Showing papers on "Sexual dysfunction published in 1987"
TL;DR: Anorgasmia persisted with minimal tolerance over the five months that clomipramine was taken, and men and women were equally affected.
Abstract: Forty-six patients with obsessive-compulsive disorder undergoing a double-blind controlled study of clomipramine and placebo were interviewed to assess changes in sexual function. Of 33 patients with previously normal organism, nearly all of the 24 on clomipramine developed total or partial anorgasmia; none of the 9 on placebo did so. Anorgasmia persisted with minimal tolerance over the five months that clomipramine was taken. Men and women were equally affected. Sexual side-effects are easily missed without a structured interview, and can detract from the value of drug treatment.
201 citations
TL;DR: Data revealed that both the PEs and NPEs were equally accurate in assessing their level of physiological sexual arousal, and several hypotheses regarding the nature and etiology of premature ejaculation were evaluated.
Abstract: The hypothesis that premature ejaculators (PEs) are less able than nonpremature ejaculators (NPEs) to evaluate accurately their level of physiologically determined sexual arousal was tested. Twenty-six men (13 PEs and 13 NPEs) viewed a variety of videotaped vignettes, some of which were excerpts from sexually explicit films. Concurrent subjective (selfreport) and objective (plethysmograph) ratings of sexual arousal were taken. Data revealed that both the PEs and NPEs were equally accurate in assessing their level of physiological sexual arousal. These results and those from a sexual history questionnaire were used to evaluate several hypotheses regarding the nature and etiology of premature ejaculation.
93 citations
TL;DR: La dyspareunie et les troubles de l'activite sexuelle sont tres nettement plus frequents dans le 1er groupe.
Abstract: 50 femmes atteintes de syndrome de colon irritable, 30 atteintes d'ulcere duodenal et 30 de maladie inflammatoire intestinale, toutes exemptes de troubles psychiatriques, sont interrogees et examinees. La dyspareunie et les troubles de l'activite sexuelle sont tres nettement plus frequents dans le 1er groupe
92 citations
TL;DR: Sexual function after rectal excision for cancer was studied in 25 male patients who were less than 60 years of age and exhibited normal sexual activity preoperatively and advanced patient age and very low resection were the two main factors effecting sexual dysfunction after major rectal operation.
Abstract: Major rectal operation, that is, abdominoperineal or anterior resection, for cancer frequently damages the autonomic pelvic nerve supply with resultant sexual dysfunction. The anatomic characteristics and function of the autonomic nervous system in the pelvis has been reviewed. Sexual function after rectal excision for cancer was studied in 25 male patients who were less than 60 years of age and exhibited normal sexual activity preoperatively. Of nine patients who had abdominoperineal resection, four were impotent and two reported no ejaculation with normal potency postoperatively. Of 4 patients who had high anterior resection, only 1 reported no ejaculation, whereas of 12 patients with low anterior resection, 4 were impotent and 3 reported no ejaculation. A higher incidence of sexual dysfunction was noted after abdominoperineal resection compared with after anterior resection (66 percent and 50 percent, respectively). However, the incidence after low and very low anterior resection was comparable with that after abdominoperineal resection (58 percent and 66 percent, respectively). Advanced patient age and very low resection were the two main factors effecting sexual dysfunction after major rectal operation. Although we believe that careful operative technique might reduce the incidence of sexual disturbances attributable to sympathetic fiber damage, avoidance of parasympathetic damage during operation cannot be accomplished because the most likely site of injury, namely the periprostatic plexus, is usually within the operative field, the exception being cases in which the tumor is small, thus allowing preservation of the rectoprostatic fascia.
88 citations
TL;DR: In an attempt to detail cognitive processes during anxiety and sexual arousal, 16 heterosexual males were presented with brief erotic audiotapes simultaneous with four levels of shock threat, revealing that tolerance shock threat decreased tumescence (p<.05).
Abstract: In an attempt to detail cognitive processes during anxiety and sexual arousal, 16 heterosexual males were presented with brief erotic audiotapes simultaneous with four levels of shock threat (no shock, half tolerance, tolerance, and twice tolerance threat) Subjects were instructed to pay close attention to the audiotapes, following which a sentence recognition task was administered to assess stimulus-focused attention Additionally at these times, they were given a thought-listing task and completed a series of affect ratings Tumescence and subjective arousal were monitored continuously during the erotic stimuli Results revealed that tolerance shock threat decreased tumescence (p<05) In contrast, recognition memory was greatest during tolerance shock threat and diminished during twice tolerance shock threat, which also produced increased reports of emotional stales Issues regarding the relation between cognition and sexual arousal are discussed, including implications for understanding sexual dysfunction
82 citations
TL;DR: Although cancer patients and spouses of patients reported similar rates of sexual dysfunction before cancer diagnosis, after cancer treatment husbands and wives of patients maintained stable sexual function, while dysfunctions increased dramatically in all categories except premature ejaculation for patients.
