Showing papers on "Aldose published in 1979"
TL;DR: Findings indicate that the evaluation of aldose reductase inhibitors for potential clinical use may require the use of human aldosing reductases from the appropriate target tissue.
Abstract: The potency of the aldose reductase inhibitors 3,3-tetramethylene glutaric acid, 1, Alrestatin, 2, quercitrin, 3, T-hydroxy-4-oxo-4H-chromen-2-carboxylic acid, 4, its ethyl ester, 5, and 2-tetrazolyl-3-chloro-4-oxo-4H-chromen, 6, was evaluated against human placental aldose reductase prepared via affinity column chromatography. The order of potencies obtained was 4 >5 >2 >3 >1 > 6. This did not correlate with the order obtained against rat lens aldose reductase which was 3 >2 > 4 = 5 = 1=6. Except for 7-hydroxy-4-oxo-4H-chromen-2-carboxylic acid, 4, all compounds displayed decreased inhibition against human placental aldose reductase as compared to rat lens aldose reductase. These findings indicate that the evaluation of aldose reductase inhibitors for potential clinical use may require the use of human aldose reductase.
77 citations
TL;DR: Three-, four-, and five-carbon aldononitrile phosphates were prepared, purified, and catalyticlly reduced with palladium--barium sulfate to the corresponding aldose phosphates in high yields at pH 1.7 +/- 0.1 and atmopsheric pressure.
Abstract: Three-, four-, and five-carbon aldononitrile phosphates were prepared, purified, and catalyticlly reduced with palladium--barium sulfate (5%) to the corresponding aldose phosphates in high yields at pH 17 +/- 01 and atmopsheric pressure DL-Glyceraldehyde 3-phosphate and the tetrose 4-phosphates were prepared with carbon-13 enrichment at C-1, while the pentose 5-phosphates were prepared with enrichment at C-1 and C-2 Preparations of glycolaldehyde phosphate and d-glyceraldehyde 3-phosphate by lead tetra-acetate oxidation of glycerol phosphate and fructose 6-phosphate, respectively, are described The proportions of cyclic hemiacetals and linear gem-diol forms of the two- to five-carbon aldose phosphates in aqueous solution are reported Carbon-13 chemical shifts and carbon--phosphorus and carbon--hydrogen coupling constants for the furanose phosphate ring and linear gem-diol phosphates are reported and discussed d-[2(-13)C]Ribulose 1,5-bisphosphate and L-[3,4(-13)C]sorbose 1,6-bisphosphate were prepared enzymatically from D-[2(-13)C]ribose 5-phosphate and dl-[1(-13)C]glyceraldehyde 3-phosphate, respectively
63 citations
TL;DR: In this article, the kinetics of chromic acid oxidation of d -galactose, d -mannose, l -arabinose, and d -xylose have been studied in perchloric acid media.
45 citations
TL;DR: In this paper, peracetylated aldononitrile derivatives from aldoses have been examined and correlations have been made between changes in g.l.c. retention-times and changes in the stereochemistry and functional groups of the parent aldose.
40 citations
TL;DR: In this paper, a procedure for the preparation of aldoses and aldose phosphates enriched with 2H by hydrogenolysis of aldononitriles and aldononiitrile phosphates over palladium using 2H2 was described.
Abstract: A procedure is described for the preparation of aldoses and aldose phosphates enriched with 2H by hydrogenolysis of aldononitriles and aldononitrile phosphates over palladium using 2H2. Aldoses, al...
40 citations
36 citations
TL;DR: In this article, the effect of temperature on d-glucose-to-d-fructose conversion was studied; lower temperatures give the higher maximum yields, while higher yields are not possible at this temperature because of a marked tendency for maltulose to undergo elimination of d-Glucose at C-4.
35 citations
TL;DR: In this paper, the proton chemical shifts of the glycosidic protons have been measured for solutions of oligosaccharides in D 2 O; to some degree, the shifts are diagnostic of both the nature of the sugar and of the type of linkage.
23 citations
TL;DR: In this paper, the 4-aldose d -aldose diethyl dithioacetals (1a-d ) were treated with bromine to give the corresponding, unstable 1-bromides, which were immediately condensed with 6-chloro-9-(chloromercuri)purine (3) to furnish the respective, protected nucleosides.
8 citations
Patent•
09 Mar 1979
TL;DR: In this paper, the authors proposed to obtain a ketose for sweetening agents with a high isomerization ratio, by isomerizing an aldose, using a specific highly active compound, e.g. sodium dimethyldithiocarbamate, sodium pyrrohidinodithiamine, etc. as a novel catalyst.
Abstract: PURPOSE:To obtain a ketose for sweetening agents with a high isomerization ratio, by isomerizing an aldose, using a specific highly active compound, e.g. sodium dimethyldithiocarbamate, sodium pyrrohidinodithiocarbamate, etc. as a novel catalyst.
4 citations