Showing papers on "Protein–protein interaction published in 1971"

New theory of the control of protein concentrations in animal cells.

Abstract: THE molecular basis for the regulation of intracellular concentrations of protein has been studied intensively since the discovery of the transfer of genetic information from DNA to RNA to protein1, 2. We wish to present experimental evidence in support of a model which considers regulation by post-translational events. This model takes into account the contributions of synthesis, degradation and protein interactions to the regulation of intracellular protein concentrations. The model explains how protein concentrations could change within a cell while rates of transcription and translation remained constant. Although the experimental evidence in support of the model was collected from studies of the lactate dehydrogenase (LDH) system in the rat, the model may be generally applicable to other subunit proteins and other organisms.