Showing papers on "High Shear Granulation published in 2020"
TL;DR: In this paper, the authors deal with the creation of a mathematical model which will predict with sufficient accuracy the size of granules in the high-shear granulation process, and the aim of the paper was to create...
Abstract: This work deals with the creation of a mathematical model which will predict with sufficient accuracy the size of granules in the high-shear granulation process. The aim of the paper was to create ...
14 citations
TL;DR: In this article, the authors compared continuous twin-screw granulation with batch-wise high-shear granulation (HSG) and found that TSG is a good alternative to HSG.
14 citations
TL;DR: The aim of the review is a critical discussion of proposed regime maps for different granulation processes, which ensure a reduction of both the experimental workload and the number of parameters that have to be considered.
14 citations
TL;DR: It was concluded that the GS was the most important QA for dissolution in the HSG-TSG process, and TSG tablets showed higher tensile strength and lower ejection force than HSG tablets.
13 citations
TL;DR: This study concludes that understanding the effect of mannitol grade is a crucial part of formulation selection.
11 citations
01 Jan 2020
TL;DR: Two numerical methods, that is, population balance model (PBM) and discrete element method (DEM), are chosen for the multiscale modeling of twin screw granulation, and their coupling mechanisms of data exchange between DEM and PBM are discussed.
Abstract: Wet granulation is a critical unit operation in solid dosage form manufacturing in the pharmaceutical industry. Traditionally, wet granulation has been a batch process. Recently, there has been a move toward more advanced manufacturing approaches such as continuous processing to allow more rigorous process control, consistent quality assurance, and reduced capital costs. This chapter discusses continuous wet granulation process with emphasis on twin screw granulation as the most commonly used continuous granulation approach in the pharmaceutical industry. The key design features of a twin screw granulator (TSG) are described, and comparisons with batch high shear granulation equipment are made. The effects of formulation and process variables on granule attributes are discussed. Mechanistic studies of screw elements with the proposed granulation rate processes are presented. Real-time process monitoring tools, including spectroscopic and imaging techniques, are described. Implementation of dimensional analysis as a tool for scaling up/scaling out of continuous twin screw granulation is presented. Two numerical methods, that is, population balance model (PBM) and discrete element method (DEM), are chosen for the multiscale modeling of twin screw granulation, and their coupling mechanisms of data exchange between DEM and PBM are discussed.
6 citations
TL;DR: This study examined a process conversion from batch based high-shear wet granulation (HSWG) to continuous RC manufacturing, without any significant formulation changes and concluded that in the future, if a good product/process understanding of the alternative manufacturing process with different techniques can be obtained, it will be possible to devise more flexible and effective ways to allow the pharmaceutical industry to switch from batch manufacturing towards CM.
3 citations