Showing papers on "Liquid paraffin published in 1986"
TL;DR: Microencapsulation of ketoprofen using Eudragit RS, which is a copolymer synthesized from acrylic and methacrylic acid esters with a low content of quaternary ammonium groups, was investigated, and good reproducibility in microcapsule preparation was observed.
Abstract: Microencapsulation of ketoprofen using Eudragit RS, which is a copolymer synthesized from acrylic and methacrylic acid esters with a low content of quaternary ammonium groups, was investigated. The preparation is based on dispersion of acetone containing the drug in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility in microcapsule preparation was observed. The microcapsules obtained were uniform and free-flowing particles. The dissolution rates of ketoprofen from these microcapsules were considerably decreased as compared with that from ketoprofen powder.
75 citations
TL;DR: The results indicated that peritoneal macrophages and neutrophils have the highest capacity of phagocytosis.
Abstract: The morphology and phagocytic activity of peritoneal exudate cells (PEC) obtained by an intraperitoneal injection of liquid paraffin into tilapia, Oreochromis niloticus, and carp, Cyprinus carpio, were studied with light and electron microscopy. PEC consisted of monocyte-macrophage series cells (M-Mo), neutrophils, eosinophils (granular cells) and others. Cells exhibiting the same morphology as mammalian macrophages but different from monocytes of the same species were identified with light and electron microscopy and designated as peritoneal macrophages. Light and electron microscopy revealed that M-Mo, neutrophils and eosinophils (granular cells) phagocytozed foreign materials added in vivo and in vitro. Eosinophils appeared later in the peritoneal exudate and less actively phagocytic as compared with M-Mo and neutrophils. Small and large phagosomes were formed in M-Mo, neutrophils and eosinophils (granular cells). Large phagosomes were common in neutrophils. Fusion of cytoplasmic granules with the phagosome membrane was observed. The in vitro experiment on phagocytosis revealed that the phagocytic rates in M-Mo and neutrophils were positively correlated with the doses of foreign materials. The results indicated that these two cell types have the highest capacity of phagocytosis.
70 citations
TL;DR: Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated and it was presumed that aluminium tristearate reduces the phase tension between EUDragit microcapsules and liquid paraffin.
Abstract: Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated based on the dispersion system of ketoprofen-containing acetone in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility was observed in the microencapsulation and the resulting microcapsules were uniform, free-flowing particles. The phase diagram of ketoprofen-Eudragit RS or RL-aluminium tristearate indicated that it is only in a very limited region that spherical microcapsules ranging from 250 to 1000 microns in diameter could be prepared. Instrumental analysis using an energy dispersive-type X-ray microanalyser and a scanning electron microscope showed that aluminium tristearate was localized near the surface of the microcapsules. From these results, it was presumed that aluminium tristearate reduces the phase tension between Eudragit microcapsules and liquid paraffin. The dissolution patterns of ketoprofen from Eudragit RS and RL microcapsules were independent of the pH of the dissolution medium, and the dissolution rates were considerably lower than those from ketoprofen powders.
46 citations
TL;DR: The most important dermatologic problem of prolidase deficiency is chronic recurrent leg ulcers that are recalcitrant in healing and 5% glycine-5% proline ointment on leg ulcer with excellent results is used.
Abstract: To the Editor.— The most important dermatologic problem of prolidase deficiency1is chronic recurrent leg ulcers that are recalcitrant in healing. We used 5% glycine-5% proline ointment on leg ulcers with excellent results. Report of a Case.— The patient, now a 22-year-old woman, is the same patient as described previously.1She had never been free of recalcitrant leg ulcers despite various conventional therapies including topical application of antibiotics (gentamicin sulfate, colistin sulfate, polymyxin B sulfate, etc), leg bath in 0.01% potassium permanganate solution, oral administration of zinc sulfate (180 mg daily), and/or ascorbic acid (3 g daily). Oral L-proline (1 g daily) was also tried for two months with no apparent benefit. We decided to use topical proline and then a combination of topical proline and glycine on her leg ulcers. L-proline and/or L-glycine ground with a mortar and pestle was mixed in liquid paraffin (30 g) and
45 citations
TL;DR: From the phase diagram of ketoprofen-Eudragit E or S-aluminium tristearate, it became clear that the region in which the spherical microcapsules ranging from 250 to 1000 microns in size could be prepared was limited.
