A
A P Farwell
Researcher at University of Massachusetts Amherst
Publications - 2
Citations - 128
A P Farwell is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Euthyroid & Deiodinase. The author has an hindex of 2, co-authored 2 publications receiving 123 citations.
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Journal ArticleDOI
Selenium deficiency and type II 5'-deiodinase regulation in the euthyroid and hypothyroid rat: evidence of a direct effect of thyroxine
Jean-Pierre Chanoine,Marjorie Safran,A P Farwell,P Tranter,D M Ekenbarger,S Dubord,Sharon Alex,J R Arthur,G J Beckett,L. E. Braverman +9 more
TL;DR: The decrease in brain and pituitary 5'D-II activity in selenium-deficient euthyroid rats is due to the T4-dependent increase in the turnover of the enzyme polypeptide, consistent with the finding that 5' D-II is not a seleno-enzyme.
Journal ArticleDOI
Effects of selenium deficiency on thyroid hormone economy in rats.
Jean-Pierre Chanoine,Marjorie Safran,A P Farwell,S Dubord,Sharon Alex,Scott Stone,J R Arthur,L. E. Braverman,Jack L. Leonard +8 more
TL;DR: It is suggested that increased T3 sulfate generation in selenium-deficient rats may lead to greater T3 availability through enterohepatic recycling of the iodothyronine and may explain why there are only minor changes in serum T3 concentrations in seLenium- deficient rats.