Abstract: A program of sexual rehabilitation in a cancer center evaluated 308 men and 76 women, using a structured interview. The site of the malignancy was pelvic or genital in 79% of men and 58% of women. Most patients (73%) had one or two sessions of sexual counseling, but therapy was more intensive for about a quarter of patients. Partners were included in counseling by 28% of women and 56% of men. Although cancer patients and spouses of patients reported similar rates of sexual dysfunction before cancer diagnosis, after cancer treatment husbands and wives of patients maintained stable sexual function, while dysfunctions increased dramatically in all categories except premature ejaculation for patients. Patients who were older or had pelvic/genital tumors were more likely to develop arousal-phase sexual dysfunctions. Psychological distress was correlated with rates of low sexual desire and dyspareunia in both men and women. The success of treatment in reversing sexual dysfunction was rated by the therapist in 118 cases. Patients who were younger, who were not clinically depressed, and who had less conflicted marriages had more positive outcomes. Good outcome was also associated with a longer duration of treatment.
71 citations
TL;DR: This work proposes the coexistence of central neuroendocrine disorders in the regulation of gonadotropin secretion and evidence supporting such a hypothesis is discussed.
58 citations
TL;DR: Generalization from marital therapy to sexual functioning was greater than generalization from sex therapy to marital adaptation, and treatment gains were more pronounced and more comprehensive for the couples who received the combination of marital and sex therapy.
Abstract: A controlled treatment trial was conducted with couples in which the woman suffered from secondary forms of sexual dysfunction. To test whether marital therapy is helpful in enhancing the effectiveness of symptom-specific therapy for sexual dysfunction, two treatment conditions were compared to a waiting list control group. All couples received 12 sessions of therapy directed to the sexual symptom. One half of the couples received nine sessions of relaxation and information before sex therapy, and the other half, nine sessions of marital therapy before sex therapy. Whereas both treatment conditions showed clinical and statistical improvement at termination and follow-up, treatment gains were more pronounced and more comprehensive for the couples who received the combination of marital and sex therapy. Generalization from marital therapy to sexual functioning was greater than generalization from sex therapy to marital adaptation.
58 citations
TL;DR: Findings suggest psychological causes for the sexual problems and a need for therapeutic intervention in male alcohol addicts and a group of addicts with sexual dysfunction who were treated by a behavioral treatment format.
Abstract: Study 1 examined the prevalence of sexual dysfunction in 101 male alcohol addicts. Inpatients at a clinic for alcoholism were investigated by questionnaire about their sexual functioning and by hormonal data. Three-quarters had erectile dysfunction, loss of libido, and premature or delayed ejaculation. A follow-up study was done 9 months after the end of treatment. No significant differences in the prevalence of sexual dysfunction were found between the two points of measurement. All patients had normal levels of plasma testosterone at the beginning and end of inpatient treatment. These findings suggest psychological causes for the sexual problems and a need for therapeutic intervention. Study 2 reports on a group of addicts with sexual dysfunction who were treated by a behavioral treatment format. Follow-up results indicate that the treatment group showed significantly less sexual dysfunction than an untreated control group.
56 citations
TL;DR: In this, the first controlled study, liver disease per se appears to cause sexual dysfunction and sex hormone changes but these changes are amplified by ethanol.
Abstract: Men with liver disease are hypogonadal and feminized. European workers consider the liver disease itself to be the major factor but American workers blame alcohol consumption. We studied sexual dysfunction and sex hormones in three matched groups of men; controls (n = 22), those with alcoholic liver disease (n = 21), and those with non-alcoholic liver disease (n = 21). Men with alcoholic liver disease had more sexual dysfunction. Testosterone and androstenedione concentrations were lower and oestradiol and dehydroepiandrosterone sulphate levels were raised in the liver disease groups. The changes were greatest in the alcoholic liver disease group. In this, the first controlled study, liver disease per se appears to cause sexual dysfunction and sex hormone changes but these changes are amplified by ethanol.
55 citations
Journal Article•
TL;DR: After 4 weeks' treatment with buspirone, sexual function was normalized in 8 of 10 patients with generalized anxiety disorder andBuspirone appears to offer a clinical advantage over existing anxiolytics, which are usually associated with impairment of sexual function.