Abstract: Microencapsulation of ketoprofen using Eudragit E, L and S (acrylic resins) was investigated. The preparation is based on the dispersion of acetone containing ketoprofen in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. In the preparation of microcapsules, the reproducibility of the Eudragit E microcapsule was better than that of Eudragit L and S microcapsules. The microcapsules obtained were uniform and free-flowing particles. From the phase diagram of ketoprofen–Eudragit E or S–aluminium tristearate, it became clear that the region in which the spherical microcapsules ranging from 250 to 1000 μm in size could be prepared was limited. The dissolution patterns of ketoprofen from Eudragit E, L and S microcapsules were dependent on the pH of the dissolution medium.
24 citations
Patent•
05 Sep 1986TL;DR: A cream containing hydro-cortisone diester, which contains 0.01 - 0.5% of hydrocortisonesone, 1 - 10 % of beeswax, 1- 25 % of liquid paraffin, - 75 % of white petroleum jelly, 0 - 2 % of aluminium stearate, 2 - 20 % of W/O emulsifier based on straight-chain and branched hydrocarbons, glyceryl oleate and wool wax alcohols or poly-glyceryl-4 isostearate and hydrogen
Abstract: The invention relates to a cream containing hydro-cortisone diester, which contains 0.01 - 0.5% of hydrocortisone diester, 1 - 10 % of beeswax or beeswax substitute, 1 - 25 % of liquid paraffin, - 75 % of white petroleum jelly, 0 - 2 % of aluminium stearate, 2 - 20 % of W/O emulsifier based on straight-chain and branched hydrocarbons, glyceryl oleate and wool wax alcohols or poly-glyceryl-4 isostearate and hydrogenated castor oil, 0 - 2 % of hydrated magnesium sulphate and - 60 % of water.
22 citations
TL;DR: In this article, the rate constant for transfer of electronic energy from the first excited singlet state of the solvent toluene to two indoles, 1−p−chlorophenyl, 5−benzyloxy, 2−phenylindole and 5−methyl−3−phenylon, 1.propionitrile, as solutes in three types of solvent media was determined as a function of temperature in the range 293-353 K under oxygen-free conditions.
Abstract: The rate constant for transfer of electronic excitation energy from the first excited singlet state of the solvent toluene to two indoles, 1‐p‐chlorophenyl‐5‐benzyloxy‐2‐phenylindole and 5‐methyl‐3‐phenylindole‐1‐propionitrile, as solutes in three types of solvent media, pure toluene, 1:9 mixture of toluene and cyclohexane, and 1:9 mixture of toluene and liquid paraffin is determined as a function of temperature in the range 293–353 K under oxygen‐free conditions. The diffusion coefficients of the interacting molecules are measured in situ at ambient temperature. The rate constant is found to vary, in the case of each of the six systems, linearly with the sum of the diffusion coefficients of the two interacting molecules; from this linear variation the contributions of molecular diffusion and excitation energy migration to the rate constant are quantitatively estimated. The results indicate that energy migration involves weak multipole–multipole interaction between an excited and an unexcited solvent mole...
21 citations
TL;DR: In this article, the authors found that ephedrine (I) is delivered through human skin, in vitro, significantly faster from aqueous solutions of 3,4-dimethyl-5-phenyl-oxazolidine (II) with pH values between 7.0 and 10.88 than from corresponding solutions of I. The difference in penetration rates was most marked at pH7.0 where 917 μg and < 10 μg of I was delivered through 1.3 cm2 of skin in 24 h from 1% w/v solutions of II and I,
20 citations
TL;DR: Two North Sea crude oils, weathered crude oil, n-alkanes, medical liquid paraffin and a fish oil were microencapsulated and added to seawater to simulate the conditions in natural seawater contaminated with oil and give a medium containing both water soluble fractions and oil particles.
Abstract: Two North Sea crude oils, weathered crude oil, n-alkanes, medical liquid paraffin and a fish oil were microencapsulated and added to seawater. This gave a medium containing both water soluble fractions (WSF) and oil particles, and thus simulated the conditions in natural seawater contaminated with oil. The microencapsulated oils were fed to Mytilus edulis L. in different concentrations, and the growth in terms of shell length of the mussels was measured in intervals of 24 to 48 h for 4 to 12d. With the crude oilss A and B, weathered crude oil and n-alkanes at concentrations≧1 mg l-1, shell growth rate decreased rapidly compared to controls. With liquid paraffin at levels of 1 to 12 mg l-1, a small but significant negative effect on shell growth occurred after 5 d of exposure. Exposure to fish oil at 1 and 4 mg l-1 gave no significant reduction in growth rate. The toxicity of the different hydrocarbons was not related to their content of aromatic fractions. Crude oil B was tested at concentrations ranging from 0.12 to 12 mg l-1. At 0.12 mg l-1 shell growth was not significantly different from the control, while at 0.25 and 0.50 mg l-1 a temporary and significant stimulation of growth was observed. The product concentration (C)xresponse (R) shows a linear regression on exposure time (t). The regression model CxR=75-0.18t is used to estimate EC-values (effect of a given concentration) for given response levels. The model gives a very good fit to observed data.
