?4 answerssTREM-1 levels were found to be significantly higher in patients with ventilator-associated pneumonia (VAP) in several studies. However, none of the abstracts specifically mentioned VAP caused by carbapenem-producing Pseudomonas aeruginosa. Therefore, there is no direct evidence from the provided abstracts to suggest that sTREM-1 levels are higher in patients with VAP caused by carbapenem-producing Pseudomonas aeruginosa.
What does the upregulation of SQSTM1 protein expression indicate?5 answersThe upregulation of SQSTM1 protein expression indicates impaired autophagy and is associated with various diseases including hepatocellular carcinoma (HCC). It is also linked to the misfolding and aggregation of TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis (ALS). In oral squamous cell carcinoma (OSCC), high co-expression of SQSTM1 and EGFR is associated with poor prognosis. Upregulating the Drosophila p62 homolog ref(2)P/dp62 delays the onset of pathology and prolongs healthy lifespan, suggesting a potential therapeutic target for counteracting aging. Additionally, SQSTM1/p62 is identified as an important regulator of mitochondrial DNA (mtDNA) expression machinery, promoting mtDNA expression and improving mitochondrial function.
What concentration of Streptomycin kills E. coli?3 answersStreptomycin kills E. coli at concentrations ranging from 4xMIC to 20 μg/ml. At 4xMIC, streptomycin induces cell death within an hour. The bactericidal effect of streptomycin is influenced by the carbon source and the presence of cyclic AMP or ATP in the growth medium. Glucose represses the bactericidal effect of streptomycin, while cyclic AMP reverses glucose repression and renders the cells sensitive to the drug. ATP can protect the cells against the bactericidal effect of streptomycin, but this effect can be abolished by the addition of cyclic AMP. At streptomycin concentrations above 20 μg/ml, the effects of glucose, cyclic AMP, and ATP are no longer measurable.
How does high sperm concentration affect fertility?5 answers

See what other people are reading

Can adaptogens like ashwagandha and rhodiola improve endurance and stress response in elderly nutrition?
10 answers
Adaptogens, including ashwagandha and rhodiola, have been recognized for their potential to enhance endurance and modulate stress response, which could be particularly beneficial in elderly nutrition. These natural compounds operate through a multi-targeted approach, affecting the immune-neuro-endocrine system and the hypothalamic–pituitary–adrenal axis, thereby enhancing the body's resistance to stress. Their biphasic dose-effect response activates adaptive stress-response signaling pathways, which could be crucial for improving adaptability, resilience, and survival under stress conditions. This mechanism is vital for elderly individuals who may experience diminished stress resilience and endurance due to aging. Specific studies on rhodiola and cordyceps, for instance, have shown improvements in body composition and endurance capacity, although these studies were conducted on young adults. However, the principles observed could be extrapolated to suggest potential benefits for the elderly, given the adaptogens' general mechanisms of action. For example, SHR-5, a standardized extract of Rhodiola rosea, has demonstrated significant effects in reducing tumor burden and improving survival rates in animal models, indicating its potent anti-aging properties. Similarly, Rhodiola rosea extract has shown to enhance neuronal ROS regulation and bioenergetics, which could support cognitive function and stress resilience in the elderly. Ashwagandha, on the other hand, has been shown to improve muscle strength, growth, and endurance in healthy adults engaged in resistance training, suggesting its potential to support physical performance and recovery, aspects that are often compromised in the elderly. Moreover, ashwagandha's antioxidant and anti-inflammatory actions, along with its ability to modulate neurotransmitter effects, could offer neuroprotective benefits and enhance adaptogenesis, making it a valuable component of elderly nutrition for managing stress and improving mental health. In conclusion, while direct studies on the elderly are limited, the available evidence from adaptogen research, including on ashwagandha and rhodiola, indicates promising potential for improving endurance and stress response in elderly nutrition. These adaptogens' multifaceted actions on stress pathways, anti-inflammatory, and antioxidant effects, along with their capacity to enhance physical and cognitive functions, suggest they could be beneficial in addressing the complex needs of the aging population.What are the haemolytic effects of nitrogen-doped carbon dots?
