C
Cor Breukel
Researcher at Leiden University Medical Center
Publications - 59
Citations - 4980
Cor Breukel is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Adenomatous polyposis coli & Familial adenomatous polyposis. The author has an hindex of 29, co-authored 59 publications receiving 4785 citations. Previous affiliations of Cor Breukel include Leiden University & Loyola University Medical Center.
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Journal ArticleDOI
Mutations in the APC tumour suppressor gene cause chromosomal instability
Riccardo Fodde,Jeroen Kuipers,Jeroen Kuipers,Carla Rosenberg,Ron Smits,Menno F. Kielman,Claudia Gaspar,Johan H. van Es,Cor Breukel,Joop Wiegant,Rachel H. Giles,Hans Clevers +11 more
TL;DR: It is concluded that loss of APC sequences that lie C-terminal to the β-catenin regulatory domain contributes to chromosomal instability in colorectal cancer.
Journal ArticleDOI
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors
Riccardo Fodde,Winfried Edelmann,Kan Yang,C. van Leeuwen,C Carlson,Beatrice Renault,Beatrice Renault,Cor Breukel,E Alt,Martin Lipkin,P M Khan +10 more
TL;DR: The results indicate that the Apc gene modification is a critical event in the initiation of intestinal tumor formation and results in an autosomal dominant predisposition toward development of spontaneous colonic and intestinal tumors in mice.
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The ‘just-right’ signaling model: APC somatic mutations are selected based on a specific level of activation of the β-catenin signaling cascade
Cristina Albuquerque,Cor Breukel,Rob B. van der Luijt,P Fidalgo,Pedro Lage,Frederik J. M. Slors,C. Nobre Leitão,Riccardo Fodde,Ron Smits +8 more
TL;DR: This study analyzed somatic APC point mutations and loss of heterozygosity in 133 colorectal adenomas from six FAP patients and proposed that this selection process is aimed at a specific degree of beta-catenin signaling optimal for tumor formation, rather than at its constitutive activation by deletion of all of the beta- catenin downregulating motifs in APC.
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Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
Menno F. Kielman,Maaret Rindapää,Claudia Gaspar,Nicole van Poppel,Cor Breukel,Sandra van Leeuwen,Makoto Mark Taketo,Scott Roberts,Ron Smits,Riccardo Fodde +9 more
TL;DR: The results imply that constitutive activation of the Apc/β-catenin signaling pathway results in differentiation defects in tissue homeostasis, and possibly underlies tumorigenesis in the colon and other self-renewing tissues.
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APC and Oncogenic KRAS Are Synergistic in Enhancing Wnt Signaling in Intestinal Tumor Formation and Progression
Klaus-Peter Janssen,Klaus-Peter Janssen,Paola Alberici,Hafida Fsihi,Claudia Gaspar,Cor Breukel,Patrick Franken,Christophe Rosty,Miguel Abal,Fatima El Marjou,Ron Smits,Daniel Louvard,Riccardo Fodde,Sylvie Robine +13 more
TL;DR: This KRAS-induced increase in Wnt/β-catenin signaling may enhance the plasticity and self-renewal capacity of the tumor, thus resulting in the drastically augmented tumor multiplicity and malignant behavior in compound mutant animals.