S
S Dubord
Researcher at University of Massachusetts Amherst
Publications - 3
Citations - 265
S Dubord is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Deiodinase & Selenium deficiency. The author has an hindex of 3, co-authored 3 publications receiving 254 citations.
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Journal ArticleDOI
The thyroid gland is a major source of circulating T3 in the rat.
Jean-Pierre Chanoine,Lewis E. Braverman,Alan P. Farwell,Marjorie Safran,Sharon Alex,S Dubord,Jack L. Leonard +6 more
TL;DR: It is demonstrated that the thyroid is the major source of T3 in the rat and suggested that intrathyroidal T4 to T3 conversion may account for most of the T3 released by the thyroid.
Journal ArticleDOI
Selenium deficiency and type II 5'-deiodinase regulation in the euthyroid and hypothyroid rat: evidence of a direct effect of thyroxine
Jean-Pierre Chanoine,Marjorie Safran,A P Farwell,P Tranter,D M Ekenbarger,S Dubord,Sharon Alex,J R Arthur,G J Beckett,L. E. Braverman +9 more
TL;DR: The decrease in brain and pituitary 5'D-II activity in selenium-deficient euthyroid rats is due to the T4-dependent increase in the turnover of the enzyme polypeptide, consistent with the finding that 5' D-II is not a seleno-enzyme.
Journal ArticleDOI
Effects of selenium deficiency on thyroid hormone economy in rats.
Jean-Pierre Chanoine,Marjorie Safran,A P Farwell,S Dubord,Sharon Alex,Scott Stone,J R Arthur,L. E. Braverman,Jack L. Leonard +8 more
TL;DR: It is suggested that increased T3 sulfate generation in selenium-deficient rats may lead to greater T3 availability through enterohepatic recycling of the iodothyronine and may explain why there are only minor changes in serum T3 concentrations in seLenium- deficient rats.