10 answers
Nitrogen-doped carbon dots (N-CDs) have emerged as a significant area of research due to their potential applications across various fields, including biomedicine and neuroscience. However, the haemolytic effects of these nanomaterials, or their impact on red blood cells, require careful consideration given their increasing exposure to the public and potential biosafety concerns. The synthesis of N-CDs, as described in various studies, involves methods that aim to enhance their fluorescence and quantum yield through nitrogen doping, which could influence their interaction with biological systems. Research focusing on the biomedical applications of N-CDs has shown promising results in terms of their low toxicity and high biocompatibility, which are crucial factors when considering the potential haemolytic effects. For instance, nitrogen-doped carbon dots synthesized for cell imaging and Fe3+ ion detection demonstrated good solubility, high quantum yield, and low cytotoxicity, suggesting minimal adverse effects on cell viability. Moreover, the ability of N-CDs to cross the blood-brain barrier in a concentration-dependent manner without significant cytotoxicity indicates a level of biocompatibility that could mitigate concerns about haemolytic effects. However, the adverse effects of N-CDs, particularly in the central nervous system, have been documented, including cell death and neuroinflammation in the hippocampus of mice, which raises questions about their safety profile. While these studies do not directly address haemolysis, they highlight the importance of evaluating the biosafety of N-CDs comprehensively. In summary, while the current literature primarily focuses on the synthesis, fluorescence enhancement, and potential applications of N-CDs, there is limited direct evidence regarding their haemolytic effects. The reported low toxicity and high biocompatibility in various studies suggest that N-CDs might have minimal haemolytic activity, but further research specifically addressing this aspect is necessary to fully understand their biosafety profile.What is the current understanding of the impact of ezetimibe on cancer risks?
5 answers
Ezetimibe, a drug used to reduce cholesterol absorption, has been extensively studied for its impact on cancer risks. Meta-analyses have shown that ezetimibe may increase the risk of intestine and breast cancers. However, overall, there is no significant evidence supporting a general increase in cancer risk with ezetimibe treatment. In fact, some studies suggest that ezetimibe could have anti-cancer effects, inhibiting cancer development and progression through various mechanisms. Genetic studies mimicking ezetimibe's effects also indicate no association between long-term NPC1L1 inhibition (like ezetimibe) and cancer risk, aligning with evidence from clinical trials. Therefore, while ezetimibe may have specific associations with certain cancers, the overall consensus leans towards its potential anti-cancer properties and a lack of substantial increase in cancer risks.What is the relationship between spinal nerves and abdominal pain?
5 answers
Spinal nerves play a crucial role in the genesis of chronic abdominal pain, especially in conditions like inflammatory bowel disease (IBD). Research indicates that sensory nerve information from the bowel is encoded and transmitted to the brain through intrinsic enteric afferents and extrinsic nervous networks, including vagal, pelvic, and splanchnic afferents. In cases of chronic abdominal pain, such as in IBD and irritable bowel syndrome (IBS), long-term neuroplastic changes occur in the brain-gut axis, leading to hypersensitivity and chronic pain. Additionally, studies suggest that spinal cord microglia activation and purinergic signaling in spinal microglia are involved in the development of visceral hyperalgesia and chronic postinflammatory pain, indicating a link between spinal nerves and abdominal pain.Why does heart rate increase during exercise?
4 answers
The increase in heart rate during exercise is primarily due to a combination of neural and hormonal control mechanisms. Initially, at the onset of exercise, there is a reduction in parasympathetic neural activity, leading to an increase in heart rate. Subsequently, sympathetic neural drive is heightened, further elevating the heart rate. This response is mediated by the withdrawal of vagal tone, increased sympathetic tone, and the action of circulating catecholamines. Additionally, genetic studies have shown that the acute and long-term heart rate response to exercise is heritable, with various genes associated with heart rate increase and recovery during exercise. Therefore, the increase in heart rate during exercise is a complex interplay of neural, hormonal, and genetic factors.How does the progression of multiple sclerosis vary among different demographic groups, such as age, gender, and ethnicity?
5 answers
The progression of multiple sclerosis (MS) varies among different demographic groups. Gender plays a role, with males showing faster disability progression compared to females, potentially due to increased neurodegeneration processes. Age at MS onset also influences progression, with older age correlating with shorter time to secondary progressive MS diagnosis. Ethnicity, specifically in Hispanic and Black populations, impacts long-term outcomes, with lower survival times and higher rates of disease progression observed compared to White patients. Factors such as active lesions, cerebellar complications, being male, and having concomitant neurological diseases are associated with increased risk of disability progression, while relapsing-remitting MS and younger age at diagnosis are protective factors. These findings highlight the complex interplay of demographic factors in shaping the course of MS progression.How lead (Pb) affects glicolisis?