Abstract: After 4 weeks' treatment with buspirone, sexual function was normalized in 8 of 10 patients with generalized anxiety disorder. Nine of the patients had reported decreased sexual function before treatment. Buspirone appears to offer a clinical advantage over existing anxiolytics, which are usually associated with impairment of sexual function.
TL;DR: It would appear that TURP has a significant effect on sexual function which cannot be accounted for by the stress of surgery or the age of the population undergoing operation.
Abstract: One of the major and disconcerting complications of prostatectomy is impotence. Several studies have reported only a small reduction in potency rates following prostatectomy but have not examined the effect of surgery per se on a group of men in whom one could expect a significant incidence of reduced potency. In order to rectify this defect, a prospective study was undertaken to assess the effect of transurethral resection of the prostate (TURP) and other general surgical procedures on two age-matched populations. In all cases potency and ejaculatory function and frequency of intercourse were assessed pre- and post-operatively. Potency was retained in 86% of men undergoing TURP and in all of the men undergoing general surgical procedures (p less than 0.01). Of those men who indicated that they were capable of having sexual intercourse prior to operation, 88% were unaffected by TURP. In the general surgical group 97% were unaffected. Thus it would appear that TURP has a significant effect on sexual function which cannot be accounted for by the stress of surgery or the age of the population undergoing operation.
TL;DR: In the treatment of men and women with bladder cancer, the sexual function morbidity of radical cystectomy is described in data from prospective interview studies, and sexual function in patients with penile, urethral, or renal cell carcinoma is briefly reviewed.
Abstract: With the advent of effective treatment for urologic cancer, the preservation of sexual function and fertility has become an important goal. Some cancer treatments damage the physiological systems involved in reproduction. All have a psychological impact on sexuality. For men with prostate cancer, current issues in sexual rehabilitation include the debate on nerve-sparing radical prostatectomy, the role of vascular damage in causing erectile dysfunction after radiotherapy, and the need for a better understanding of hormonal effects on central and peripheral mechanisms of sexual function. In the treatment of men and women with bladder cancer, the sexual function morbidity of radical cystectomy is described in data from prospective interview studies. Sexual desire and orgasm remain normal after surgery despite disruption of the genital vasocongestion accompanying sexual arousal. Long-term follow-up studies of testicular cancer patients suggest that some increase in sexual dysfunction does occur. Infertility remains a concern for a subgroup of younger, childless men. Attempts to modify or eliminate retroperitoneal lymphadenectomy are discussed, as is recovery of spermatogenesis after chemotherapy and radiotherapy. Sexual function in patients with penile, urethral, or renal cell carcinoma is briefly reviewed.
TL;DR: A man riding a stationary bicycle experienced transient tight sensations around the head of his penis during the exercise and progressive impairment of sexual potency over a period of more than one year, and one month after the patient discontinued the bicycle exercises, sexual potency returned.
Abstract: A man riding a stationary bicycle experienced transient tight sensations around the head of his penis during the exercise and progressive impairment of sexual potency over a period of more than one year. Lowering the bicycle seat terminated the bouts of impaired penile sensation, and one month after the patient discontinued the bicycle exercises, sexual potency returned. The course supported an ischemic mechanism for the abnormal penile sensation and a neural mechanism for impotence. Impotence has been associated with both vascular and neural lesions, and there is evidence for both vascular and neural compression in the perineal area during bicycle riding. A relationship between sexual dysfunction and bicycling may be more common than formerly suspected.
TL;DR: During a fourteen-month period, 497 men were evaluated for a primary complaint of erectile dysfunction, and one hundred forty-seven of these men (91.3%) had organic pattern impotence, and 14 (8.7%) had psychogenic patternImpotence.
Journal Article•
TL;DR: Its potential clinical applications are discussed, including use as an adjunct to neuroleptics for treating psychosis, management of specific psychotropic side effects, alternative treatment for certain pain syndromes, and a primary treatment for severe agitation, atypical psychosis, and anxiety disorders.
Abstract: Clonazepam is a high-potency benzodiazepine labeled for use as an anticonvulsant. Increasingly, clonazepam has been used in the treatment of a variety of psychiatric disorders. The authors discuss its potential clinical applications, including (1) use as an adjunct to neuroleptics for treating psychosis, (2) management of specific psychotropic side effects, (3) alternative treatment for certain pain syndromes, and (4) a primary treatment for severe agitation, atypical psychosis, and anxiety disorders. Apparent treatment-emergent side effects including depression, disinhibition, and sexual dysfunction are also discussed.
