Jean-Louis Gaillard

TL;DR: A previously unknown gene, inlA, is identified, which is necessary for the gram-positive intracellular pathogen Listeria monocytogenes to invade cultured epithelial cells and predicts an 80 kd protein, internalin.

TL;DR: Electron microscopic study demonstrated that bacteria from the nonhemolytic mutant remained inside phagosomes during cellular infection, whereas hemolytic bacteria from L. monocytogenes were released free within the cytoplasm, indicating that disruption of vacuole membranes by listeriolysin O-producing strains of L.monocytgenes might be a key mechanism allowing bacteria to escape from phagosome and to multiply unrestricted within cell cy toplasm.

TL;DR: It is strongly suggested that hemolysin is a major virulence factor implicated in the intracellular growth of L. monocytogenes, which is unable to grow in host tissues and were rapidly eliminated from the spleen and liver of infected mice.

TL;DR: Partial IFNgammaR1 deficiency in this kindred caused curable tuberculoid BCG infection and clinical tuberculosis, and cells from the two siblings did not respond to low or intermediate concentrations, yet responded to high IFN-gamma concentrations.

TL;DR: The results favor the view that listeriolysin O might play a major role during intracellular replication of L. monocytogenes, ultimately promoting death of infected macrophages in the acidic microenvironment, including macrophage phagosomes where bacteria presumably replicate.