Showing papers on "Major Salivary Gland published in 1981"

Tumors of the Major Salivary Glands

Abstract: One-hundred and eight cases of major salivary gland tumors and allied conditions treated in the Department of Otolaryngology, Mie University Hospital were reviewed according to the classification of the World Health Organization (WHO) and analyzed in terms of mode of presentation, diagnostic technique, treatment and end results.It was shown that the commonly involved salivary gland was the parotid gland and the most prevalent tumor was pleomorphic adenoma. Of the 108 cases, 81 were parotid tumor cases, and the ratio of benign to malignant tumors was 2.37:1. The remaining cases were tumors of submandibular and sublingual gland origin, and the ratio of benign to malignant was 1.71:1.We have principally performed enucleation surgery for all the benign parotid tumors, except six cases in which either superficial lobectomy or total lobectomy was performed. For malignant parotid tumors, enucleation surgery was performed in 9 cases, superficial lobectomy in two cases and total lobectomy in 10 cases. Of the above 21 cases, irradiation was added in 4 cases, combination therapy of irradiation and chemotherapy was administered in 11 cases. For all the cases of the tumor of the submandibular gland or sublingual gland, total extirpation of the gland with the tumor was performed.In accordance with the proposal of the American Joint Committee for Cancer Staging and End Results Reporting (1975), staging of 17 cases with malignant parotid tumors, which were followed more than one year, was determined. The five-year survival rate according to the stage was found to be 100% for T1N0M0, 75% for T2N0M0, 0% for T3N0M0, 0% for T3N1M0 and 0% for T3N1M1.The literature on new diagnostic procedures, treatment and prognosis was reviewed.

Monomorphic adenomas of major salivary glands: a histologic study of 96 tumours*

Abstract: It has been a little over a decade since monomorphic adenomas were formally recognized as a class of salivary gland tumours separable from the more common pleomorphic adenomas. This short time and a relatively low incidence, estimate at less that 2% of all salivary gland tumours, have not allowed histopathologic review of any sizable number of the tumours. The present study of 102 monomorphic adenomas; 96 in major salivary glands, establishes the histologic heterogeneity of the tumours and permits a classification based on this histologic variation as well as differences in histogenesis. For a number of the tumours, a hamartomatous deviation from stages in the normal organogenesis of salivary glands is strongly suggested. An analogous relationship exists for adenexae of the skin and their tumours. Identification of 12 tumours bearing a striking resemblance to dermal eccrine cylindromas carries the analogy further. Given the acceptance of the classification and time, a correlation of the subtypes of monomorphic adenoma with biological behaviour should follow.

Dermal analogue tumours of major salivary glands.

Abstract: Monomorphic adenomas of the major salivary glands manifest a histologic spectrum whose diversity rivals that of pleomorphic adenomas. In nearly all forms of monomorphic adenomas there are histologic features which recall stages in the embryonic development of salivary glands and/or adenexae of skin. A close histogenetic relationship between certain monomorphic adenomas and certain adenexal tumours of skin is suggested by the findings of this report. Within the diversity of expression found in monomorphic adenomas are subsets of tumours which are analogous and nearly homologous with dermal appendage tumours, especially the dermal eccrine cylindroma. The analogous relationship is carried further by a proposed diathesis in which patients exhibit histologically similar tumours in their salivary glands and skin.

Aspiration biopsy cytology of the salivary gland.

Abstract: Aspiration biopsy by fine needle from the major salivary glands has been an under-utilized technic in the United States. To evaluate this form of biopsy, 69 patients with salivary gland enlargement were examined by this technic; 47 had confirmative histology. Characteristic ABC patterns were seen in the benign mixed tumor, the papillary cystadenoma lymphomatosum, the mucoepidermoid carcinoma, and malignancy metastatic to the salivary gland. These findings are described. The method proved complication-free and accurate and is recommended for all tumors of the salivary gland.

The incidence of neoplastic versus inflammatory disease in major salivary gland masses diagnosed by surgery.

