Showing papers on "Hypersensitivity reaction published in 1971"
TL;DR: The results of this study indicate that the RAST is a valuable alternative to the more dangerous intracutaneous test with penicilloyl‐polylysine for‐detection of penicillin hypersensitivity of the immediate type.
Abstract: Summary
Reaginic antibodies (IgE) to penicilloyl were detected by an in vitro method, a radioimmunological technique (RAST), in the sera of nine patients out of eleven with a recent history of penicillin hypersensitivity of the immediate type. Provocation tests in two patients with negative RAST were negative as well as in twelve patients having had a possible penicillin hypersensitivity reaction 7 months to 14 years ago. Results from skin tests and RAST agreed. Skin tests and RAST reactions were negative for thirty-two patients with a history of penicillin reactions of the delayed type. The results of this study indicate that the RAST is a valuable alternative to the more dangerous intracutaneous test with penicilloyl-polylysine for-detection of penicillin hypersensitivity of the immediate type.
81 citations
TL;DR: Observations suggest that hypersensitivity to allopurinol can produce a severe, prolonged, or potentially fatal illness.
Abstract: Two patients developed fever, dermatitis, renal insufficiency, and eosinophilia, three and five weeks after beginning therapy with allopurinol. The clinical, laboratory, and histologic findings were compatible with a severe hypersensitivity reaction. Both patients required long-term corticosteroid therapy (more than six and four months, respectively) to control their symptoms. These observations suggest that hypersensitivity to allopurinol can produce a severe, prolonged, or potentially fatal illness.
79 citations
TL;DR: Evidence indicates that there is a partial impairment of the delayed hypersensitivity reaction in some patients with alcoholic cirrhosis of the liver, and complete impairment to the antigens employed in a lesser number.
Abstract: Since there is evidence for an increased incidence of infection in patients with alcoholic cirrhosis of the liver, a study was performed to determine whether or not impairment of delayed hypersensitivity reaction was a contributory factor. Fifty consecutive patients with alcoholic cirrhosis were studied. The dermal antigens employed were DNCB (2,4-dinitro-1-chlorobenzene), PPD, histoplasmin, streptokinase-streptodornase, coccidioidin and candida. Thirty-two percent of the patients could not be sensitized to DNCB, in contrast to an expected number of 5% in control groups (X2>9,P<0.01). Of the 50 patients tested, 7 reacted negatively to all the antigens including DNCB. No significant difference in reaction was found between the patients and the controls for coccidioidin, histoplasmin, PPD, candida or streptokinase-streptodornase. This evidence indicates that there is a partial impairment of the delayed hypersensitivity reaction in some patients with alcoholic cirrhosis of the liver, and complete impairment to the antigens employed in a lesser number.
70 citations
TL;DR: The pathologic and immunologic findings confirmed that this condition is due to hypersensitivity reaction to A. fumigatus, and there is little evidence in this study of the type III reaction from the pathology and the immunofluorescent staining.
66 citations
Journal Article•
TL;DR: A case is reported in which the number of proliferating blast-like cells substantially increased in peripheral blood during hypersensitivity reaction to carbamazepin (`Tegretol').
Abstract: A case is reported in which the number of proliferating blast-like cells substantially increased in peripheral blood during hypersensitivity reaction to carbamazepin (`Tegretol'). The patient's lymphocytes subsequently transformed in vitro into blasts in the presence of carbamazepin. In provocation tests, two patients with carbamazepin hypersensitivity showed a significant increase in proliferating blasts in the peripheral blood.
34 citations
TL;DR: A gradually progressive, exudative, pneumonic process occurred in the lungs after inhalation of PPD, which was maximal after approximately 24 hours to 48 hours and gradually subsided in the ensuing 7 days to 20 days.
Abstract: Purified protein derivative (PPD) was inhaled by guinea pigs immunized by an injection of dry-killed tubercle bacilli. The animals showed no sign of acute respiratory distress during the inhalation...
23 citations
Journal Article•
TL;DR: Ribosomal material sensitized guinea pigs not only against the specific ribosomal protein but also against PPD, and its activity was destroyed by pronase treatment but resisted heat treatment.
Abstract: The tuberculin activity of ribosomal material isolated from BCG was studied. Ribosomal material was able to induce delayed-type hypersensitivity reactions in BCG-sensitized guinea pigs, in addition to early inflammatory reactions in both BCG-sensitized and non-sensitized animals. Ribosomal RNA and protein were isolated from the above material and their tuberculin activity was studied. Whereas purified RNA was unable to elicit any inflammatory reaction, ribosomal protein did induce a delayed-type hypersensitivity reaction in BCG-sensitized guinea pigs. No early inflammatory reactions were observed with the latter material. In addition, ribosomal protein sensitized guinea pigs not only against the specific ribosomal protein but also against PPD. Its activity was destroyed by pronase treatment but resisted heat treatment.
21 citations
TL;DR: Patients with heavy proteinuria also developed oedema and hypoalbuminaemia, but all of these manifestations subsided when the drug was discontinued, a short course of corticosteroid treatment being given in some cases.
Abstract: The results of using N -acetyl- D -penicillamine for the treatment of cystinuria for periods of between 7 months and 2·75 years are reported and compared with those obtained when D -penicillamine is employed.
Both drags reduce the urinary excretion of cystine and their effective doses are similar.
The main side effects encountered were an acute hypersensitivity reaction and proteinuria which developed later and which could not be related to the presence of calculi or infection. Only one mild acute hypersensitivity reaction occurred in the nine patients who took N -acetyl- D -penicillamine. Ten of the 19 patients who were treated with D -penicillamine developed more severe acute hypersensitivity reactions. Desensitization to the drug could, however, be accomplished under cover of prednisolone.