18 citations
TL;DR: By using liquid paraffin and antifoam, both the epoxidation activity and the stability were improved, especially for the P‐1‐200 strain, over that for nonimmobilized cells, and N. corallina cells showed an apparent preference for a hydrophobic, as compared to a hydrophic, environment.
Abstract: Nocardia corallina B276 cells were immobilized by emulsification with liquid paraffin and an antifoam agent at room temperature. The immobilized cells were studied for their ability to carry out the formation of propylene oxide from propylene and oxygen. The evaluations were done with the cells in a bubble-type reactor with a continuous gas feed of 5% propylene and 11.6-95% oxygen, with the balance nitrogen. By using liquid paraffin and antifoam, both the epoxidation activity and the stability were improved, especially for the P-1-200 strain, over that for nonimmobilized cells. The N. corallina cells showed an apparent preference for a hydrophobic, as compared to a hydrophilic, environment. The propylene-oxide-forming activity of the immobilized cells was higher at 40 than at 30 degrees C reactor temperature and with 20% (versus 95%) oxygen in the feed. The stability was markedly better at 30 degrees C and with 20% oxygen. High gas flowrates gave increased apparent activity probably because of less resistance to substrate mass transfer. The effects of pH were minor. The role of glucose as the energy source for regeneration of cofactors for the monooxygenase system also is discussed.
14 citations
TL;DR: The unexpected availability of fatty acids bound to extrachloroplastidal lipids for incorporation into galactolipids characteristically assembled entirely within the chloroplast emphasizes the need to reassess interrelations between the "prokaryotic" and "eukaryotic".
Abstract: Long-chain 14C-fatty acids applied to the surface of expanding spinach leaves were incorporated into all major lipid classes. When applied in diethyleneglycol monomethyl ether solution, as done by previous workers, [14C]palmitic acid uptake was much lower than that of [14C] oleic acid. However, when applied in a thin film of liquid paraffin the rate of [14C] palmitic acid metabolism was rapid and virtually complete. Considerable radioactivity from [14C]palmitate incorporated into lipids following either application method gradually appeared in polyunsaturated C16 fatty acids esterified to those molecular species of galactolipids previously thought to be made using only fatty acids synthesized and retained within the chloroplast. Evidence for the incorporation of radioactivity from exogenous [14C]oleate into those same molecular species of galactolipids was less compelling. The unexpected availability of fatty acids bound to extrachloroplastidal lipids for incorporation into galactolipids characteristically assembled entirely within the chloroplast emphasizes the need to reassess interrelations between the “prokaryotic” and “eukaryotic” pathways of galactolipid formation.
Patent•
22 Apr 1986
TL;DR: In this paper, a method of impregnating a tissue specimen with paraffin either directly after an optional treatment of the tissue specimens with a fixing agent or after the tissue specimen optionally has been treated with either fixing agent and/or a dehydrating agent takes place.
Abstract: In a method of impregnating a tissue specimen with paraffin either directly after an optional treatment of the tissue specimen with a fixing agent or after the tissue specimen optionally has been treated with a fixing agent and/or a dehydrating agent an immersion of the tissue specimen into a bath of liquid paraffin takes place. The bath is kept below a predetermined temperature at which thermolabile components and properties of the tissue specimen undergo changes. The pressure of the bath is then lowered from atmospheric pressure to a predetermined pressure at which water present in the tissue specimen and/or, when appropriate, the dehydrating agent vaporizes, the pressure of the bath then being increased again to atmospheric pressure.
TL;DR: It is suggested from these preliminary experiments that C. albicans may be capable, in certain conditions, of causing further changes to hyperplastic epithelium resembling those seen in Candida leukoplakia.
