M
Michael S. Brown
Researcher at Pacific Biosciences
Publications - 125
Citations - 24692
Michael S. Brown is an academic researcher from Pacific Biosciences. The author has contributed to research in topics: LDL receptor & Low-density lipoprotein. The author has an hindex of 73, co-authored 125 publications receiving 24121 citations. Previous affiliations of Michael S. Brown include University of California, Santa Cruz & University of Pennsylvania.
Papers
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Journal ArticleDOI
Knowledge-based analysis of microarray gene expression data by using support vector machines
Michael S. Brown,William Noble Grundy,David Lin,Nello Cristianini,Charles W. Sugnet,Terrence S. Furey,Manuel Ares,David Haussler +7 more
TL;DR: In this paper, a method of functionally classifying genes by using gene expression data from DNA microarray hybridization experiments is introduced based on the theory of support vector machines (SVMs).
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Hidden markov models in computational biology: applications to protein modeling
TL;DR: The results suggest the presence of an EF-hand calcium binding motif in a highly conserved and evolutionary preserved putative intracellular region of 155 residues in the alpha-1 subunit of L-type calcium channels which play an important role in excitation-contraction coupling.
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Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
Joseph L. Goldstein,Michael S. Brown,Richard G.W. Anderson,David W. Russell,Wolfgang J. Schneider +4 more
TL;DR: This data indicates that intracellular routes in the response of the immune system to EMT are regulated by Tournaisian reprograming, a type of ‘spatially aggregating’ behaviour.
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The LDL Receptor
TL;DR: The history of the LDL receptor is recounted by its codiscoverers to explain a genetic cause of heart attacks and introduce three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors.
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