Losee Lucy Ling

TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.

TL;DR: It is shown that a range of microorganisms, including environmental species, Escherichia coli, and Mycobacterium smegmatis, indeed wake up in a seemingly stochastic manner and independently of environmental conditions, even in the longest incubations conducted, and genuine slow growth appears to be less significant than previously believed.

TL;DR: While long-term incubation does not appear to increase the probability of discovering novel species, the technology enabling such incubations, i.e., single-cell cultivation, may still be the method of choice because it minimizes the overall isolation effort and supplies needed.

TL;DR: The mechanism of Teixobactin at the atomic level using a combination of solid-state NMR, microscopy, in vivo assays and molecular dynamics simulations was revealed in this paper .

TL;DR: This work screens extracts from previously uncultured soil microbes for specific activity against Mycobacterium tuberculosis, identifying three novel compounds and defines the mechanism of action of one compound, amycobactin, and demonstrates that it inhibits protein secretion through the Sec translocation machinery.