Abstract: This investigation aimed to determine the effect of Candida albicans on hyperplastic epithelium. Epithelial hyperplasia was induced in hamster cheek pouches by painting the mucosa with 50% (v/v) turpentine and liquid paraffin (TLP50) for 10 weeks. The pouches were then tied off with sutures after inoculation with C. albicans. Many of the pouches lost their sutures and were histologically normal after periods up to 8 weeks. Those which remained tied off showed epithelial dysplasia resembling changes seen in human candida leukoplakia. It is suggested from these preliminary experiments that C. albicans may be capable, in certain conditions, of causing further changes to hyperplastic epithelium resembling those seen in Candida leukoplakia.
Patent•
22 Sep 1986
TL;DR: In this paper, a heat-curable liquid silicone rubber compsn. is dispersed in water at a temp. of not higher than 25°C to obtain a dispersion wherein the compsn is dispersed as a discontinuous phase in water.
Abstract: PURPOSE: To obtain particulate silicone rubber with good productibity, which has a uniform shape and excellent electrical insulating properties, by dispersing a heat-curable liquid silicone rubber compsn. in water at a specified temp. as a discontinuous phase and dispersing the dispersion in a liquid at a specified temp. to cure it. CONSTITUTION: A heat-curable liquid silicone rubber compsn. is dispersed in water at a temp. of not higher than 25°C to obtain a dispersion wherein the compsn. is dispersed as a discontinuous phase in water. The dispersion is dispersed in a liquid at a temp. of not lower than 50°C to cure the silicone rubber compsn. Examples of the liquid to be heated to 50°C or higher are water, liquid paraffin, wax, etc., among which water is particularly preferred. As the liquid silicone rubber compsn., those consisting of an organopolysiloxane (A) having at least two lower alkenyl groups per molecule, an organopolysiloxane (B) having at least two hydrogen atoms attached to a silicon atom per molecule and a platinum catalyst (C) are particularly preferred. COPYRIGHT: (C)1988,JPO&Japio
TL;DR: The effervescence that occurs when an insect is immersed in a mixture of liquid paraffin and butanol indicates that the waterproofing barrier may be very close to the surface, that this barrier varies greatly in permeability in different areas, and that it is readily permeable in the newly moulted insect, but becomes far more resistant as the cuticle hardens.
Abstract: The effervescence that occurs when an insect is immersed in a mixture of liquid paraffin and butanol indicates that the waterproofing barrier may be very close to the surface, that this barrier varies greatly in permeability in different areas, and that it is readily permeable in the newly moulted insect, but becomes far more resistant as the cuticle hardens. At the height of the effervescence the streams of expanding vesicles, that come from the surface, arise from fixed points—which suggests that the water is escaping from the terminations of the tubular filaments. It is shown that if the intact insect is warmed in a solution of ammoniacal silver at a succession of rising temperatures the argentaffin component of the extracuticular waterproofing layer is usually the first location of silver reduction, to be followed by the contents of the epicuticular channels piercing the outer epicuticle, the substance of the inner epicuticle, and the distal portions of the pore canals. The temperature at which this silver staining increases most rapidly parallels (approximately) the temperature at which transpiration in dry air begins to rise most steeply. It is inferred that both responses are probably dependent on the same temperature effects in the waterproofing lipids.
TL;DR: A method to microencapsulate water-soluble and liquid-paraffin insoluble drugs into spherical, discrete and free-flowing particles of approximately 175 microns size with excellent yield has been described taking diethylcarbamazine citrate as a model drug.
Abstract: A method to microencapsulate water-soluble and liquid-paraffin insoluble drugs into spherical, discrete and free-flowing particles of ±175 μm size with excellent yield has been described taking diethylcarbamazine citrate as a model drug. In this method a gelatin-drug dispersion at 50°C is sprayed, using a simple apparatus designed in our laboratory, into chilled, dry liquid paraffin present in a china dish previously coated with a layer of hard paraffin and maintained at 5°C. After allowing the droplets to gel at 5°C for an hour, water was removed by freeze drying. Later liquid paraffin adhering to freeze-dried microcapsules was removed by washing with chilled, dry acetone. Various factors affecting the yield, size, shape and size distribution of microcapsules were optimized.
TL;DR: In this article, gelatin microspheres of metronidazole, containing magnetite, with and without ethyloellulose costing have been prepared, based on dispersion of a gelating-nmetronide-magnetite-aueous suspension in liquid paraffin, followed by drying with isopropanol treatment.
