John Girdlestone

TL;DR: A hotspot for human IFNGR1 small deletions that confer dominant susceptibility to infections caused by poorly virulent mycobacteria is reported.

TL;DR: The discovery of the first discovered human disease resulting from a cytokine gene defect suggests that IL-12 is essential to and appears specific for protective immunity to intracellular bacteria such as mycobacteria and salmonella.

TL;DR: It is reported that interferon‐β is the principal mediator of stromal cell‐mediated T cell rescue from apoptosis, and this mechanism may play a fundamental role in the persistence of T cells at sites of chronic inflammation; suggesting that chronic inflammation is an aberrant consequence of immunological memory.

TL;DR: Fractalkine is the first described cell-surface anchored chemokine and has potent mononuclear cell-directed adhesion and chemotactic properties as mentioned in this paper, and fractalkine mRNA was predominantly expressed in the major compartment, glomerular or tubulointerstitial, affected by disease and with the strongest expression localized to vascular sites local to inflammation.

TL;DR: Fractalkine blockade strategies could reduce mononuclear cell mediated tubular damage and improve graft survival following kidney transplantation, and may have a functional role in leucocyte adhesion and retention at selected tubular sites in acute renal inflammation.