A
A Fischer
Researcher at University of Paris
Publications - 134
Citations - 5538
A Fischer is an academic researcher from University of Paris. The author has contributed to research in topics: Immunodeficiency & Antibody. The author has an hindex of 37, co-authored 116 publications receiving 5250 citations.
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Journal ArticleDOI
Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.
Frédéric Altare,David A. Lammas,Patrick Revy,Emmanuelle Jouanguy,Rainer Doffinger,S Lamhamedi,Pamela Drysdale,Dagmar Scheel-Toellner,John Girdlestone,P. Darbyshire,M Wadhwa,Hazel M. Dockrell,Mike Salmon,A Fischer,Anne Durandy,Jean-Laurent Casanova,D S Kumararatne +16 more
TL;DR: The discovery of the first discovered human disease resulting from a cytokine gene defect suggests that IL-12 is essential to and appears specific for protective immunity to intracellular bacteria such as mycobacteria and salmonella.
Journal ArticleDOI
Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis.
Emmanuelle Jouanguy,Salma Lamhamedi-Cherradi,Frederic Altare,Marie-Claude Fondanèche,David Tuerlinckx,Stéphane Blanche,Jean-François Emile,Jean-Louis Gaillard,Robert D. Schreiber,Michael Levin,A Fischer,C Hivroz,Jean-Laurent Casanova +12 more
TL;DR: Partial IFNgammaR1 deficiency in this kindred caused curable tuberculoid BCG infection and clinical tuberculosis, and cells from the two siblings did not respond to low or intermediate concentrations, yet responded to high IFN-gamma concentrations.
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Incidence, severity, and prevention of infections in chronic granulomatous disease
TL;DR: A retrospective analysis of the occurrence of bacterial and fungal infections in patients who received trimethoprim-sulfamethoxazole and ketoconazole as infection prophylaxis indicated that the former was effective against bacterial infections but that ketoconzole provided no protection against Aspergillus infections.
Journal Article
Idiopathic disseminated bacillus Calmette-Guérin infection: a French national retrospective study.
Jean-Laurent Casanova,Stéphane Blanche,Jean-François Emile,Emmanuelle Jouanguy,S Lamhamedi,Frédéric Altare,Jean-Louis Stephan,Françoise Bernaudin,Pierre Bordigoni,Dominique Turck,A Lachaux,M Albertini,A Bourrillon,J P Dommergues,M A Pocidalo,F Le Deist,J L Gaillard,Claude Griscelli,A Fischer +18 more
TL;DR: Iiopathic disseminated BCG infection is a rare but severe complication of BCG vaccination that probably results from an as yet unknown genetically determined immunodeficiency condition that affects the killing of intracellular bacteria such as BCG and Salmonella.
Journal ArticleDOI
Autosomal Recessive Osteopetrosis: Variability of Findings at Diagnosis and During the Natural Course
E. J. A. Gerritsen,J. M. Vossen,I. H. G. Van Loo,Jo Hermans,M. H. Helfrich,Claude Griscelli,A Fischer +6 more
TL;DR: Autosomal recessive osteopetrosis seems to be a variable disorder with a poor prognosis, especially in children with early visual and hematologic impairment, and allogenic bone marrow transplantation remains the only curative approach.