Abstract: In this study gelatin microspheres of metronidazole, containing magnetite, with and without ethyloellulose costing have been prepared. The preparation is based on dispersion of a gelating-nmetronidazole-magnetite aueous suspension in liquid paraffin, followed by drying with isopropanol treatment. Coating of gelating microspheres with ethylcellulose was obtain by organic phase separation method. The magnetic responsiveness and the rheological properties of the microcapsule suspensions in physiological saline with 6% dextran, suggests that the microcapsules can be localized at a target site in vivo by meause of an externally applied magnetic field. The release of metronidazole from microspheres declined at an apparent first-order rate, but from ethylcellulose conted microcapsules followed an apparent zero-order rate. Gelatin microcapsules offer promise for attaining target site specificity.
Patent•
28 Aug 1986
TL;DR: In this paper, the objective of a film-forming cosmetic pack is a combination of a 1st agent composed of a clear gel produced by adding an oil such as squalane, liquid paraffin, etc., and a polyhydric alcohol such as glycerol, propylene glycol, etc.
Abstract: PURPOSE:To provide a safe film-forming cosmetic pack absolutely free from cosmetic pollution and consisting of a 1st agent composed of a clear gel of a polyglycerol fatty acid ester and a 2nd agent composed of an aqueous solution of a clear film-forming agent. CONSTITUTION:The objective film-forming cosmetic pack is a combination of (A) a 1st agent composed of a clear gel produced by adding an oil such as squalane, liquid paraffin, etc., and a polyhydric alcohol such as glycerol, propylene glycol, etc., to a polyglycerol fatty acid ester of formula (n is 0-15; R is acyl or H) (e.g. decaglycerol monostearate) and (B) a 2nd agent composed of an aqueous solution of a film-forming agent such as polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl monomer, etc. The cosmetic pack is used by applying the 1st agent to the surface of skin, applying the 2nd agent on the 1st agent, drying the agents and peeling the agents after a specific period. EFFECT:The agent gives improved moist feeling and can be peeled off from the skin without pain.
Patent•
05 Jun 1986
TL;DR: In this paper, the authors proposed a dry shampoo agent composition containing one or more oils selected from vegetable oil, animal oil and synthetic oil, a volatile oil (not especially limited, oil having ≤6hr volatilization time of 0.1g at 36.5°C measurement temperature and ≤30cs viscosity at 5°C, e.g. silicone oil, liquid paraffin oil, etc.).
Abstract: PURPOSE: The titled composition dissolving and removing stains on scalp and on the hair and further assisting healthy function of hair, containing an oil selected from vegetable oil, animal oil and synthetic oil, a volatile oil and a lower alcohol and having a viscosity in a specific range. CONSTITUTION: A dry shampoo agent composition containing one or more oils selected from vegetable oil, animal oil and synthetic oil, a volatile oil (not especially limited, oil having ≤6hr volatilization time of 0.1g at 36.5°C measurement temperature and ≤30cs viscosity at 5°C, e.g. silicone oil, liquid paraffin oil, etc.) and a lower alcohol (e.g. ethanol, etc.). The whole composition is adjusted to have ≤30cs viscosity at 5°C. The blending ratio of the components is 5W60, preferably 10W40wt% oil, 30W80wt%, preferably 40W70wt% volatile oil and 10W80wt%, preferably 15W80wt% lower alcohol based on the total amounts of the composition. COPYRIGHT: (C)1987,JPO&Japio
Patent•
11 Dec 1986
TL;DR: In this article, the objective is to provide the titled composition containing specific components such as an oil or fat, a wax, a hydrocarbon, a pigment, a film-forming polymeric compound and a microencapsulated liquid crystal compound, etc.
Abstract: PURPOSE:To provide the titled composition containing specific components such as an oil or fat, a wax, a hydrocarbon, a pigment, a film-forming polymeric compound and a microencapsulated liquid crystal compound, etc., at specific ratios, having a viscosity variable within a broad range, and giving a printed pattern coated with a coating film and resistant to peeling. CONSTITUTION:The objective composition is composed of 0.05-2(wt)% oil or fat (e.g. avocado oil), 0.05-3% wax (e.g. beeswax), 0.05-1% silicone, 0.06-5% hydrocarbon (e.g. liquid paraffin), 0.06-1.5% fatty acid (e.g. lauric acid), 0.04-3% oil-soluble alcohol (e.g. lauryl alcohol), 0.06-3.5% ester (e.g. isopropyl myristate), 0.04-6.2% surfactant, 0.16-6% glycol, 0.5-12% pigment (e.g. Red No.3), remaining part of water, 0.06-15% water-soluble polymeric compound (e.g. casein), 5.0-30.0% film-forming polymeric compound (e.g. acrylate copolymer) and 15-30% microencapsulated liquid crystal compound.
