Showing papers in "International Journal of Pharmaceutics in 1986"

TL;DR: In this article, a Kepner-Tregoe decision analysis approach was used to provide rationale to salt selection for basic drugs, where the selection objectives were reviewed in terms of the "MustS" and "Desirable" issues.

TL;DR: In this article, human skin permeation of naloxone was examined in vitro using various vehicles and penetration enhancers, and the maximum flux was with C 12 adjuvants, and for C 18 acids and alcohols unsaturated adjvants were more effective than saturated ones.

TL;DR: In this paper, conditions for condensation of β-cyclodextrin with propylene oxide were found which give preparations of hydroxypropyl-β-cyclodextrin with a narrow and symmetrical distribution of the degree of substitution.

TL;DR: In this paper, the dispersion of an alcoholic solution of isobutylcyanoacrylate and oil in water, by interfacial polymerization, allows the formation of nanocapsules with an average diameter of about 200-300 nm.

TL;DR: The importance of lipid solubility in a vehicle such as peanut oil (as well as partition coefficient) as an important criteriom for estimating the potential for intestinal lymphatic transport of orally ingested drugs and xenobiotics is focused on.

TL;DR: Low toxicity, reverse thermal gelation and high drug loading capabilities, suggest that PF-127 gels have great potential as a drug delivery system.

TL;DR: Poly(lactic acid) microspheres of 1–10 μm diameter prepared by emulsion deposition and containing entrapped prednisolone released the drug rapidly into an aqueous medium and may have potential as a long-acting parenteral delivery system.

TL;DR: The powerful dysopsonic and anti-adhesive properties of poloxamer 338 were attributed to the large anchoring hydrophobic group preventing displacement of the polymer from the particle surface by plasma proteins and the two identical hydrophilic groups preventing cell adhesion and subsequent phagocytosis (steric stabilization).

TL;DR: In this article, the degradation kinetics of doxorubicin in aqueous solution were investigated utilizing a stability-indicating HPLC assay with UV-VIS and fluorescence detection.

TL;DR: A novel method is presented to evaluate diffusion-controlled release of a drug from a resinate that is direct, simple, involves no trial and error, and is applicable to any drug-resin complex.

TL;DR: Iontophoresis may be a convenient means by which to achieve constant and readily controllable transdermal delivery, locally or to the systemic circulation, for ionized drug species (including peptides).

TL;DR: It is suggested that, before guidelines can be established to select a given route for optimal peptide delivery, further work is necessary to determine if the non-oral routes differ in non-aminopeptidase activity and in membrane permeability.

TL;DR: Investigation of the effectiveness of a dosage form approach for monitoring both the inactivation and the absorption processes by targeting insulin delivery to the colon found that the preadministration of a surfactant capsule did not change the glycemic profile; however, its post-administration prolonged the effect of RS2 by one hour.

TL;DR: The intranasal absorption of gentamicin in rabbits was related to the hydrophobicity and the pK a 's of the bile salts, and the effects on ciliated epithelium of the six biles salts, used in the absorption experiment, were studied in an in vitro model.

TL;DR: In this paper, the solvent evaporation process has been used to form progesterone-loaded microspheres from poly( d,l -lactide). Methylene chloride was the casting solvent.

TL;DR: In this paper, the effects of β-cyclodextrin (β-CD) and di-O-methyl-β-cyclodextrin (DM-β -CD) on percutaneous absorption of butylparaben (BP), indomethacin (IM), and sulfanilic acid (SA) were investigated.

TL;DR: In this paper, the characteristics of incorporation and adsorption of drugs onto poly(butyl 2-cyanoacrylate) nanoparticles have been studied using two model compounds, rose bengal and adriamycin.

TL;DR: In this article, phase solubility studies revealed a 12-fold increase in the Solubility of ibuprofen and the formation of an insoluble microcrystalline complex in the presence of high concentration of β-cyclodextrin (β-CD).

TL;DR: In this paper, the effect of the molecular weight of cellulose on the drug release properties of mixed films of ethyl cellulose and hydroxypropyl methylcellulose has been studied by coating spherical granules with a film and measuring the release of a water-soluble model drug substance.

TL;DR: Peanut oil was the least effective lipid vehicle with respect to the lymphatic transport of DDT, and there was no significant difference in the cumulative transport ofDDT within a particular lipid class (triglyceride, fatty acid or oleic acid-monoolein).

TL;DR: The plasticizing efficiency of polyethylene glycols when added to both ethyl cellulose and hydroxypropyl methylcellulose films has been evaluated by measuring the glass transition temperatures of formulations using the torsional braid pendulum as discussed by the authors.

TL;DR: Several models have been investigated for their appropriateness in describing the release of adriamycin from heat-stabilized bovine serum albumin microspheres and bi-exponential first-order, bi-phasic zero-order and Higuchi's square-root of time equations are investigated.

TL;DR: It is proposed that co-administered oil initially protects cefoxitin from acid degradation in the stomach and that digestion of medium chain triglyceride liberates fatty acids that have a transient effect on membrane fluidity and allow increased absorption.

TL;DR: Poly(butyl 2-cyanoacrylate) nanoparticles were radiolabelled with a technetium-99m-dextran complex and the biodistribution pattern of the intravenously injected particles determined in rabbits using γ-scintigraphy, and found to localise partly in the liver/spleen region and stay in the circulation before degrading and releasing the radiolabel.

TL;DR: In this article, the effects of polyvinylpyrrolidone, gelatin and methylcellulose binding agents on the tableting properties of a metronidazole-lactose-starch formulation and on the tensile strengths (T) of tablets produced from both granular and powdered forms of the formulation were made.

TL;DR: In this article, the effect of pH, buffer concentration and temperature on the decomposition of erythromycin A in aqueous solution was investigated and the mechanistic implications of these observations were discussed.

TL;DR: In this paper, the authors calculated the effective surface area and boundary layer thickness of pharmaceutical powders in 2-propanol/water mixtures by taking the corresponding solubilities and diffusion coefficients into account.

TL;DR: Azone and PG both enhanced membrane permeability relative to water and acted synergistically on the penetration of the antiviral compound, while PEG-300 appeared to be less efficient than water as a vehicle.

TL;DR: The FISDD technique could be used either to reveal or explore food-drug and/or food-formulation interactions anticipated or observed in vivo, and the potential significance with respect to the in vitro study of dissolution of drugs in food simulating media is discussed.