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Aaron J. Peoples
Researcher at NovoBiotic Pharmaceuticals
Publications - 23
Citations - 2467
Aaron J. Peoples is an academic researcher from NovoBiotic Pharmaceuticals. The author has contributed to research in topics: Lipid II & Antibiotics. The author has an hindex of 8, co-authored 20 publications receiving 2065 citations.
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Patent
Novel macrolactam compounds
TL;DR: In this article, the authors discuss the development of macrolactams and their analogs, processes for the preparation of these novel macroglactams, and pharmaceutical compositions comprising of the novel macro-actams; and methods of using the macroactams to treat or inhibit various disorders.
Patent
Depsipeptide and uses thereof
Aaron J. Peoples,Dallas Hughes,Losee Lucy Ling,William Millett,Anthony Nitti,Amy Spoering,Victoria Alexandra Steadman,Jean-Yves Christophe Chiva,Linos Lazarides,Michael Kenyon Jones,Karine G. Poullennec,Kim Lewis,Slava S. Epstein +12 more
TL;DR: In this paper, the present invention relates generally to novel depsipeptides, to methods for the preparation of these novel dePSipeptide, to pharmaceutical compositions comprising the novel depseptides; and to methods of using the depseptic drugs to treat or inhibit various disorders.
Journal ArticleDOI
Neocitreamicins I and II, Novel Antibiotics with Activity Against Methicillin‐Resistant Staphylococcus aureus and Vancomycin‐Resistant Enterococci.
Aaron J. Peoples,Qibo Zhang,William Millett,Mithra T. Rothfeder,Brian C. Pescatore,Anne A. Madden,Losee L Ling,Charles Moore +7 more
TL;DR: In this paper, two novel antibiotics, neocitreamicins I and II, were isolated from a fermentation broth of a Nocardia strain using an in situ diffusion chamber that facilitates the cultivation of soil microorganisms.
Patent
Nouveau depsipeptide et ses utilisations
Aaron J. Peoples,Dallas Hughes,Losee Lucy Ling,William Millett,Anthony Nitti,Amy Spoering,Victoria Alexandra Steadman,Jean-Yves Christophe Chiva,Linos Lazarides,Michael Kenyon Jones,Karine Gaelle Poullenec,Kim Lewis +11 more
TL;DR: In this article, the presente invention concerne en general de nouveaux depsipeptides, des procedes de preparation of ces new depsipes, des compositions pharmaceutiques comprenant les new depseptides ; and des procedures d'utilisation des new depeptides for traiter ou inhiber divers troubles.
Posted ContentDOI
A new antibiotic from an uncultured bacterium binds to an immutable target
Rhythm Shukla,Aaron J. Peoples,Kevin C. Ludwig,Sourav Maity,Maik Derks,Stefania De Benedetti,Bram J. A. Vermeulen,F. Lavore,Rodrigo V. Honorato,Fabian Grein,Alexandre M. J. J. Bonvin,Ulrich Kubitscheck,Eefjan Breukink,Catherine Achorn,Anthony Nitti,Christopher J. Schwalen,Amy Spoering,Losee Lucy Ling,Dallas Hughes,Moreno Lelli,Wouter H. Roos,Kim Lewis,O. Schneider,Markus Weingarth +23 more
TL;DR: Clovibactin this paper blocks cell wall synthesis by targeting pyrophosphate of multiple essential peptidoglycan precursors (C55PP, Lipid II and LipidWTA).