TL;DR: Within the aging population itself, sexual attitudes, lack of knowledge concerning the effects of aging on sexual response as well as motivational factors have been implicated in the decline of sexual activity with age.
TL;DR: Evaluating sexual activity in advanced age indicates that the interest in sexuality continues in elderly men although the form of sexual expression changes from active sexual intercourse to a self-pleasuring/autoerotic form.
Abstract: Sexual behavior was evaluated in 81 men aged 60-71 years (34 men aged 60-65 years and 47 men aged 66-71 years) All subjects were married, physically healthy, and with no psychopathology or marital problems Sexual function was evaluated by a self-report three-point rating scale Thirty-six percent of the whole study population reported impotence, with no significant difference between the two age groups About half of the total population reported regular masturbatory activity A decline in frequency of sexual intercourse and an increase in frequency of masturbation in subjects aged 66-71 years as compared to subjects aged 60-65 indicates that the interest in sexuality continues in elderly men although the form of sexual expression changes from active sexual intercourse to a self-pleasuring/autoerotic form Evaluation of sexual activity in advanced age is recommended and appropriate therapy in case of sexual dysfunction should be offered to elderly men
TL;DR: Reviewing studies of sex and menopause and etiological considerations with regard to ovarian hormones and sexual dysfunction discusses ways in which the clinician can help the menopausal woman and her partner understand and deal with sexual dysfunction.
TL;DR: The sexual functions of 101 patients who had undergone bilateral retroperitoneal lymph node dissection for stage I or II nonseminomatous testicular cancer between 1969 and 1982 are concerns.
Abstract: This study concerns the sexual functions of 101 patients who had undergone bilateral retroperitoneal lymph node dissection for stage I or II nonseminomatous testicular cancer between 1969 and 1982. All patients were without evidence of disease after at least 4 years of follow-up. Antegrade ejaculation was present in 12 patients, while 89 patients experienced "dry ejaculation." Urine collected after intercourse or masturbation from 75 patients with dry ejaculation showed retrograde ejaculation in 55 and lack of ejaculatory emission into the urethra in 20 patients. Regarding other sexual functions, 17 patients had a diminished sexual desire (especially those patients who had received radiotherapy), 12 experienced difficulty reaching organism, and 6 complained of erectile dysfunction. The incidence of a contralateral hydrocele developing after retroperitoneal lymph node dissection seems to correlate with ligation of the contralateral spermatic vessels and their lymphatics. A review of the literature is presented comparing the types of dissection with the incidence of sexual disorders after retroperitoneal lymph node dissection. Since preserving normal ejaculation and fertility is important, a modified or unilateral retroperitoneal lymph node dissection, when required, is advocated. In patients, with stage I disease the therapy may be limited to an orchiectomy without lymph node dissection. In patients with retroperitoneal lymph node metastases combination chemotherapy with cisplatin and tumor excision gives good results. Patients with true retrograde ejaculation can be treated with alpha-sympathomimetic drugs such as imipramine HCl, and thus be offered the chance of fatherhood by coitus.
TL;DR: Tests used to evaluate the changes in sexual behavior, showed a significant decrease in sexual desire, sexual excitement phase (erection) and frequency of sexual relations in the digoxin-treated group.
Abstract: The effect of long-term administration of digoxin on sexual dysfunction was investigated in correlation to plasma androgens level. The patients of the experimental (digoxin-treated) and control (without digoxin) groups were of similar cardiac functional capacity and age (25–40 years) and were randomly selected from the rheumatic heart disease patients. A subjective assessment of sexual behavior was carried out, using parameters such as sexual desire, sexual excitement, and frequency of sexual relations. Personal interviews and questionnaires were also used for the evaluation of sexual behavior. The findings support various reports concerning digoxin effect on plasma levels of testosterone (the difference in the mean was significant). The effect on plasma levels of androstendione and dehydroepiandrosterone in the experimental group as compared to the control group were not significant. Tests used to evaluate the changes in sexual behavior, showed a significant decrease in sexual desire, sexual exc...
TL;DR: Three aspects of symptomatology significantly discriminated the criterion groups and the single best predictor was the presence or absence of early morning erections as reported by the patient.
Abstract: The use of sexual symptomatology to differentiate psychogenic from organogenic impotence was studied. All patients were independently classified based on the evaluation of a minimum of one night of nocturnal penile tumescence recording, a sleep lab technician's rating of penile turgidity of erections, Doppler determination of penile blood flow, determination of serum prolactin and testosterone levels. Three aspects of symptomatology significantly discriminated the criterion groups. The single best predictor was the presence or absence of early morning erections as reported by the patient.
