Showing papers on "Meth- published in 1988"
TL;DR: The METH-induced changes appeared to be mediated by dopamine released from the nigral-striatal dopamine projection, and administration of the METH analog, 3,4-methylenedioxymethamphetamine, appeared to alter striatal and nigral DLI concentrations in a manner similar to that of METH.
75 citations
TL;DR: Results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumours mechanisms by this streptococcal preparation is the induction of TNF.
Abstract: The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type Meth A fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of Meth A. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on Meth A cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.
39 citations
TL;DR: Analysis of the nucleotide sequence of the metH promoter region showed that two sequence elements are not present in the promoters of all other met biosynthetic genes thus far examined, namely, the repeated MetJ repressor recognition sequence 5'-AGACGTCT-3' and a highly conserved sequence 5'TGGA----TAAAC-3', of unknown function.
29 citations
TL;DR: Investigation of the expression of the chromosomal- and plasmid-encoded gene products confirms that metE is subject to negative control by vitamin B12 and methionine, and that metH is under positive control by the cofactor and negative control as an oligomer.
Abstract: We have cloned the genes for the two homocysteine transmethylases of Escherichia coli K12. The vitamin B12-independent enzyme is encoded by the metE gene while the metH gene codes for the vitamin B12-requiring enzyme. Overexpression of the gene products and Tn1000 mutagenesis have enabled the metE and metH gene products to be identified as 99 kDa and 130 kDa polypeptides, respectively. The truncated polypeptides generated by Tn1000 insertion were used to determine the direction of transcription of the metE and metH genes. Negative complementation suggests that the MetH enzyme exists as an oligomer. Investigation of the expression of the chromosomal- and plasmid-encoded gene products confirms that metE is subject to negative control by vitamin B12 and methionine, and that metH is under positive control by the cofactor and negative control by methionine. For vitamin B12 and methionine to act as regulatory effectors in metE control, functional metH and metJ genes are required, respectively. The use of stable Tn1000-generated fragments of the metE product as electrophoretic markers for the plasmid-encoded metE gene product demonstrated that the two regulatory proteins involved in negative control of metE are present in excess. Under conditions whereby both forms of negative metE control are non-functional, the metE gene product represented about 90% of the total protein, and cell growth was severely impaired.
25 citations
TL;DR: The previous and present results suggest that A. capillaris shows antitumor activity mainly through a direct cytotoxicity, although this herb might have certain components to enhance Meth A-DTH, and the other herbs display the activity through the enhancement of T cell-mediated tumor immunity, particularly tumor specific DTH.
18 citations
Patent•
08 Mar 1988
TL;DR: In this article, the title composition is composed of 40-100% of a urethane poly(meth) acrylate, obtained by reaction between tolylene diisocyanate, a compound bearing at least one of hydroxyl and at least 1 of (meth)-acryloyloxy group in one molecule such as 2-hydroxyethyl (methyl acrylated, and 0-60wt% of polyvalent (mETH) acylate copolymerizable with component A such as polyol poly poly(
Abstract: PURPOSE:To obtain the title composition which is used as a primer for vacuum metallization of plastic moldings, by using, as main components, a specific urethane poly(meth)acrylate and polyvalent (meth)acrylate copolymerizable therewith CONSTITUTION:The objective composition is composed of (A) 40-100wt% of a urethane poly(meth)acrylate, obtained by reaction between tolylene diisocyanate, a compound bearing at least one of hydroxyl and at least one of (meth)-acryloyloxy group in one molecule such as 2-hydroxyethyl (meth) acrylate, (B) 0-60wt% of a polyvalent (meth)acrylate copolymerizable with component A such as polyol poly(meth)acrylate, (C) a photopolymerization initiator and (D) a fluorine surfactant cs
6 citations
TL;DR: Injection of [3H]-METH near the 14-day-old embryo, followed by differential extraction, indicated that significant quantities of unmetabolized METH gained entrance to the brain, peaking at about 1 hr and declining with a half-life of about 2.8 hr.
Abstract: Unlike N-desmethyl-1-alpha-acetylmethadol (NLAAM), a single injection of methadone (METH), near domestic chicken embryos early during development, cannot induce and sustain opioid-type dependence in the older embryo (i.e., days 14-17 of development). Injection of [3H]-METH near the 14-day-old embryo, followed by differential extraction, indicated that significant quantities of unmetabolized METH gained entrance to the brain, peaking at about 1 hr and declining with a half-life of about 2.8 hr. Thus, it is probably not practical to use a single injection of this shorter-acting opioid for studying biobehavioral effects of sustained dependence and withdrawal during development in this species. Chronic infusion of METH for 7 days via an externalized Alza osmotic mini-pump resulted in significant, dose-dependent brain concentrations of [3H]-METH on day 14. Even though the opioid antagonist naloxone (Nx) was unable to induce withdrawal, manifest as a significant increase in embryonic motility above that of controls, it partially reversed the depressed motility caused by the chronic infusion of [3H]-METH. Since 7-day-old embryos exposed to NLAAM, at doses which can be demonstrated to produce dependence by precipitating withdrawal on day 17 of development, were also unable to express withdrawal on day 14, it is possible that either 14-day-old chicken embryos cannot yet fully respond with an adaptive process (i.e., dependence) or its expression (i.e., withdrawal).