Patent•
12 Mar 1986
TL;DR: In this paper, a mixture of 1W50wt% white vaseline or liquid paraffin is blended with 2W20wt% higher alcohol, preferably cetanol or stearyl alcohol, and 0.5W10wt% nonionic surface active agent of ether type, having 10W20 HLB value, such as POE(20) cetyl ether, 50W80wt% water and urea.
Abstract: PURPOSE: A composition useful as a base for cream agent or a cream agent, having improved emulsion stability, feeling in use and endermic absorption characteristics of drug, obtained by blending a hydrocarbon with a higher alcohol, a nonionic surface active agent of ether type, water and urea. CONSTITUTION: (A) 1W50wt% hydrocarbon such as white vaseline or liquid paraffin is blended with (B) 2W20wt% higher alcohol, preferably cetanol or stearyl alcohol, (C) 0.5W10wt% nonionic surface active agent of ether type, preferably having 10W20 HLB value, such as POE(20) cetyl ether, (D) 50W80wt% water and (E) 1W30wt% urea. The urea blended has stability, especially heat stability, the composition is storable for a long period, rapidly varnishes owing to a large amount of water added and has either shining nor greasiness. The composition is useful as a cream agent for remedying skin diseases and also as a cream agent base for raising stability and endermic absorption properties of drug blended. COPYRIGHT: (C)1987,JPO&Japio
Patent•
26 Dec 1986
TL;DR: In this paper, a titled cosmetic is composed of 1.0-6wt% compound of formula (A is H or 12-18C acyl; n is 20-30), etc., 20-50% hydrogenated polybutene having an average molecular weight of 500-5,000, 2-15% maltitol (in terms of dry solid), 10-40% liquid oily substance (e.g., liquid paraffin, squalane, vegetable oil, etc.) and 2-30% water.
Abstract: PURPOSE:To obtain the titled cosmetic easily applicable to lip, giving moist feeling and excellent gloss to the lip and having excellent moisture-retaining effect, etc., by compounding a dextrin higher fatty acid ester, a hydrogenated polybutene, maltitol, liquid oily substance, water and, if necessary, a colorant. CONSTITUTION:The titled cosmetic is composed of 1.0-6wt% compound of formula (A is H or 12-18C acyl; n is 20-30), etc., 20-50% hydrogenated polybutene having an average molecular weight of 500-5,000, 2-15% maltitol (in terms of dry solid), 10-40% liquid oily substance (e.g. liquid paraffin, squalane, vegetable oil, etc.), 0-30% colorant (e.g. pigment, natural dye, etc.) and 2-30% water. The cosmetic is fluid creamy or pasty material having a viscosity of 10,000-100,000cps at 30 deg.C. Since the cosmetic has high adhesivity, it gives durable make-up resistant to spreading, gathering, movement, etc., and imparts emollient property to the lip to prevent the roughening of the lip.
Patent•
05 Aug 1986
Abstract: PURPOSE: To obtain a fine porous polyethylene membrane which is excellent in water permeability and has fine pore diameter suitable for the separation of a protein soln. or the like by using polyethylene having ultra-high molecular weight and constituting the fine porous membrane wherein the permeation velocity of pure water and the degree of inhibition for γ-globulin are specified value or more. CONSTITUTION: Polyethylene having weight average molecular weight not less than 5 × 10 5 is dissolved in a solvent such as liquid paraffin by heating and an antioxidant is added thereto and the obtained soln. is introduced into a heated die and quenched to mold a gel-like sheet. This sheet is immersed into methylene chloride or the like and liquid paraffin is extracted and removed to perform the treatment for removing the solvent and a raw fabric sheet wherein the amount of the solvent incorporated in the gel-like sheet is regulated to 80W95 wt% is obtained. After subjecting this sheet to simultaneous biaxial stretching by a biaxial stretching machine at 120°C or less under the conditions of not less than 2 times in the uniaxial direction of area magnification not less than 10 times, it is washed with methylene chloride or the like to extract and remove the residual liquid paraffin and dried and a fine porous memberane having permeation velocity of pure water not less than 100 l/m 2 .hr.atm and the degree of inhibition for γ-globulin not less than 50% is obtained. COPYRIGHT: (C)1988,JPO&Japio
Patent•
31 Jul 1986
TL;DR: In this article, a cyclodextrin (CD)-clathrate compound is added to a liquid oil (or heated oil which is solid at normal temperature) and dispersed by mixing to effect the coating of the oil to the CD.
