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Bram J. A. Vermeulen
Researcher at Utrecht University
Publications - 10
Citations - 119
Bram J. A. Vermeulen is an academic researcher from Utrecht University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 2, co-authored 3 publications receiving 32 citations.
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Journal ArticleDOI
Mode of action of teixobactins in cellular membranes
Rhythm Shukla,João Medeiros-Silva,Anish Parmar,Anish Parmar,Bram J. A. Vermeulen,Sanjit Das,Sanjit Das,Alessandra Lucini Paioni,Shehrazade Jekhmane,Joseph H. Lorent,Alexandre M. J. J. Bonvin,Marc Baldus,Moreno Lelli,Edwin J.A. Veldhuizen,Eefjan Breukink,Ishwar Singh,Ishwar Singh,Markus Weingarth +17 more
TL;DR: Solid-state NMR is used to reveal the native binding mode of teixobactins and show that teixOBactins only weakly bind to Lipid II in anionic cellular membranes, implying the direct interaction with cell wall precursors is not the sole killing mechanism.
Journal ArticleDOI
Teixobactin kills bacteria by a two-pronged attack on the cell envelope
Rhythm Shukla,F. Lavore,Sourav Maity,Maik Derks,Chelsea R Jones,Bram J. A. Vermeulen,Adéla Melcrová,Michael A. Morris,Lea Marie Becker,Xiaoqi Wang,Raj Aditya Kumar,João Medeiros-Silva,Roy A M van Beekveld,Alexandre M. J. J. Bonvin,Joseph H. Lorent,Moreno Lelli,James S. Nowick,Harold D. MacGillavry,Aaron J. Peoples,Amy Spoering,Losee Lucy Ling,Dallas Hughes,Wouter H. Roos,Eefjan Breukink,Kim Lewis,Markus Weingarth +25 more
TL;DR: The mechanism of Teixobactin at the atomic level using a combination of solid-state NMR, microscopy, in vivo assays and molecular dynamics simulations was revealed in this paper .
Journal ArticleDOI
Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase.
Leander Goldbach,Bram J. A. Vermeulen,Sami Caner,Minglong Liu,Christina Tysoe,Lieke van Gijzel,Ryoji Yoshisada,Mikael Trellet,Hugo van Ingen,Gary D. Brayer,Alexandre M. J. J. Bonvin,Seino A. K. Jongkees +11 more
TL;DR: The results suggest that intramolecular hydrophobic interactions are important for priming binding of small macrocyclic peptides to their target and that high rigidity is not necessary for high affinity.
Journal ArticleDOI
Modular assembly of the principal microtubule nucleator γ-TuRC
Martin Würtz,Erik Zupa,Enrico Atorino,Annett Neuner,Anna Böhler,Ariani S. Rahadian,Bram J. A. Vermeulen,Giulia Tonon,Sebastian Eustermann,Elmar Schiebel,Stefan Pfeffer +10 more
TL;DR: In this article , the structural mechanism underlying modular γ-TuRC assembly and identify a functional role of actin in microtubule nucleation was revealed, which is required for efficient micro-tubule fusion and mitotic chromosome alignment in vivo.
Journal ArticleDOI
Modular assembly of the principal microtubule nucleator γ-TuRC
Martin Würtz,Erik Zupa,Enrico Atorino,Annett Neuner,Anna Böhler,Ariani S. Rahadian,Bram J. A. Vermeulen,Giulia Tonon,Sebastian Eustermann,Elmar Schiebel,Stefan Pfeffer +10 more
TL;DR: In this article , the structural mechanism underlying modular γ-TuRC assembly and identify a functional role of actin in microtubule nucleation was revealed, and a GCP6-stabilized core was expanded by stepwise recruitment, selective stabilization and conformational locking of four pre-formed GCP2-GCP3 units.