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C. Bruce A. Whitelaw
Researcher at University of Edinburgh
Publications - 20
Citations - 701
C. Bruce A. Whitelaw is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Transgene & Gene expression. The author has an hindex of 13, co-authored 20 publications receiving 590 citations. Previous affiliations of C. Bruce A. Whitelaw include The Roslin Institute.
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Journal ArticleDOI
Efficient generation of transgenic pigs using equine infectious anaemia virus (EIAV) derived vector.
C. Bruce A. Whitelaw,Pippa A Radcliffe,W. A. Ritchie,Ailsa J Carlisle,F M Ellard,Romi N. Pena,Jo M. Rowe,A. John Clark,Tim King,Kyriacos A. Mitrophanous +9 more
TL;DR: Efficient generation of transgenic pigs using an equine infectious anaemia virus derived vector is demonstrated, indicating that lentiviral transgene delivery may be a general tool with which to efficiently generate transgenic mammals.
Journal ArticleDOI
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity
Bhuvaneish T. Selvaraj,Matthew R. Livesey,Chen Zhao,Jenna M. Gregory,Owain T. James,Elaine M. Cleary,Amit K. Chouhan,Amit K. Chouhan,Angus B. Gane,Emma M. Perkins,Owen Dando,Simon G. Lillico,Youn-Bok Lee,Agnes L. Nishimura,Urjana Poreci,Sai Thankamony,Meryll Pray,Navneet A. Vasistha,Dario Magnani,Shyamanga Borooah,Karen Burr,David Story,Alexander McCampbell,Christopher Shaw,Peter C. Kind,Timothy J. Aitman,C. Bruce A. Whitelaw,Ian Wilmut,Colin Smith,Gareth B. Miles,Gareth B. Miles,Giles E. Hardingham,David J. A. Wyllie,Siddharthan Chandran +33 more
TL;DR: It is shown that increased expression of GluA1 AMPA receptor (AMPAR) subunit occurs in MNs with C9ORF72 mutations that leads to increased Ca2+-permeable AMPAR expression and results in enhanced selective MN vulnerability to excitotoxicity.
Journal ArticleDOI
Livestock 2.0 – genome editing for fitter, healthier, and more productive farmed animals
Christine Tait-Burkard,Andrea Doeschl-Wilson,Michael J. McGrew,Alan Archibald,Helen Sang,Ross D. Houston,C. Bruce A. Whitelaw,Mick Watson +7 more
TL;DR: Recent progress in the application of genome editing to farmed animal species is reviewed and the potential impact on the ability to produce food is discussed.
Journal ArticleDOI
CRISPR-Based Gene Drives for Pest Control.
TL;DR: It is timely to highlight two forms of sex-ratio distorting GDs that show potential as pest management tools.
Journal ArticleDOI
Multiple effects of genetic background on variegated transgene expression in mice.
Margaret L. Opsahl,M McClenaghan,Anthea Springbett,Sarah Reid,Richard Lathe,Alan Colman,C. Bruce A. Whitelaw +6 more
TL;DR: Although the BLG/7 transgene is expressed in a variegated manner, there was no generation-associated accumulated silencing of transgenes expression and suppression was not inherited, confirming that it is an inherent property of the transGene array at its site of integration.