6 citations
Patent•
14 Nov 1988
TL;DR: In this article, the molar ratio of the tetrahydrobenzyl alcohol to the (meth)acrylic acid in the esterification reaction is 1/10-10/1, preferably 1/1-1/3.
Abstract: NEW MATERIAL:The compound of formula (R is H or methyl). USE:Useful as a raw material or modifier for ink, paint, adhesive, coating agent or molding resin. It has low viscosity and odor and is soluble in a wide variety of resins. PREPARATION:The compound of formula can be produced by reacting tetrahydrobenzyl alcohol with (meth)acrylic acid or a (meth)acrylic acid ester in the presence of a catalyst (e.g. p-toluenesulfonic acid) and a polymerization inhibitor (e.g. hydroquinone) in a solvent (e.g. n-hexane) at 60-150 deg.C. The molar ratio of the tetrahydrobenzyl alcohol to the (meth)acrylic acid in the esterification reaction is 1/10-10/1, preferably 1/1-1/3. The amount of the catalyst is preferably 0.01-1.0wt.% based on the starting raw material and that of the polymerization inhibitor is preferably 0.01-1.0wt.% based on the (meth)acrylic acid.
5 citations
TL;DR: In vitro, ascorbic acid increased significantly DA-mediated [3H]5-HT release from striatal slices, thus suggesting a potential role for asCorbate in DA- mediated actions of METH on serotonergic systems.
5 citations
Patent•
18 Nov 1988TL;DR: New di(meth)acrylates of the formula (I) in which R is hydrogen or methyl and n is the number 1 or 2 were proposed in this article.
Abstract: New di(meth)acrylates of the formula (I) in which R is hydrogen or methyl and n is the number 1 or 2.
4 citations
Patent•
16 Feb 1988
TL;DR: In this paper, a (meth)acryloyl derivative of N-substituted L, D or DL proline of formula I (X is H or CH 3 ; R 1 is R 1 or C n H 2n+1 ) is polymerized using a catalyst or radiation.
Abstract: PURPOSE: To obtain the title polymer, having responsive function to stimulations, useful as a gel sensor or a thermosensor, by polymerizing a (meth)acryloyl derivative of proline using a catalyst or radiation. CONSTITUTION: A (meth)acryloyl derivative of N-substituted L, D or DL proline of formula I (X is H or CH 3 ; R 1 is H or C n H 2n+1 ) is polymerized using a catalyst or radiation, thus obtaining the objective polymer. Alternatively, a polymerizable monomer with an active functional group such as N-(meth)acryloxysuccinimide, 1-(meth)acryloxybenzotriazol or p-(meth)acryloxynitrobenzene is chemically combined with L, D or DL proline or a derivative thereof and the resultant compound is subsequently polymerized using a catalyst or radiation. COPYRIGHT: (C)1989,JPO&Japio
Patent•
23 Jul 1988
Patent•
02 Apr 1988
TL;DR: In this article, a radical polymerization initiator is added to a vapor phase containing vapor of a (meth) acrylate monomer (e.g., methyl methacrylate).
Abstract: PURPOSE:To obtain the title ultrahihg-MW structure copolymer excellent in heat resistance and strength, low in the temperature dependency of refractive index and suitable as an optical material, by copolymerizing a (meth)acrylate with a fluorinated (meth)acrylate by a specified polymerization process. CONSTITUTION:A radical polymerization initiator (e.g., benzoyl peroxide) is added to a vapor phase containing vapor of a (meth)acrylate monomer (e.g., methyl methacrylate) and vapor of a fluorinated (meth)acrylate monomer (e.g., monofluoromethyl methacrylate), and this vapor phase is irradiated with plasma. The generated polymerization-initiating active species are led to a monomer coagulation phase, where the chain-growth polymerization of the monomer is performed. In this way, the purpose ultrahigh-MW structure copolymer of an intrinsic viscosity of 1X10 4X10 can be obtained. This copolymer can be suitably used as an optical material for a waveguide.
Journal Article•
TL;DR: It is found that these two commonly abused stimulants significantly interact and a 7-day pretreatment with daily doses of cocaine enhanced the neurochemical changes induced by multiple doses of METH in the dopaminergic and serotonergic systems of the basal ganglia and frontal cortex.
Abstract: We have evaluated the responses of rat monoaminergic pathways to combinations of cocaine and methamphetamine (METH) administrations and found that these two commonly abused stimulants significantly interact. A 7-day pretreatment with daily doses of cocaine enhanced the neurochemical changes induced by multiple doses of METH in the dopaminergic and serotonergic systems of the basal ganglia and frontal cortex. When cocaine was administered concurrently, it attenuated or blocked the serotonergic changes caused by multiple doses of METH, but it did not interfere with the METH-mediated changes in the dopaminergic system.
Patent•
10 Nov 1988