Abstract: PURPOSE:To obtain a clathrate compound capable of controlling the volatility of perfumery and stably keeping the perfumery in any storage state, by coating a clathrate compound of a perfumery and cyclodextrin (CD) with an oil. CONSTITUTION:1pt.(wt.) of CD is thoroughly kneaded with 0.5-5pts. of water and the produced paste is further kneaded together with a perfumery to effect the inclusion of the perfumery. The obtained paste is dried and finely pulverized with a crusher. The resultant CD clathrate compound is added to a liquid oil (or heated oil which is solid at normal temperature) and dispersed by mixing to effect the coating of the oil to the clathrate compound. The oil is preferably a nonpolar liquid (e.g. liquid paraffin, squalane, etc.) and the weight ratio of the oil to the clathrate compound is 10:1-1:100. The coated CD-clathrate compound is preferably added at an amount of about 1-10% based on the whole cosmetic.
Patent•
03 Apr 1986
TL;DR: In this article, the surface of a solid powdery cosmetic is covered with a press sheet impregnated or coated with a releasant, which can be used to obtain a mold-releasability and beautifully finished surface appearance.
Abstract: PURPOSE: To obtain a solid powdery cosmetic having excellent mold-releasability and beautifully finished surface appearance, by inserting a releasant-containing press sheet between a press head and a solid powdery cosmetic in the press forming of the cosmetic. CONSTITUTION: A definite amount of a solid powdery cosmetic is put into an intermediate dish fixed to a mounting table and the surface of the cosmetic is covered with a press sheet impregnated or coated with a releasant. A formed solid powdery cosmetic can be produced by pressing the cosmetic with a press head in a state providing the press sheet between the press head and the solid powdery cosmetic. The releasant is selected from an oleophilic surfactant of ≤5 HLB (e.g. sorbitan monooleate), a hydrocarbon which is liquid at normal temperature (e.g. liquid paraffin), a volatile silicone (e.g. methylpolysiloxane), an oleophilic surfactant having an HLB of ≥10 [e.g. POE(7.5)-nonyl phenyl ether] and a polyhydric alcohol (e.g. glycerol). COPYRIGHT: (C)1987,JPO&Japio
Patent•
24 Dec 1986
TL;DR: In this paper, a straight chain low-density polyethylene with a melt index determined by the procedure ASTM-D-1238(E) <40 (pref. 10W30) is kneaded with 0.1W50wt% based on the component A, of (i) low-molecular weight polyethylenes with a melting index determined with ASTM D-12 38(E), ≥40 and/or (ii) liquid paraffin using e.g. an extruder followed by extrusion and cutting into pellets.
Abstract: PURPOSE: To obtain the titled fiber suitable for nonwoven fabrics for use in diaper covers and sanitary goods, by blending specified amount of low molecular weight polyethylene and/or liquid paraffin with specific straight chain low- density polyethylene followed by melt spinning. CONSTITUTION: (A) Straight chain low-density polyethylene with a melt index determined by the procedure ASTM-D-1238(E) <40 (pref. 10W30) is kneaded with (B) 0.1W50wt% based on the component A, of (i) low-molecular weight polyethylene with a melt index determined by the procedure ASTM-D-1238(E) ≥40 and/or (ii) liquid paraffin using e.g. an extruder followed by extrusion and cutting into pellets. This pelletized polymer is then brought to melt spinning at 180W230°C to obtain the objective fiber. COPYRIGHT: (C)1988,JPO&Japio
Patent•
16 Apr 1986
TL;DR: In this paper, the authors presented a tile joint compound composition, containing a cation exchange substance holding metal ions with germicidal action, having improved antimicrobial ability against general bacteria, capable of sustaining effect for a long period and useful as a tile compound.
