A
Abdhesh Kumar
Researcher at Central Drug Research Institute
Publications - 34
Citations - 1020
Abdhesh Kumar is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Catalysis & One-pot synthesis. The author has an hindex of 15, co-authored 34 publications receiving 911 citations. Previous affiliations of Abdhesh Kumar include Council of Scientific and Industrial Research & University of California, San Diego.
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Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents.
TL;DR: The most promising compound 26 showed around 30-fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC(50) value of 3.59 μM.
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Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents.
Koneni V. Sashidhara,Abdhesh Kumar,Manavi Chatterjee,K. Bhaskara Rao,Seema Singh,Anil Kumar Verma,Gautam Palit +6 more
TL;DR: A series of 3-phenylcoumarins synthesized and screened for potential antidepressant activity by tail suspension test (TST) in mice exhibited impressive antidepressant activity, measured in terms of percentage decrease in immobility duration.
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Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives.
TL;DR: A series of novel coumarin bisindole heterocycles synthesized following an uncommon method showed potent antihyperlipidemic activity and was found to decrease the plasma triglyceride levels, total cholesterol, and HDL-C/TC ratio in hyper Lipidemic rats to a greater degree than some of the reference statins.
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Discovery of coumarin-dihydropyridine hybrids as bone anabolic agents.
Koneni V. Sashidhara,Manoj Kumar,Vikram Khedgikar,Priyanka Kushwaha,Ram K. Modukuri,Abdhesh Kumar,Jyoti Gautam,Divya Singh,Balasubramaniam Sridhar,Ritu Trivedi +9 more
TL;DR: From these studies compound 18 proved to be useful, which at low oral dose of 1 (mg/kg)/day body weight increased bone mass density and volume, expression of osteogenic genes, bone formation rate, and mineral apposition rate, improved the trabecular microarchitecture, and decreased bone turn over markers in an ovariectomized rodent model for postmenopausal osteoporosis.
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Molecular iodine catalysed one-pot synthesis of chromeno[4,3-b]quinolin-6-ones under microwave irradiation
Koneni V. Sashidhara,Gopala Reddy Palnati,L. Ravithej Singh,Amit Upadhyay,Srinivasa Rao Avula,Abdhesh Kumar,Ruchir Kant +6 more
TL;DR: A facile one pot approach for the regioselective synthesis of chromeno[4,3-b]quinolin-6-one derivatives in excellent yields under microwave (MW) irradiation is demonstrated.