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A. De Vries
Researcher at Utrecht University
Publications - 29
Citations - 1785
A. De Vries is an academic researcher from Utrecht University. The author has contributed to research in topics: Carcinogenesis & Gene. The author has an hindex of 20, co-authored 29 publications receiving 1743 citations.
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Journal ArticleDOI
Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA
A. De Vries,C. T. M. Van Oostrom,Frans M. A. Hofhuis,P.M. Dortant,R. J. W. Berg,F.R. de Gruijl,P. W. Wester,C. F. Van Kreijl,Peter J.A. Capel,H. van Steeg,Sjef J. Verbeek +10 more
TL;DR: It is concluded that the XPA-deficient mice strongly mimic the phenotype of humans with xeroderma pigmentosum, with a > 1,000-fold higher risk of developing sunlight-induced skin cancer.
Journal ArticleDOI
Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells
R. J. W. Berg,H.J. van Kranen,Heggert Rebel,A. De Vries,W. A. van Vloten,C. F. Van Kreijl,J.C. van der Leun,F.R. de Gruijl +7 more
TL;DR: Experimental results in the hairless mouse model unambiguously demonstrate that constitutive p53 alterations are causally related to chronic UVB exposure and that they are a very early event in the induction of skin cancer by UVB radiation.
Journal ArticleDOI
The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice.
Nicolas Dumaz,H.J. van Kranen,A. De Vries,R. J. W. Berg,P. W. Wester,C. F. Van Kreijl,Alain Sarasin,Leela Daya-Grosjean,F.R. de Gruijl +8 more
TL;DR: Comparison with mutation spectra from human skin carcinomas fully validates the merits of the hairless mouse model for studying the molecular mechanisms of skin carcinogenesis and identifies four distinct UV-B mutation hot spots.
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Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.
Ron Smits,Alex Kartheuser,Shantie Jagmohan-Changur,V Leblanc,Cor Breukel,A. De Vries,H.J. van Kranen,J.H.J.M. van Krieken,S L Williamson,Winfried Edelmann,Raju Kucherlapati,KhanPM,Riccardo Fodde +12 more
TL;DR: Although the genetic inactivation of Apc is involved in the initiating event of the human as well as murine intestinal tumorigenesis, tumor growth and progression follow different mutational pathways in these two species.
Journal ArticleDOI
On the photoluminescence of semiconducting titanates applied in photoelectrochemical cells
TL;DR: In this paper, the photoluminescence of the semiconducting titanates (TiO 2 (rutile), SrTiO 3, MgTiO3, K 1.8 Mg 0.9 Ti 7.1 O 16, and La 2 Ti 2 O 7, which are known to act as photoanodes in a photoelectrochemical cell was investigated.