A
A. Elhammer
Researcher at University of Texas Southwestern Medical Center
Publications - 2
Citations - 462
A. Elhammer is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: LDL receptor & Gene. The author has an hindex of 2, co-authored 2 publications receiving 458 citations.
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Journal ArticleDOI
The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum.
Mark A. Lehrman,Wolfgang J. Schneider,Michael S. Brown,C. G. Davis,A. Elhammer,David W. Russell,Joseph L. Goldstein +6 more
TL;DR: A mutant low density lipoprotein receptor gene that produces a shortened receptor protein lacking three domains is described, which is responsible for the extraordinarily high incidence of familial hypercholesterolemia in Lebanon.
Journal ArticleDOI
Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.
C. G. Davis,A. Elhammer,David W. Russell,Wolfgang J. Schneider,Stuart Kornfeld,Michael S. Brown,Joseph L. Goldstein +6 more
TL;DR: It is concluded that: 1) the serine- and threonine-rich region of the LDL receptor is the site for addition of clustered O-linked carbohydrates; 2) the receptor contains a small number of isolated chains of O- linked carbohydrates in addition to the clustered chains; and 3) the clustered O -linked carbohydrates are not essential for LDL receptor function in cultured hamster fibroblasts.