A Cardile

TL;DR: Nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals.

TL;DR: It is reported that the NO/cGMP-dependent mitochondrial biogenesis is associated with enhanced coupled respiration and content of ATP in U937, L6, and PC12 cells, and that this stimulation isassociated with increased mitochondrial function, resulting in enhanced formation of ATP.

TL;DR: It is shown that a BCAA-enriched mixture (BCAAem) increased the average life span of mice and revealed an important antiaging role of BCAAs mediated by mitochondrial biogenesis in mammals.

TL;DR: It is demonstrated that eNOS expression was reduced, with a concomitant reduction of mitochondrial biogenesis and function, in white and brown adipose tissue and in the soleus muscle of 3 different animal models of obesity.

TL;DR: CB1 receptor blockade increases mitochondrial biogenesis in white adipocytes by inducing the expression of eNOS, linked to the prevention of high-fat diet–induced fat accumulation, without concomitant changes in food intake.