Showing papers on "Chronic stress published in 1981"
TL;DR: Chronic stressed rats showed endocrine changes similar to those seen in human depressives, and antidepressant treatment with the monoamine oxidase inhibitor pargyline restored the ability of chronically stressed rats to respond actively to stress.
819 citations
TL;DR: Examination of plasma corticosterone titers indicated that chronic stress induced an elevation of basal levels and that this was reversed by amitriptyline, scopolamine, and combined drug treatment, indicating that behavioral depression and elevated corticosteroids may covary, but are not identically mediated.
88 citations
TL;DR: Imipramine restored both behavioral and psychoendocrine activity which was otherwise altered by chronic stress and extended results upon treatment to the class of tricyclic antidepressant drugs, using imipramines as a prototypic tricyClic antidepressant.
74 citations
TL;DR: It seems that stress, by increasing intrasynaptic norepinephrine levels resulting from an accelerated turnover rate, causes β-adrenergic receptor subsensitivity in the corter, which appears to be due to a decreased number of receptors.
57 citations
TL;DR: The present studies show that footshock-induced subsensitivity is not related to changes in either beta or alpha-1 adrenergic receptors, phosphodiesterase or total adenylate cyclase activity, and indicate that the mechanism of subsensitivity after chronic stress resembles in part that seen after antidepressants but may also involve additional phenomena which may not occur after the latter agents.
Abstract: Chronic footshock stress in rats produces a persistent reduction in the sensitivity of the norepinephrine (NE)-cAMP generating system in the cerebral cortex, an effect similar to that reported after chronic antidepressant treatment. The present studies show that footshock-induced subsensitivity is not related to changes in either beta or alpha-1 adrenergic receptors, phosphodiesterase or total adenylate cyclase activity. The stress does induce a small, selective decrease in binding at high affinity alpha-2 receptor sites but this change does not appear to explain the decreased responsiveness to NE. These data and related findings by others using restraint stress indicate that the mechanism of subsensitivity after chronic stress resembles in part that seen after antidepressants but may also involve additional phenomena which may not occur after the latter agents.
31 citations
TL;DR: Depressive illness was associated with significantly lower post-menopausal urinary oestrogen excretion than was found in a control group of normal healthy women, and there was a trend, which did not reach significance, towards higher urinary oestro levels in two surgical groups than in the normal healthy group.
5 citations
TL;DR: Chronic treatment with diazepam was effective in preventing chronic stress-induced hypertension in rats and prevented the stressful stimuli from maintaining a hypertensive level in animals previously made hypertensive by chronic stress.
Abstract: Chronic treatment with diazepam was effective in preventing chronic stress-induced hypertension in rats. It also prevented the stressful stimuli from maintaining a hypertensive level in animals previously made hypertensive by chronic stress.
3 citations
3 citations
Journal Article•
TL;DR: The drastic increase in tyrosine hydroxylase activity in the hypothalamus and striatum after stress correlates with disturbances in behavior, somatic defects in "em emotional" rats as compared with "non-emotional" ones.
Abstract: The relationship between behavior manifestations, somatic alterations and brain tyrosine hydroxylase activity was studied in "emotional" and in "non-emotional" rats exposed to chronic stress. The drastic increase in tyrosine hydroxylase activity in the hypothalamus and striatum after stress correlates with disturbances in behavior, somatic defects (ulcers, erosions) in "emotional" rats as compared with "non-emotional" ones.
1 citations
Journal Article•
01 Dec 1981-Agressologie: revue internationale de physio-biologie et de pharmacologie appliquées aux effets de l'agression
1 citations
01 Jan 1981
TL;DR: Chronic stress produced by the daily subcutaneous injection of immature mice with saline produced an increase in the sensitivity of these mice, when tested at maturity, to morphine-analgesia, and chronic exposure to narcotic antagonists during development increased the latency of response to a painful stimulus.
Abstract: Chronic stress, produced simply by the daily subcutaneous injection of immature mice with saline, produced an increase in the sensitivity of these mice, when tested at maturity, to morphine-analgesia (MA). In addition, chronic exposure to narcotic antagonists during development, using the same injection schedule, increased the latency of response to a painful stimulus.