Showing papers on "Oxazolidine published in 1980"

Antidepressant aryl derivs of azolone(s) - prepd. e.g. from hydroxymethyl-nitrobenzyl-oxy:phenyl oxazolidine thione

Abstract: N-Aryl azolones of formula (I) are new. X is S; A is O; R1 is H; R2 is -CH2-O2C-Et and R is (II); or R2 is -CH2OH and R is (III) NC-CH2-CH2-CH2O or NC-CH2-CH2CH2CH2O; or R2 is MeO-CH2- and R is (IV),(V) CH3-CHMe-CH2CH2O-, (VI) or NC-CH2CH2CH2CH2O-; or R2 is EtO-CH2- or CH3-CH2CH2OCH2 and (VII) in an alternative, X is O; A is S; R1 is H; R2 is MeO-CH2-; and R is (VIII). (I) are antidepressant agents. The cpds. are prepd. by various conventional methods depending on the value of individual substituents.

Self-crosslinking cationic binders and their preparation

Abstract: The binders are reaction products of (A) adducts of ammonia or diamines and epoxide compounds with (B) partially or fully blocked diisocyanates or polyisocyanates, with or without (C) diamines or polyamines, the amino-β-hydroxyalkyl groups of component (A) preferably having been reacted--prior to their reaction with component (B)--with a carbonyl compound, preferably an aldehyde, to form an oxazolidine ring. The reaction products are ultimately protonized with an acid. These binders are used for the cathodic electrocoating of metallically conductive articles.

Preparation of indole derivative

Abstract: PURPOSE: To obtain the titled compound useful for the remedy and prevention of arrhythmia and atrial fibrillation by a simple and economical means in high purity and yield, by reacting 4-hydroxyindole with an oxazolidine derivative in the presence of water and a basic substance. CONSTITUTION: A compound of formula I (Y is H or equivalent amount of a metallic atom) is reacted with an oxazolidine derivative of formula I (R is alkyl; X is halogen, alkyl or arylsulfonyloxy) in the presence of water and a basic substance, e.g. potassium hydroxide, in a solvent, e.g. dimethylformamide, preferably at 50W 150°C, to give a compound of formula III. The compound of formula II is synthesized by alkylating the nitrogen atom at the 3-position of a 5-halogenomethyloxazolidin-2- one with an alkyl halide. COPYRIGHT: (C)1982,JPO&Japio

synthesis of 2-deoxyfortimicins and 1-deamino-2-deoxy-2-epi-aminofortimicins via 2-O-methanesulfonylfortimicin B.

Abstract: The synthesis of 2-deoxyfortimicins A (15) and B (11) and 1-deamino-2-deoxy 2-epi-amino-fortimicins A (18) and B (12) is described. Two routes have been developed for synthesis of the key intermediate 2-O-methanesulfonylfortimicin B (7). One route involves selective blocking of fortimicin B with N-benzyloxycarbonyl groups followed by formation of a 4, 5-salicylaldehyde oxazolidine derivative. Subsequent mesylation followed by deblocking gave 7. A more efficient route to 7 involves concomitant salicylaldehyde SCHIFF base and 4, 5-oxazolidine formation followed by mesylation and hydrolysis. The formation of 1, 2(R)-epiminofortimicinB (8) from 7 followed by RANEY nickel reduction gave 2-deoxyfortimicin B and 1-deamino-2-deoxy-2-epi-aminofortimicin B, which were converted to the corresponding fortimicin A derivatives by selective N-blocking. N-acylation and subsequent deblocking. The antibacterial activities of the new fortimicin A derivatives are presented.

Process for producing water-dilutable binders containing oxazolidine groups

Abstract: of the Disclosure A thermosetting binder which is water-dilutable upon at least partial neutralisation with an acid to give a cathodically depositable coating composition, said binder being the reaction product of (a) an isocyanate group-containing monoadduct of an N-hydroxyalkyloxazolidine and a hydrocarbon diisocyanate, and (b) a hydroxyl group-containing polycondensation, polymerisation or polyaddition resin, the proportions of (a) and (b) being such that the binder has an amine value of from 30 to 100mg KOH/g.

Water-dilutable binders carrying oxazolidine groups

Abstract: Binders water-dilutable upon neutralization with inorganic and/or organic acids comprising the reaction product of (A) a monoadduct of an N-hydroxyalkyloxazolidine and a diisocyanate with (B) a hydroxyl group containing polymer, the ratio of (A) and (B) adjusted to provide a final product with an amine value sufficient to provide water dilutability upon acid neutralization, and a process for the formation of the binders, is described. The binders, upon stoving, provide films with good resistance characteristics and have reduced losses.

Spirooxazolidines and thiazolidines as herbicide antidotes

Abstract: N-haloacyl oxazolidines or thiazolidines substituted in the 2-position with the cyclohexyl spiro group included in a two-part herbicide system comprising a first-part of one or more thiolcarbamate herbicides or haloacetanilide herbicides and a second-part of an effective oxazolidine or thiazolidine antidote compound of the formula (FORMULA) in which X is oxygen or sulfur, R is lower haloalkyl, R1 is hydrogen or lower alkyl and R2 is hydrogen or phenyl and the methods of use.

