Denise Robinson

TL;DR: The survey results support the value of in vivo toxicology studies to predict for many significant HTs associated with pharmaceuticals and have helped to identify HT categories that may benefit from improved methods.

TL;DR: The results of this review support the use of data-derived uncertainty factors when appropriate scientific data are available and incorporation of all available scientific data into the risk assessment process fosters increased research and ultimately reduces uncertainty.

TL;DR: Consensus was reached regarding the significant intermediary roles of cell proliferation and PPAR-alpha receptor expression and activation in tumor formation and risk assessments based on tumor data may not be appropriate.

TL;DR: A large-scale collaborative research program to help to better characterize the responsiveness of several models proposed for use in carcinogenicity assessment and the database from these studies represents an important contribution to the future application of new models for human cancer risk assessment.

TL;DR: The weight of the scientific evidence concerning chloroform-induced tumors in rodents is consistent with and supports a cancer risk assessment methodology based on mode of action as the basis for establishing regulatory standards for this compound.