A
A D Sadovnick
Researcher at University of British Columbia
Publications - 156
Citations - 12981
A D Sadovnick is an academic researcher from University of British Columbia. The author has contributed to research in topics: Population & Multiple sclerosis. The author has an hindex of 57, co-authored 154 publications receiving 12541 citations. Previous affiliations of A D Sadovnick include British Columbia Ministry of Health & Vancouver Coastal Health.
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Journal ArticleDOI
A full genome search in multiple sclerosis
George C. Ebers,K Kukay,Dennis E. Bulman,A D Sadovnick,George P.A. Rice,Carol M. Anderson,H. Armstrong,K Cousin,Robert B. Bell,W Hader,Donald W. Paty,S Hashimoto,Joel Oger,Pierre Duquette,Sharon Warren,T. Gray,Paul O'Connor,Avindra Nath,A. Auty,Luanne M. Metz,Gordon S. Francis,J E Paulseth,T J Murray,William Pryse-Phillips,R. F. Nelson,Matthew L. Freedman,Donald G. Brunet,Jean-Pierre Bouchard,David A. Hinds,Neil Risch +29 more
TL;DR: The results support genetic epidemiological evidence that several genes interact epistatically to determine heritable susceptibility in multiple sclerosis.
Journal ArticleDOI
A genetic basis for familial aggregation in multiple sclerosis
TL;DR: Findings indicate that familial aggregation of MS is genetically determined: no effect of shared environment was detectable and the frequency of MS among first-degree non-biological relatives living with the index case was no greater than expected from Canadian population prevalence data and significantly less than for biological relatives.
Journal ArticleDOI
A Population-Based Study of Multiple Sclerosis in Twins
George C. Ebers,Dennis E. Bulman,A D Sadovnick,Donald W. Paty,Sharon Warren,Walter Hader,T J Murray,T. P. Seland,Pierre Duquette,T Grey +9 more
TL;DR: To the extent that the difference in concordance rates between monozygotic and dizygotic twins indicates genetic susceptibility, the results of this study show a major genetic component in susceptibility to multiple sclerosis.
Journal ArticleDOI
Twin concordance and sibling recurrence rates in multiple sclerosis
TL;DR: A longitudinal, population-based study of twins with multiple sclerosis (MS) in Canada, with a sample sufficiently large to permit additional informative comparisons, found MZ twin concordance was in excess of DZ twin Concordance.
Journal ArticleDOI
Depression and multiple sclerosis
A D Sadovnick,R. A. Remick,J. M. Allen,E. Swartz,I. M. L. Yee,K. Eisen,R. Farquhar,S. A. Hashimoto,John P. Hooge,Lorne F. Kastrukoff,W. Morrison,J. Nelson,Joel Oger,Donald W. Paty +13 more
TL;DR: Although there appears to be a very high rate of depression among multiple sclerosis patients, the data for their first-degree relatives do not support a clear genetic basis for this depression, or at least the same genetic basis that probably operates within families when depression occurs in the absence of MS.