5-Substituted oxazolidines having herbicide antidote activity, production thereof, herbicidal compositions containing them, use thereof in preventing injury to crops and crop seeds coated therewith

Abstract: N-haloacyl oxazolidines substituted in the 5-position with oxy or thio containing groups of the formula A-Compounds: wherein XR, is phenoxy, R is selected from the group consisting of haloalkyl, where halo is chloro or bromo, and p-methyl phenylsulfonylamido; and R 2 and R 3 are independently selected from lower alkyl; B-Compounds: wherein X is selected from the group consisting of oxygen and sulfur; R 1 is selected from the group consisting of alkyl and alkenyl; R is selected from the group consisting of haloalkyl, alkylthio and p-tolylsulfonamido; R and R 3 are independently selected from the group consisting of hydrogen and lower alkyl, each having 1 to 3 carbon atoms, inclusive; provided that the carbon content of R, + R 2 is less than or equal to 6 carbon atoms and further provided that when XR, is alkylthio, then R is other than haloalkyl having 3 to 4 carbon atoms inclusive, and provided that when XR 1 is methoxy, R is other than 2,3-dibromopropyl; and in addition a compound selected from the group of compounds consisting of 2,2-dimethyl-3(3-bromopropionyl)5-pentoxymethyl oxazolidine; 2,2-dimethyl-3(5-chlorovaleryl)5-isopropoxymethyl oxazolidine; 2,2-dimethyl-3(5-chlorovaleryl)-5-allyloxymethyl oxazolidine; C-Compounds: wherein X is oxygen or sulfur and R is alkyl; R is selected from the group consisting of haloalkyl, and alkoxy carboalkyl; R 2 is selected from the group consisting of phenyl, p-chlorophenyl and p-bromophenyl; and R, is selected from the group consisting of hydrogen and methyl. These new compounds have utility as active herbicidal antidotes to protect against and decrease crop injury when used with thiolcarbamate herbicides, and may be when applied in various ways to achieve this. These ways include soil treatment, seed treatment and in-furrow treatment. Improved herbicidal compositions comprising a first-part of one or more thiolcarbamate herbicides and a second part of an effective antidote compound therefor as defined above are disclosed.

Process for the preparation of N-aryl-oxazolidine-2,4-diones

Abstract: Verfahren zur Herstellung von N-Aryloxazolidin-2,4-dionen durch Umsetzung eines Nitrobenzols mit einem 2-Hydroxycarbonsaureester und Kohlenmonoxid in Gegenwart von Selen und einer basischen Verbindung bei erhohtem Druck und erhohter Temperatur. A process for preparing N-Aryloxazolidin-2,4-diones by reacting a nitrobenzene with a 2-hydroxycarboxylic acid ester and carbon monoxide in the presence of selenium and a basic compound at elevated pressure and elevated temperature. N-Aryloxazolidin-2,4-dione sind wertvolle Wirkstoffe und Ausgangstoffe fur die Herstellung von Pflanzenschutzmitteln, Farbstoffen und Pharmazeutika. N-Aryloxazolidin-2,4-diones are valuable active ingredients and raw materials for the production of pesticides, dyes and pharmaceuticals.

Mercaptoacyl derivatives of 4-oxazolidine-carboxylic acids

Abstract: This invention is directed to compounds of the formula ##STR1## which are useful as hypotensive agents.

Spiro derivatives of 3-(3,5-dihalophenyl)-oxazolidine-2-thion-4-ones, processes for their preparation and their use as fungicides

Abstract: Neue Spiro-Derivate von 3-(3,5- Dihalogenphenyl)-oxazolidin-4- thion-4-onen der allgemeinen Formel I New spiro derivatives of 3- (3,5-dihalophenyl) oxazolidin-4-thion-4-ones of the general formula I in welcher in which X und Y gleich oder verschieden sind und fur Halogen stehen und X and Y are the same or different and represent halogen and n fur die ganzen Zahlen 2 oder 3 steht, n represents the integers 2 or 3, mehrere Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide. several processes for their preparation and their use as fungicides.

3'(3,5-Dichlorophenyl)-spiro(3-oxabicycloc[3.1.0]hexane)-6,5'-oxazolidine-2',4'-dione

Abstract: Compounds of the formula I ##STR1## wherein at least one of the substituents R 1 , R 2 , R 3 and R 4 is C 1 -C 4 alkyl and each of the others independently is hydrogen or C 1 -C 4 alkyl, or, if R 1 and R 3 are both hydrogen, R 2 and R 4 can form a C 2 -C 4 alkylene bridge in which one CH 2 member can be replaced by oxygen. These compounds possess valuable microbicidal properties, and they can be used in actual practice by themselves, or in the form of pesticidal compositions, especially for protecting cultivated plants from attack by fungus. The compounds of formula I have both a residual-protective and a systemic action.

2-(3-Substituted amino-2-hydroxypropoxy)-3-piperidino pyrazines for use in treating hypertension

Abstract: 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds optionally having substituents in the 5 and/or 6 positions, possessing β-adrenergic blocking properties are described. The products are prepared by reaction of a 2-chloro (or hydroxy) pyrazine with a 5-hydroxymethyl (or sulfonyloxymethyl) oxazolidine followed by acid hydrolysis.