Showing papers in "International Journal of Pharmaceutics in 2020"

TL;DR: In this review, even if it is virtually impossible to list all the commercial products based on hydrogels for biomedical applications, an extensive analysis of those materials that have reached the market has been carried out.

TL;DR: The current state-of-the-art in SLS 3D printing is reviewed, including the main principles underpinning this technology and the diverse selection of materials and essential parameters that influence printing are highlighted.

TL;DR: A critical review of hand sanitation approaches and products available on the market in light of the scientific evidence available to date is presented and a range of hand sanitisation product formulations are provided to allow for extemporaneous preparations at the community and hospital pharmacies during this urgent crisis.

TL;DR: This review discussed the methodologies of preparation and characterization of ASDs with an emphasis on understanding and predicting stability, and rational selection of polymers, preparation techniques with its advantages and disadvantages and characterize of polymeric amorphous solid dispersions.

TL;DR: Graphical abstract Polymer microneedle promotes the delivery of chemical and biological drugs through the skin through its role in cell reprograming and wound healing.

TL;DR: This review focused in providing examples of dendrimers used in nanomedicine, with a total of six derivatives in clinical trials and seven products available in the market.

TL;DR: It was confirmed that HA could be an effective carrier for both topical and transdermal deliveries due to its unique viscoelasticity, biocompatibility, biodegradability, non-immunogenicity, and biomedical benefits for the skin.

TL;DR: M3DISEEN, a web-based pharmaceutical software, was developed to accelerate FDM 3D printing, which includes producing filaments by hot melt extrusion (HME), using AI machine learning techniques (MLTs), and achieved high levels of accuracy by solely inputting the pharmaceutical excipients.

TL;DR: This review will describe the application of GO and rGO within 3D scaffolds in bone, cardiac and neural regenerative medicine after analyzing the aforementioned challenges.

TL;DR: This review summarizes various multifunctional polymeric nano-sized formulations such as polymer-based super paramagnetic nanoparticles, ultrasound-triggered polymeric nanop articles,polymeric nanoparticles bearing radionuclides, and fluorescent polymeric Nano- sized formulations for purpose of theranostics.

TL;DR: The need for a careful formulation design to exploit the best properties of this drug delivery system as well as the development of manufacturing processes easily scalable at industrial level is brought out.

TL;DR: Results disclosed that NLC gel could be used as a potential carrier for the delivery of quercetin & resveratrol into deeper layers of the skin and can serve as a promising formulation for treatment of skin cancer.

TL;DR: Results from the animal model of PD show that intranasally-administered RNPs enhanced brain targeting efficiency and drug bioavailability and RNPs for nose-to-brain delivery has significant potential to be developed as a treatment approach for PD.

TL;DR: The integrated patch produced in this work represents a promising minimally invasive transdermal drug delivery system that can overcome the skin barrier and deliver MTX in a sustained manner, which may help in minimising or even avoiding the nausea and vomiting, associated with the conventional administration routes.

TL;DR: Compared with free DOX, superior in vivo anti-tumor efficacy of HA-CD@p-CBA-DOX was observed in both heterotopic and orthotopic 4T1 cell tumor models, and blood hematology and blood biochemistry analysis demonstrated that haemocompatibility and serum stability were good and DOX-loaded nanoparticles did not induce noticeable toxicity.

TL;DR: St stereolithography 3D printing is used to create custom tablet geometries using a novel biocompatible photochemistry consisting of ascorbic acid encapsulated in a poly(ethylene glycol) dimethacrylate (PEGDMA)-based polymer network and polymerized using riboflavin as a photoinitiator, and it is shown that it is possible to successfully load and release ascorBic acid as a model agent.

TL;DR: This review summarizes numerous applications for 3D printing in building drug-loaded structures including tablets, scaffolds, implants, microneedles, capsules, films, hydrogels, mouthguards, tubes, stents, vaginal suppositories and rings as well as in pediatric field.

TL;DR: The significant variation of physical and biological properties of these composite scaffolds with trace changes in the content of the Au dopant inside the ceramic filler particles is promising, as it provides a new, relatively subtle avenue for tailoring the properties of tissue engineering scaffolds for their intended biomedical applications.

TL;DR: This review focuses on microneedle systems that are either on the market or in clinical trials, their applicability and characteristics, and the critical evaluation and test methods necessary for their development and approval.

TL;DR: In vivo tests on full-thickness rat models revealed that fabricated nanofibers accelerate wound contraction, increase collagen deposition and angiogenesis, and prevent scar formation, and showed that fabricated scaffolds are promising candidates for treatment of full-Thickness wounds.

TL;DR: The results demonstrate the surface composition and functionality of EVs can be tuned by extrusion with lipids and suggest the engineered vesicles can be a potential substitute as gene delivery carriers while being able to be mass produced to a greater degree with retained targeting capabilities of EVs.

TL;DR: A stepwise discussion of techniques useful to screen and select polymers suitable for hot melt extrusion processing are explored and reported and a higher degree of accuracy is provided towards the development of efficient, stable, and consistent products.

TL;DR: This work provides an insight of the novel approaches in drug delivery covering the critical comparison between traditional and novel “advanced-designed” systems.

TL;DR: A systematic review methodology based on the application of this novel technology in the field of drug delivery along with the manufacturing of polypills with varied release profiles and geometries is carried out.

TL;DR: For the first time, a non-destructive, RTR quality control of two separate active ingredients in a single 3D printed drug product using NIR spectroscopy is reported, overcoming a major barrier to the integration of 3D printing into clinical practice.

TL;DR: An extensive overview of AM technologies and their applications for drug delivery is provided including their working principles, processed materials, as well as current progress in drug delivery to produce personalized dosages for every patient with controlled release profile.

TL;DR: The results showed that the PTX-Micelles system could alter the in vivo pharmacokinetic performance and therapeutic effect of PTX via its predesigned functions, and an enhanced anti-lung tumor efficacy of PTx was observed when compared to Taxol®.

TL;DR: Versatility of FDM, especially in terms of geometric freedom provided, was highlighted together with some limitations that still need to be addressed, as expected for a newly-adopted fabrication technique that holds potential for being implemented in the pharmaceutical field.

TL;DR: The proposed dexamethasone-glycol chitosan nanoparticles showed good ocular tolerance and provided a relatively longer precorneal duration compared with that of the aqueous solution formulation, which suggested that the self-assembled Dex-GCS nanoparticle might be a promising candidate for ophthalmic drug delivery.

TL;DR: This work confirms that defined liposome products can be manufactured rapidly and reproducibly using a scale-independent production process, thereby de-risking the journey from bench to approved product.