V
Vikram Khedgikar
Researcher at Central Drug Research Institute
Publications - 37
Citations - 992
Vikram Khedgikar is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Osteoblast & Bone remodeling. The author has an hindex of 18, co-authored 37 publications receiving 798 citations. Previous affiliations of Vikram Khedgikar include Council of Scientific and Industrial Research & Jawaharlal Nehru University.
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Journal ArticleDOI
Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone.
Vikram Khedgikar,Priyanka Kushwaha,Jyoti Gautam,Ashwni Verma,Bendangla Changkija,Ambrish Kumar,Shweta Sharma,Geet Kumar Nagar,Divya Singh,Prabodh Kumar Trivedi,Neelam S. Sangwan,Prabhat Ranjan Mishra,Ritu Trivedi +12 more
TL;DR: It is suggested that WFA stimulates bone formation by abrogating proteasomal machinery and provides knowledge base for its clinical evaluation as a bone anabolic agent.
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Discovery of coumarin-dihydropyridine hybrids as bone anabolic agents.
Koneni V. Sashidhara,Manoj Kumar,Vikram Khedgikar,Priyanka Kushwaha,Ram K. Modukuri,Abdhesh Kumar,Jyoti Gautam,Divya Singh,Balasubramaniam Sridhar,Ritu Trivedi +9 more
TL;DR: From these studies compound 18 proved to be useful, which at low oral dose of 1 (mg/kg)/day body weight increased bone mass density and volume, expression of osteogenic genes, bone formation rate, and mineral apposition rate, improved the trabecular microarchitecture, and decreased bone turn over markers in an ovariectomized rodent model for postmenopausal osteoporosis.
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A novel therapeutic approach with Caviunin-based isoflavonoid that en routes bone marrow cells to bone formation via BMP2/Wnt-β-catenin signaling.
Priyanka Kushwaha,Vikram Khedgikar,Jyoti Gautam,Preety Dixit,Raju Chillara,Ashwni Verma,Ravi Thakur,Durga Prasad Mishra,Divya Singh,Ranjani Maurya,Naibedya Chattopadhyay,Prabhat Ranjan Mishra,Ritu Trivedi +12 more
TL;DR: The osteogenic potential of CAFG is shown as an alternative for anabolic therapy for the treatment of osteoporosis by stimulating bone morphogenetic protein 2 (BMP2) and Wnt/β-catenin mechanism and could be positioned as a potential drug, food supplement, for postmenopausal osteopOrosis and fracture repair.
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Constituents of Dalbergia sissoo Roxb. leaves with osteogenic activity.
Preety Dixit,Raju Chillara,Vikram Khedgikar,Jyoti Gautam,Priyanka Kushwaha,Avinash Kumar,Divya Singh,Ritu Trivedi,Rakesh Maurya +8 more
TL;DR: One new isoflavone glucoside, caviunin 7-O-[β-d-apiofuranosyl-(1→6)-β- d-glucopyranoside] (10) and a new itaconic derivative, (E-4-methoxy-2-(3,4-dihydroxybenzylidene)-4-oxobutanoic acid (15) along with series of is oflavones and flav
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Micro-architectural changes in cancellous bone differ in female and male C57BL/6 mice with high-fat diet-induced low bone mineral density.
Jyoti Gautam,Dharmendra Choudhary,Vikram Khedgikar,Priyanka Kushwaha,Ravi Shankar Singh,Divya Singh,Swasti Tiwari,Ritu Trivedi +7 more
TL;DR: Overall, the present data indicate that obesity induced by a HFD aggravates bone loss in the cancellous bone compartment, with a greater loss in males than females, although 10 weeks of HFD treatment did not alter cortical bone mass and strength in both males and females.