P
Priyanka Kushwaha
Researcher at Central Drug Research Institute
Publications - 49
Citations - 1275
Priyanka Kushwaha is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Osteoblast & Bone remodeling. The author has an hindex of 19, co-authored 43 publications receiving 936 citations. Previous affiliations of Priyanka Kushwaha include Academy of Scientific and Innovative Research & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes
Soohyun P. Kim,Julie L. Frey,Zhu Li,Priyanka Kushwaha,Meredith L. Zoch,Ryan E. Tomlinson,Hao Da,Susan Aja,Hye Lim Noh,Jason K. Kim,Mehboob A. Hussain,Daniel L.J. Thorek,Michael J. Wolfgang,Ryan C. Riddle,Ryan C. Riddle +14 more
TL;DR: It is demonstrated that in addition to a dramatic increase in bone mass, Sost−/− mice as well as those treated with a sclerostin-neutralizing antibody exhibit a reduction in white adipose tissue mass and are protected from high fat diet feeding.
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Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone.
Vikram Khedgikar,Priyanka Kushwaha,Jyoti Gautam,Ashwni Verma,Bendangla Changkija,Ambrish Kumar,Shweta Sharma,Geet Kumar Nagar,Divya Singh,Prabodh Kumar Trivedi,Neelam S. Sangwan,Prabhat Ranjan Mishra,Ritu Trivedi +12 more
TL;DR: It is suggested that WFA stimulates bone formation by abrogating proteasomal machinery and provides knowledge base for its clinical evaluation as a bone anabolic agent.
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Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner
Soohyun P. Kim,Zhu Li,Meredith L. Zoch,Julie L. Frey,Caitlyn E. Bowman,Priyanka Kushwaha,Kathleen A. Ryan,Brian C. Goh,Susanna Scafidi,Julie E. Pickett,Marie-Claude Faugere,Erin E. Kershaw,Daniel L.J. Thorek,Thomas L. Clemens,Michael J. Wolfgang,Ryan C. Riddle +15 more
TL;DR: Examining fatty acid uptake by bone and disrupting the expression of carnitine palmitoyltransferase 2 in osteoblasts and osteocytes demonstrate a requirement for fatty acid oxidation during bone accrual and suggest a role for the skeleton in lipid homeostasis.
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Discovery of coumarin-dihydropyridine hybrids as bone anabolic agents.
Koneni V. Sashidhara,Manoj Kumar,Vikram Khedgikar,Priyanka Kushwaha,Ram K. Modukuri,Abdhesh Kumar,Jyoti Gautam,Divya Singh,Balasubramaniam Sridhar,Ritu Trivedi +9 more
TL;DR: From these studies compound 18 proved to be useful, which at low oral dose of 1 (mg/kg)/day body weight increased bone mass density and volume, expression of osteogenic genes, bone formation rate, and mineral apposition rate, improved the trabecular microarchitecture, and decreased bone turn over markers in an ovariectomized rodent model for postmenopausal osteoporosis.
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A novel therapeutic approach with Caviunin-based isoflavonoid that en routes bone marrow cells to bone formation via BMP2/Wnt-β-catenin signaling.
Priyanka Kushwaha,Vikram Khedgikar,Jyoti Gautam,Preety Dixit,Raju Chillara,Ashwni Verma,Ravi Thakur,Durga Prasad Mishra,Divya Singh,Ranjani Maurya,Naibedya Chattopadhyay,Prabhat Ranjan Mishra,Ritu Trivedi +12 more
TL;DR: The osteogenic potential of CAFG is shown as an alternative for anabolic therapy for the treatment of osteoporosis by stimulating bone morphogenetic protein 2 (BMP2) and Wnt/β-catenin mechanism and could be positioned as a potential drug, food supplement, for postmenopausal osteopOrosis and fracture repair.