A.J. LeCompte

TL;DR: Modulating both low dose insulin boluses and nutrition input rates challenges the current practice of using only insulin in larger doses to reduce hyperglycaemic levels and shows very tight control in safe glycaemic bands.

TL;DR: The proposed protocol is simple, cost effective, repeatable and highly correlated to the gold-standard clamp, and designed with physiological dosing, short duration, simple protocol, low cost and high repeatability.

TL;DR: A benchmark data set based on clinical patient data from SPecialized Relative Insulin and Nutrition Tables (SPRINT) studies provides a benchmark for comparing and analyzing performance in model-based glycemic control in a medical intensive care unit (ICU).

TL;DR: Model-based methods provide tighter, more adaptable one method fits all solutions, using methods that enable patient-specific modeling and control, and correlation between tightness of control and clinical outcome suggests that performance metrics, such as time in a relevant glycemic band, may provide better guidelines.

TL;DR: The multivariate clinical biomarker provides an effective real-time negative predictive diagnostic for severe sepsis and Examination of both inter- and intra-patient statistical distribution of this biomarker and sepsi score shows potential avenues to improve the positive predictive value.