A. John Clark

TL;DR: It is reported here that mice lacking heart‐type FABP (H‐FABP) exhibit a severe defect of peripheral (non‐hepatic, non‐fat) LCFA utilization, establishing a requirement for H‐FabP in cardiac intracellular lipid transport and fuel selection and a major role in metabolic homeostasis.

TL;DR: It is concluded that hES cell nuclei have a distinct nuclear architecture, especially at loci involved in maintaining pluripotency, which provides a framework within which other large-scale chromatin changes that may accompany differentiation can be considered.

TL;DR: Five founder transgenic sheep described carry genes designed to direct the production of human clotting factor IX or human αl–antitrypsin in milk and may ultimately provide a new source of these and other therapeutic proteins.

TL;DR: These OCT4‐EGFP clonal cell lines exhibit features similar to parental hESCs, are pluripotent, and are able to produce all three embryonic germ layer cells, and they will be invaluable for studying not only OCT4 function in hESC self‐renewal and differentiation but also the factors required for maintenance of undifferentiated h ESCs in culture.

TL;DR: Efficient generation of transgenic pigs using an equine infectious anaemia virus derived vector is demonstrated, indicating that lentiviral transgene delivery may be a general tool with which to efficiently generate transgenic mammals.