Abstract: PURPOSE: The titled composition, containing a cation exchange substance holding metal ions with germicidal action, having improved antimicrobial ability against general bacteria, capable of sustaining effect for a long period and useful as a tile joint compound, etc. CONSTITUTION: A composition obtained by treating a cation exchange substance holding metal ions having germicidal action, e.g. silver, etc., preferably with a coating agent and blending 0.05W20wt% resultant substance in a joint compound composition. Liquid paraffin, etc., is preferably used as the above- mentioned agent and an organic cation exchanger, e.g. powdery (granular) strong (weak) acid type cation exchanger, etc., or inorganic cation exchanger, e.g. powdery (granular) zeolite, etc., having ≥1meq/g ion exchange capacity is preferably used as the cation exchange substance. COPYRIGHT: (C)1987,JPO&Japio
Patent•
10 Feb 1986
TL;DR: A polishing agent consisting of polyurethane emulsion, water and additives is used to make the leather highly glossy, water-resistant and of good weatherability as mentioned in this paper.
Abstract: A polishing agent comprises polyurethane emulsion, water and additives. It is strongly adhesive and dries fast. It is not poisonous, and odourless. Its use makes the leather highly glossy, water-resistant and of good weatherability. It is of low cost and good stability. When certain amounts of pigment paste and emulsified paraffin or liquid paraffin is added, it may be directly used as leather protective agent
12 Jan 1986-Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health
TL;DR: In a field trial with 5,000 sheep the vaccine gave protection against anthrax for two years as judged by the absence of the disease in any sheep during that time, no side effects or local reactions were seen at the site of injection.
Abstract: Summary
Lanolin and liquid paraffin were used to make a new oil adjuvant anthrax vaccine, by using the well-known non-capsulated and avirulent anthrax strain 34F2.
Eighteen mice, 30 guinea-pigs, and 48 sheep were used in the experiment. The mice and guinea-pigs were challenged with Pasteur strain II (JB17) and the sheep with a local virulent anthrax strain (Basrah). Most of the mice and guinea-pigs resisted challenge 21 days after vaccination and all the sheep in the experiment resisted the challenge. In a field trial with 5,000 sheep the vaccine gave protection against anthrax for two years as judged by the absence of the disease in any sheep during that time. No side effects or local reactions were seen at the site of injection. The vaccine also proved to be as practical to use in the open.
Zusammenfassung
Immunisierende Eigenschaften einer attenuierten “Sporenvaccine” mit Oladjuvans gegen Milzbrandinfektionen beim Schaf
Mit Lanolin und flussigem Paraffin wurde eine neue Oladjuvansvaccine gegen Milzbrand entwickelt. Als Impfstamm diente der bekannte kapsellose, avirulente Milzbrandstamm “34F2”.
Die experimentellen Untersuchungen wurden bei 18 Mausen, 30 Meerschweinchen und 48 Schafen durchgefuhrt. Die Testinfektion erfolgte bei Mausen und Meerschweinchen mit dem Pasteurstamm II (JB17) und bei Schafen mit dem virulenten Milzbrandstamm “Basrah”. Nach einmaliger subkutaner Impfung waren die meisten Mause und Meerschweinchen sowie alle Schafe gegen eine experimentelle Milzbrandinfektion (21 Tage p. vacc.) geschutzt. Bei 5000 in der Praxis geimpften Schafen traten innerhalb von 2 Jahren nach der Impfung keine Milzbrandinfektionen mehr auf. Nebenwirkungen oder lokale Impfreaktionen wurden nicht beobachtet. Die neue Milzbrandvaccine wird fur den allgemeinen Gebrauch empfohlen.
Patent•
14 May 1986
TL;DR: In this article, a rotary disc is used to scatter the mixture supplied from a mixture supply device by centrifugal force and a receiving tank is provided below the disc to receive the beads of the mixture and storing a solution for gelling said beads.
Abstract: PURPOSE:To prepare a large amount of a capsule within a short time, by a method wherein beads of a mixture of a substance to be encapsulated such as enzyme supplied continuously and a sol-like substance are scattered from the outer periphery of a disc by the centrifugal force generated on the disc to be allowed to fall in a gelling solution. CONSTITUTION:A mixture supply device 1 for continuously supplying a mixture of a substance encapsulated such as enzyme, a seed or adventive embryo and a sol like substance such as sodium alginate, carboxy methyl cellulose or agar is provided to a capsule manufacturing apparatus M. Further, a rotary disc 2 for scattering the mixture supplied from the apparatus 1 by centrifugal force and a receiving tank 3 provided below said disc 2 to receive the beads of the mixture scattered from the disc and storing a solution for gelling said beads are arranged to the apparatus M. A complexing agent, a crosslinking agent and liquid paraffin regulated in temp. are stored in the receiving tank 3 corresponding to the sol-like substance.