Patent•
06 May 1987TL;DR: Dehydroepiandrosterone and acceptable salts thereof are utilized for sexual disfunction therapy as mentioned in this paper, and they are used for disfunctioning patients in sexual disaction therapy.
Abstract: Dehydroepiandrosterone and acceptable salts thereof are utilized for sexual disfunction therapy
TL;DR: In this paper, sexual function in 24 patients with major affective disorders who were given prophylactic lithium treatment was compared with that of a control group of surgical outpatients with no known psychiatric disease.
Abstract: Sexual function in 24 patients with major affective disorders who were given prophylactic lithium treatment was compared with that of a control group of surgical outpatients with no known psychiatric disease. Changes in sexual function during lithium treatment were also recorded retrospectively. Sexual dysfunctions were described by about one-fourth of both female patients and controls. About one-third of the male patients and controls reported sexual dysfunctions. We cannot exclude tha lithium in combination with other psychotropic drugs may increase the frequency of sexual dysfunction. Changes in sexual function during lithium treatment were reported by one-fourth of the patients. Of these, four reported a positive influence of the treatment and five a negative influence. Statistically, significantly more patients than controls were dissatisfied with their present sex life.
TL;DR: It is concluded that prolonged bladder and sexual dysfunction, caused by spinal cord inflammatory insult, may persist despite a systemic neurological recovery, and bladder management guided by initial and followup urodynamics is recommended.
Patent•
30 Jan 1987TL;DR: Buspirone and its pharmaceutically acceptable salts are useful in treating patients of both sexes suffering from sexual dysfunction as discussed by the authors, however, they are not suitable for medical use.
Abstract: Buspirone and its pharmaceutically acceptable salts are useful in treating patients of both sexes suffering from sexual dysfunction.
Journal Article•
TL;DR: Sixteen analogue scales were designed to measure drug- and illness-related changes in three dimensions of sexual function: interest, arousal, and performance and confirmed the three clinical factors.
Abstract: Sixteen analogue scales were designed to measure drug- and illness-related changes in three dimensions of sexual function: interest, arousal, and performance. An orthogonal principal component factor analysis confirmed the three clinical factors. Retest reliability ranged between .80 and .94. Normals (N = 30) reported significantly better functioning than did psychiatric outpatients (N = 30).
TL;DR: The use of androgens in the treatment of gynecic disorders has had few adherents because of the belief generally held that androgen administration to the female patient is antiphysiologic and antipharmacologic as discussed by the authors.
01 Jul 1987
TL;DR: Treatment was associated with a significantly increased prevalence of erectile dysfunction and the prevalence of ejaculatory difficulty was age-related only occurring in men over 40 years of age and occurred more frequently in treated patients than untreated patients.
Abstract: A questionnaire containing questions on sexual functioning was sent to 800 hypertensive patients. A response rate of 68.3% was obtained. Of these 60 men and 100 women did not have intercourse. 208 men reported on their erectile ability and 201 men reported on their ejaculatory function. The prevalence of erectile inadequacy was age related in the treated patients, and ranged from 27% in 20–39 years to 70% in patients over 60 years. Treatment was associated with a significantly increased prevalence of erectile dysfunction (untreated 26%, treated 55%; P≤0.01). The prevalence of ejaculatory difficulty was age-related only occurring in men over 40 years of age and occurred more frequently in treated (45%) than untreated (14%) patients (P≥0.01). 178 women reported on their ability to become sexually arroused and to attain orgasm. 22% of women reported never having difficulty becoming aroused and 8% reported that they always experienced orgasm. The prevalence of arousal and orgasmic dysfunction was not...
TL;DR: Clinical interviews with the use of a standard examination format were used to determine sexually atypical experiences in 373 women, finding patients with a sexual dysfunction had been the object of sexual abuse in childhood significantly more often than women in the other groups.
Abstract: Clinical interviews with the use of a standard examination format were used to determine sexually atypical experiences in 373 women. The women were divided into three groups. Group 1: 167 women in fertile marriages, Group 2: 102 patients with sexual dysfunctions, Group 3: 104 patients of psychiatric outpatient clinics. Of these, 190 (50.9%) had encountered indecent exposure at least once; 76 women (20.4%) were the victims of attempted rape or rape; 60 women (16.1%) were sexually abused by an adult male prior to menarche; 36 women (9.6%) acknowledged homosexual contacts. Patients with a sexual dysfunction had been the object of sexual abuse in childhood significantly more often than women in the other groups.