5 answers
Lead (Pb) exposure impacts glycolysis through various mechanisms. Pb inhibits microglia cell proliferation and multinucleation, potentially affecting energy metabolism pathways like glycolysis. Additionally, Pb exposure alters gene expression patterns by modulating DNA methyltransferase (DNMT) activity, which can lead to changes in global DNA methylation levels. Furthermore, polymorphisms in genes related to antioxidant status and Pb metabolism influence Pb levels in blood and plasma, potentially affecting glycolysis indirectly through oxidative stress regulation. These combined effects of Pb exposure on cellular processes, gene expression, and antioxidant responses suggest a complex interplay that could impact glycolysis and overall cellular metabolism.What is the effect of neonicotinoid insecticides and lipase, amylase, and glucose level?
5 answers
Neonicotinoid insecticides have various effects on biological systems. They can inhibit lipase and amylase activity in insects, affecting their metabolism and nutrition processes. Additionally, neonicotinoids like imidacloprid have been shown to induce insulin resistance by impacting the insulin signaling cascade in different cell models, leading to reduced glucose uptake. Furthermore, exposure to neonicotinoids can cause biochemical and histopathological alterations in nontarget vertebrates, such as Egyptian toads, affecting their lipid profile, liver enzymes, and oxidative stress markers. Interestingly, neonicotinoids have been found to have adipogenic effects in mammalian cell cultures, with imidacloprid stimulating lipid accumulation, possibly mediated via the pregnane X receptor. These findings highlight the diverse impacts of neonicotinoids on different biological processes.Do plasmalogen content in tissues decline with age?
5 answers
Plasmalogen content in tissues does decline with age, as supported by various research studies. Studies have shown that plasma choline plasmalogen levels decrease with age, particularly in relation to factors of atherosclerosis. Additionally, in aged female mice, supplementation with plasmalogens led to improved cognitive performance, synaptic plasticity, and neurogenesis, indicating a potential intervention strategy for halting neurodegeneration and promoting neuroregeneration. Furthermore, the reduction of plasmalogens has been associated with age-related neurodegenerative diseases like Alzheimer's disease, emphasizing the importance of these lipid species in maintaining neural health. Overall, the data from these studies collectively suggest a decline in plasmalogen content in tissues with age, highlighting the significance of these molecules in aging and age-related diseases.How to measure PI3K/AKt activity?
5 answers
To measure PI3K/Akt activity, various methods have been proposed in the literature. One approach involves utilizing a genetically-encoded fluorescent kinase translocation reporter to visualize and quantify Akt activity in live cells over time. Another method suggests using specific antibodies conjugated with quantum dots to assess the phosphorylation states of proteins in the AKT signaling pathway, particularly in colorectal cancer patients with PTEN loss. Additionally, a test has been developed to provide a quantitative PI3K pathway activity score based on measuring FOXO transcription factor target gene mRNA levels, offering a way to predict drug response and resistance to targeted therapies. Furthermore, a multiplex immunoassay has been described to quantitate isoform-specific phosphorylation of proteins in the PI3K/AKT pathway, allowing for the assessment of pharmacodynamic changes in response to targeted agents.Can FOXO1 suppress NFkB signaling?
5 answers
Yes, FOXO1 can suppress NF-κB signaling. Research indicates that FOXO1 activation inhibits NF-κB in various contexts. In gastric cancer, FOXO1 was found to be a negative upstream regulator of NF-κB, with overexpression of FOXO1 suppressing NF-κB activation. Additionally, in a study on bone marrow-derived mesenchymal stem cells, it was shown that FOXO1 plays a role in defending against oxidative damage, and its decline due to estrogen deficiency led to NF-κB activation, contributing to oxidative damage and stem cell dysfunction. Furthermore, FOXO1 agonists were found to promote osteogenesis by inhibiting NF-κB activation under inflammatory conditions, suggesting a protective effect on bone formation by modulating multiple signaling pathways. These findings collectively support the notion that FOXO1 can indeed suppress NF-κB signaling in different biological contexts.