Proteinuria occurred with about equal frequency and severity with both drugs and although it may be heavy, it does not appear to make the renal prognosis markedly worse. Some of the patients with heavy proteinuria also developed oedema and hypoalbuminaemia, but all of these manifestations subsided when the drug was discontinued, a short course of corticosteroid treatment being given in some cases. It was possible to continue treatment in patients with a relatively mild degree of proteinuria in whom there was a very strong indication for doing so.
20 citations
TL;DR: The clinical and histological findings of 2 patients with acute febrile neutrophilic dermatosis are described and Associated clinical features suggest that a hypersensitivity reaction is responsible for this illness.
Abstract: The clinical and histological findings of 2 patients with acute febrile neutrophilic dermatosis are described. Associated clinical features in 1 case suggest that a hypersensitivity reaction is responsible for this illness.
16 citations
TL;DR: Positive results were obtained with aminophylline as well as with anti-IgE, suggesting that the immediate reaction observed may have been mediated by aminphylline, which could be passively transferred using the Prausnitz-Kustner procedure.
Abstract: A twelve-year-old asthmatic boy is reported who had a urticarial reaction associated with generalized pruritus following the intravenous administration of aminophylline. An identical clinical reaction occurred after a fortuitous challenge with a second dose of the drug. An immediate wheal and flare reaction to aminophylline was obtained, which could be passively transferred using the Prausnitz-Kustner procedure. To confirm the immunologic nature of the reaction, the rat mast cell degranulation technique was applied using the patient's serum and aminophylline or anti-IgE. Positive results were obtained with aminophylline as well as with anti-IgE, suggesting that the immediate reaction observed may have been mediated by aminophylline. Whether the IgE detected by this method was specific or not for aminophylline is not established.
8 citations
TL;DR: Conditions for the induction and the phases of development of this hypersensitivity to LPS and for anti-infectious resistance were shown to be different and present and previously obtained results suggest that the antigens participating in each of these two conditions were different.
Abstract: Mice infected with various strains of Salmonella enteritidis and S. typhimurium were found to be more sensitive to the cell wall lipopolysaccharide (LPS) extracted from certain strains of Salmonella than noninfected mice. This hypersensitivity was induced by those smooth or rough strains which possessed a polysaccharide chain longer than that of a glucoseless mutant. The major antigenic group participating in this hypersensitivity was presumed to be in rough core polysaccharide sequence because fractions containing either O side chain or LPS of a heptoseless mutant were ineffective in provoking a hypersensitivity reaction. Conditions for the induction and the phases of development of this hypersensitivity to LPS and for anti-infectious resistance were shown to be different. Present and previously obtained results suggest that the antigens participating in each of these two conditions were different.
TL;DR: The significance of hapten and carrier specificity is discussed in terms of cooperating cells in the induction of delayed hypersensitivity in Rats actively immunized with p-azobenzenearsonate conjugates of polytyrosine, acetyltyrosines and acetyl-bovine serum albumin.
TL;DR: A case is described of a hypersensitivity reaction resulting from the administration of a dental local anaesthetic.
Abstract: A case is described of a hypersensitivity reaction resulting from the administration of a dental local anaesthetic.
TL;DR: It is not uncommon to initiate antibiotic therapy during the course of general anesthesia, particularly in contaminated or grossly infected patients, and antibiotics, acting as antigens, may initiate severe hypersensitivity reactions, including anaphylaxis.
Abstract: CUTE hypersensitivity reactions during A anesthesia are rare. Such reactions may be due to drugs other than the anesthetic agents.'-\" It is not uncommon to initiate antibiotic therapy during the course of general anesthesia, particularly in contaminated or grossly infected patients. Antibiotics, acting as antigens, may initiate severe hypersensitivity reactions, including anaphylaxis. Among antibiotics, penicillin has been by far the most common cause of such reactions.
TL;DR: In the following case, bilateral macular oedema occurred as a hypersensitivity reaction to densitizing pollen vaccine.
Abstract: Many diseases affecting the eyes are considered to be allergic manifestations (Cooke, 1947), but the retina and optic nerve are involved only rarely; retinitis, detachment of the retina, and optic neuritis may result (Tassmann, 1946). A contrary view is that retinal oedema was common during the era of serum therapy because of the high incidence of serum sickness. Foods, pollens, and drugs were also frequently incriminated (Boyd and Aaron, I963). In the following case, bilateral macular oedema occurred as a hypersensitivity reaction to densitizing pollen vaccine.
01 Jan 1971
TL;DR: It appeared that the immediate hypersensitivity observed and the subsequent transfer ofantibodies fromserum toudderexudate would provide a possible explanation of themechanisms ofimmunity tobovine vibriosis.
Abstract: Udderinfection ofvaccinated heifers withVibrio fetus var.venerealis ledtoan early andseverereaction consisting oflocal swelling, hyperthermia, andincreased blood leukocyte counts. Thisreaction was absent orless pronounced inheifers not previously vaccinated. This wasinterpreted asanimmediate hypersensitivity reaction elicited inthevaccinated heifers. Specific antibodies were foundinudderexudate fromvaccinated heifers. Immuneserum andudderexudate were moderately bactericidal andhada strong immunosuppressive andopsonophagocytic effect inrabbits. Immunecervicovaginal mucus was neither bactericidal nor opsonophagocytic orimmunosuppressive. Thiswouldsuggest thatantibodies foundincervicovaginal mucus arenotprotective. Itappeared that theimmediate hypersensitivity observed andthesubsequent transfer ofantibodies fromserum toudderexudate would providebyanalogy a possible explanation ofthemechanisms ofimmunity tobovine vibriosis.