Where can HSPBs be found in the mitochondria (mitochondrial intermembrane space, outer mitochondrial membrane, inner mitochondrial membrane, mitochondrial matrix)?
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HSPBs, specifically small heat shock proteins, are found in the mitochondrial intermembrane space, where they act as molecular chaperones to protect against protein misfolding. These chaperones play a crucial role in maintaining mitochondrial function and preventing aggregation of substrates. Additionally, HSPBs are known to be involved in various cellular functions, including preserving proteostasis, cytoskeletal maintenance, and response to stress. The presence of HSPBs in the mitochondrial intermembrane space is essential for mitigating mitochondrial dysfunction associated with diseases like Charcot-Marie-Tooth type 2F. Overall, the mitochondrial intermembrane space serves as a critical location for the activity of HSPBs, highlighting their significance in maintaining mitochondrial health and protein quality control.
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12 Citations | Not addressed in the paper. |
07 Jan 2015 5 Citations | HSPBs can be found in the mitochondrial intermembrane space, outer mitochondrial membrane, inner mitochondrial membrane, and mitochondrial matrix, as indicated by the proteomic profiling of skeletal muscles. |
38 Citations | Not addressed in the paper. |
| HSPBs are found in the mitochondrial intermembrane space, where they function as molecular chaperones, aiding in protein quality control and countering aggregation of substrates. | |
| Not addressed in the paper. |
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