A.M. Monro

TL;DR: The survey results support the value of in vivo toxicology studies to predict for many significant HTs associated with pharmaceuticals and have helped to identify HT categories that may benefit from improved methods.

TL;DR: The 1994 U.S. Physicians' Desk Reference reports the results of rodent carcinogenicity tests on 241 pharmaceutical agents, with a class label implying a carcinogenic hazard also attached to 9 estrogenic, 4 androgenic, and 3 progestogenic agents.

TL;DR: The more densely housed groups showed markedly reduced food consumption, slightly decreased mean body weights, and a smaller variance of body weights.

TL;DR: The histologic appearance and cytochemical characteristics of foci of hepatic cellular alteration, hepatic nodules, and hepatocellular carcinomas occurring in male Sprague-Dawley rats treated with the hypolipidemic agent clofibrate, with phenobarbital, or with diethylnitrosamine followed by phenobarBital were studied after treatment periods from 1 month to 2 years.

TL;DR: It is argued that in the carcinogenicity testing of drugs, biological measures of drug exposure may often be more relevant than the classical pharmacokinetic approaches applicable to reversible pharmacodynamic phenomena.