Abstract: What is the incidence of non-neoplastic diseases when dealing with masses of the major salivary glands? A knowledge of this information would aid the physician in making decisions relative to the management of the masses. Furthermore, the expected malignancy rate may need to be adjusted according to the findings of this study. Many reported series of salivary gland neoplasms show the relative incidence of benign vs. malignant neoplasms; however, not every patient with a mass of the salivary gland who comes to surgery is finally diagnosed as having had a neoplasm. Knowing the relative incidence of neoplastic vs. non-neoplastic salivary gland diseases has important diagnostic, therapeutic, and prognostic implications. Records of all patients who underwent either a parotidectomy or submandibular gland excision from 1975 to the present at the Eye and Ear Hospital of Pittsburgh were reviewed; 73% of the parotidectomies performed were done for neoplastic disease. A patient with a parotid mass has a likelihood of 1:10 of having a malignancy. Similarly, on a population basis, 1 submandibular mass in 12 will be malignant.

Basal cell adenoma of the major salivary glands. Report of a case with facial nerve encroachment.

Abstract: Basal cell adenoma of the parotid gland showed histopathologic evidence of facial nerve encroachment. A review of the pertinent literature and a discussion of current concepts of histogenesis of the tumor indicate that a spectrum of benign to malignant forms of this unusual tumor may exist. The sparsely reported association of this tumor and its malignant variants to facial nerve pathology is discussed, and recommendations for treatment are made.

Malignant neoplasms of the major salivary glands

Abstract: Between January 1, 1968 and December 31, 1978, 42 patients with malignant lesions involving the major salivary glands were seen at the Medical College of Virginia. A 60% 2-year survival and a 42% 5-year survival were noted. Histologic type was the major determinant of survival. Symptoms other than a painless mass, a largest dimension greater than 4 cm, older age, and clinical spread outside the gland were all suggestive of both a more malignant histologic type and a worse prognosis. Based on these observations, a plan is proposed for the diagnostic approach and treatment of salivary gland masses that is based on the mode of presentation and histologic findings.

Non-neoplastic disorders of the parotid gland.

Abstract: The parotid glands are subject to many pathological disorders other than neoplastic diseases. This large group of disorders is classified for the parotid glands into infectious, metabolic and endocrine, traumatic, congenital, and acquired cystic diseases. The other major salivary glands also can be affected by many of these conditions. In recent years more and more patients have been examined and treated who have had diseases classified according to our concepts. Surgical procedures are now commonly recommended for these groups of patients not only for diagnosis but for treatment as well. The microscopic examination of permanently prepared, stained excised tissues still remains the final diagnostic procedure in most patients in spite of more recently developed diagnostic techniques. Further, the well trained surgeon of today is in a position to assure the patient that permanent injury to the facial nerve trunk or to its branches is only a remote possibility. Lastly, our medical and surgical experiences are discussed in the following groups of patients: those with acute suppurative sialadenitis, those with acute abscess, those with chronic obstructive and non-obstructive sialadenitis, those with traumatic lesions, those with congenital lesions, and those with acquired cystic lesions.

[Elimination of major salivary glands by temporary medicamentous occlusion of the excretory ducts (author's transl)].

Abstract: The treatment of chronic recurrent inflammation of major salivary glands means reduction or elimination of parenchyma. Several operative and non-operative procedures have been described for this purpose. A new method is the instillation of an amino-acid solution which is hardening in the excretory ducts. Histological findings in experiments on animals show an atrophy of parenchyma while the filling mass is completely removed. Some patients were treated successfully by this method up to now.

CHARACTERISTICS OF SALIVARY α-AMYLASE OF THE MOUSE

Abstract: Publisher Summary This chapter describes the characteristics of salivary alpha-amylase of the mouse. This enzyme is involved in the hydrolysis of complex carbohydrates. It is derived from the major salivary glands and is present in saliva in high concentrations. Murine salivary amylase is predominantly localized in the parotid glands (Par), whereas a minor fraction is present in the submandibular (SM) and sublingual (SL) glands. This chapter presents a study in which this enzyme was isolated and compared with Par-amylase by biochemical, immunochemical, and immune histochemical techniques. In addition, different types of SM secretory granules were isolated and identified by their protein composition. The native SM-amylase appeared to be immunochemically nonidentical to Par-amylase, and the localization of SM-amylase was apparently dependent on the method applied. In a few studies, various types of secretory granules were isolated and studied by electron microscopy and by biochemical and immunochemical methods.